Tags

Type your tag names separated by a space and hit enter

Association between estrogen receptor alpha (ESR1) gene polymorphisms and severe preeclampsia.
Hypertens Res. 2007 Mar; 30(3):205-11.HR

Abstract

Associations have been reported between estrogen receptor alpha (ESR1) gene polymorphisms and various pathological conditions, including cardiovascular diseases. Our aim was to investigate whether two polymorphisms of the ESR1 gene (ESR1 c.454 -397T>C: PvuII restriction site and c.454 -351A>G: XbaI restriction site) are associated with preeclampsia. In a case-control study, we analyzed blood samples from 119 severely preeclamptic patients and 103 normotensive, healthy pregnant women using the polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) method. All of the women were Caucasian. There was no association between severe preeclampsia and the PvuII and XbaI ESR1 gene polymorphisms separately. However, with the simultaneous carriage of both polymorphisms, the TT/AA genotype combination was significantly more frequent in severely preeclamptic patients than in healthy control subjects (24.4% vs. 9.7%, p=0.003), whereas the TT/AG combination was significantly less frequent in the severely preeclamptic group than in the control group (5.0% vs. 18.4%, p=0.002). According to the haplotype estimation, the homozygous T-A haplotype carriers had an increased risk of severe preeclampsia independent of maternal age, prepregnancy BMI, primiparity and smoking status (adjusted odds ratio [OR]: 4.36, 95% confidence interval [CI]: 1.65-11.53). The GG genotype of the XbaI polymorphism was associated with a lower risk of fetal growth restriction in patients with severe preeclampsia (OR: 0.23, 95% CI: 0.07-0.73). In conclusion, the homozygous T-A haplotype carriers of ESR1 PvuII and XbaI polymorphisms showed an increased risk of severe preeclampsia. In addition, the GG genotype of the XbaI polymorphism decreased the risk of fetal growth restriction in severely preeclamptic patients.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Kútvölgyi Clinical Center, Semmelweis University, Budapest, Hungary. molvarec@freemail.huNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17510501

Citation

Molvarec, Attila, et al. "Association Between Estrogen Receptor Alpha (ESR1) Gene Polymorphisms and Severe Preeclampsia." Hypertension Research : Official Journal of the Japanese Society of Hypertension, vol. 30, no. 3, 2007, pp. 205-11.
Molvarec A, Vér A, Fekete A, et al. Association between estrogen receptor alpha (ESR1) gene polymorphisms and severe preeclampsia. Hypertens Res. 2007;30(3):205-11.
Molvarec, A., Vér, A., Fekete, A., Rosta, K., Derzbach, L., Derzsy, Z., Karádi, I., & Rigó, J. (2007). Association between estrogen receptor alpha (ESR1) gene polymorphisms and severe preeclampsia. Hypertension Research : Official Journal of the Japanese Society of Hypertension, 30(3), 205-11.
Molvarec A, et al. Association Between Estrogen Receptor Alpha (ESR1) Gene Polymorphisms and Severe Preeclampsia. Hypertens Res. 2007;30(3):205-11. PubMed PMID: 17510501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between estrogen receptor alpha (ESR1) gene polymorphisms and severe preeclampsia. AU - Molvarec,Attila, AU - Vér,Agota, AU - Fekete,Andrea, AU - Rosta,Klára, AU - Derzbach,László, AU - Derzsy,Zoltán, AU - Karádi,István, AU - Rigó,János,Jr PY - 2007/5/19/pubmed PY - 2007/7/26/medline PY - 2007/5/19/entrez SP - 205 EP - 11 JF - Hypertension research : official journal of the Japanese Society of Hypertension JO - Hypertens Res VL - 30 IS - 3 N2 - Associations have been reported between estrogen receptor alpha (ESR1) gene polymorphisms and various pathological conditions, including cardiovascular diseases. Our aim was to investigate whether two polymorphisms of the ESR1 gene (ESR1 c.454 -397T>C: PvuII restriction site and c.454 -351A>G: XbaI restriction site) are associated with preeclampsia. In a case-control study, we analyzed blood samples from 119 severely preeclamptic patients and 103 normotensive, healthy pregnant women using the polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) method. All of the women were Caucasian. There was no association between severe preeclampsia and the PvuII and XbaI ESR1 gene polymorphisms separately. However, with the simultaneous carriage of both polymorphisms, the TT/AA genotype combination was significantly more frequent in severely preeclamptic patients than in healthy control subjects (24.4% vs. 9.7%, p=0.003), whereas the TT/AG combination was significantly less frequent in the severely preeclamptic group than in the control group (5.0% vs. 18.4%, p=0.002). According to the haplotype estimation, the homozygous T-A haplotype carriers had an increased risk of severe preeclampsia independent of maternal age, prepregnancy BMI, primiparity and smoking status (adjusted odds ratio [OR]: 4.36, 95% confidence interval [CI]: 1.65-11.53). The GG genotype of the XbaI polymorphism was associated with a lower risk of fetal growth restriction in patients with severe preeclampsia (OR: 0.23, 95% CI: 0.07-0.73). In conclusion, the homozygous T-A haplotype carriers of ESR1 PvuII and XbaI polymorphisms showed an increased risk of severe preeclampsia. In addition, the GG genotype of the XbaI polymorphism decreased the risk of fetal growth restriction in severely preeclamptic patients. SN - 0916-9636 UR - https://www.unboundmedicine.com/medline/citation/17510501/Association_between_estrogen_receptor_alpha__ESR1__gene_polymorphisms_and_severe_preeclampsia_ L2 - http://www.diseaseinfosearch.org/result/5920 DB - PRIME DP - Unbound Medicine ER -