Prime

Type your tag names separated by a space and hit enter

Relationships between insulin release and taste.

Abstract

Tasting sweet food elicits insulin release prior to increasing plasma glucose levels, known as cephalic phase insulin release (CPIR). The characteristic of CPIR is that plasma insulin secretion occurs before the rise of the plasma glucose level. In this experiment, we examined whether taste stimuli placed on the tongue could induce CPIR. We used female Wistar rats and five basic taste stimuli: sucrose (sweet), sodium chloride (salty), HCl (sour), quinine (bitter) or monosodium glutamate (umami). Rats reliably exhibited CPIR to sucrose. Sodium chloride, HCl, quinine, or monosodium glutamate did not elicit CPIR. The non-nutritive sweetener saccharine elicited CPIR. However, starch, which is nutritive but non-sweet, did not elicit CPIR although rats showed a strong preference for starch which is a source of glucose. In addition, we studied whether CPIR was related to taste receptor cell activity. We carried out the experiment in rats with bilaterally cut chorda tympani nerves, one of the gustatory nerves. After sectioning, CPIR was not observed for sweet stimulation. From these results, we conclude that sweetness information conducted by thistaste nerve provides essential information for eliciting CPIR.

Links

  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Oral Physiology, School of Dentistry, Meikai University, Saitama 350-0283, Japan. tonosaki@dent.meikai.ac.jp

    , ,

    Source

    Biomedical research (Tokyo, Japan) 28:2 2007 Apr pg 79-83

    MeSH

    Animals
    Blood Glucose
    Electrophysiology
    Glucose
    Insulin
    Male
    Myocardium
    Neurons
    Rats
    Rats, Wistar
    Saccharin
    Sucrose
    Taste
    Taste Buds
    Taste Threshold

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    17510492

    Citation

    TY - JOUR T1 - Relationships between insulin release and taste. AU - Tonosaki,Kazuyuki, AU - Hori,Yasunori, AU - Shimizu,Yasutake, AU - Tonosaki,Keiichi, PY - 2007/5/19/pubmed PY - 2007/7/19/medline PY - 2007/5/19/entrez SP - 79 EP - 83 JF - Biomedical research (Tokyo, Japan) JO - Biomed. Res. VL - 28 IS - 2 N2 - Tasting sweet food elicits insulin release prior to increasing plasma glucose levels, known as cephalic phase insulin release (CPIR). The characteristic of CPIR is that plasma insulin secretion occurs before the rise of the plasma glucose level. In this experiment, we examined whether taste stimuli placed on the tongue could induce CPIR. We used female Wistar rats and five basic taste stimuli: sucrose (sweet), sodium chloride (salty), HCl (sour), quinine (bitter) or monosodium glutamate (umami). Rats reliably exhibited CPIR to sucrose. Sodium chloride, HCl, quinine, or monosodium glutamate did not elicit CPIR. The non-nutritive sweetener saccharine elicited CPIR. However, starch, which is nutritive but non-sweet, did not elicit CPIR although rats showed a strong preference for starch which is a source of glucose. In addition, we studied whether CPIR was related to taste receptor cell activity. We carried out the experiment in rats with bilaterally cut chorda tympani nerves, one of the gustatory nerves. After sectioning, CPIR was not observed for sweet stimulation. From these results, we conclude that sweetness information conducted by thistaste nerve provides essential information for eliciting CPIR. SN - 0388-6107 UR - https://www.unboundmedicine.com/medline/citation/17510492/Relationships_between_insulin_release_and_taste_ L2 - http://japanlinkcenter.org/JST.JSTAGE/biomedres/28.79?from=PubMed ER -