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Relationship of abdominal obesity measured by DXA and waist circumference with insulin sensitivity in Hispanic and non-Hispanic white individuals: the San Luis Valley Diabetes Study.
Diabetes Metab Res Rev. 2008 Jan-Feb; 24(1):33-40.DM

Abstract

BACKGROUND

To determine if dual-energy X-ray absorptiometry (DXA) measures of trunk fat, a user-defined abdominal region of interest (ROI) and waist circumference (WC) differ in their association with insulin sensitivity among Hispanics and non-Hispanic whites (NHW) or explain any ethnic differences in insulin sensitivity.

METHODS

A cross-sectional study of data collected (1997-98) as part of the longitudinal San Luis Valley Diabetes Study was utilized. There were 664 non-diabetic participants including 349 women (220 NHW, 139 Hispanic) and 305 men (197 NHW, 108 Hispanic), average age 63 years. Measurements included body mass index, WC and DXA measures of total and abdominal fat. Fasting glucose and insulin were used to estimate insulin sensitivity using the QUICKI index. A 2-h oral glucose tolerance test was used to classify participants with normal glucose tolerance (NGT) or impaired glucose tolerance (IGT).

RESULTS

Among women with NGT, Hispanics had lower insulin sensitivity, with DXA trunk fat explaining the most variance in QUICKI and 54% of the ethnic difference in QUICKI after adjusting for total body fat and lean mass. Among men with NGT, there were no differences between Hispanics and NHW in insulin sensitivity or any differences in the association of the abdominal fat measures with insulin sensitivity. Among men and women with IGT, the fat distribution variables explained little variance in QUICKI.

CONCLUSIONS

DXA measures of trunk fat provide additional information over WC and the DXA abdominal ROI measure about ethnic differences in insulin sensitivity between older Hispanic and NHW women with NGT.

Authors+Show Affiliations

Department of Health and Exercise Science, Colorado State University, CO 80523, USA. tnelson@cahs.colostate.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17510915

Citation

Nelson, Tracy L., et al. "Relationship of Abdominal Obesity Measured By DXA and Waist Circumference With Insulin Sensitivity in Hispanic and non-Hispanic White Individuals: the San Luis Valley Diabetes Study." Diabetes/metabolism Research and Reviews, vol. 24, no. 1, 2008, pp. 33-40.
Nelson TL, Bessesen DH, Marshall JA. Relationship of abdominal obesity measured by DXA and waist circumference with insulin sensitivity in Hispanic and non-Hispanic white individuals: the San Luis Valley Diabetes Study. Diabetes Metab Res Rev. 2008;24(1):33-40.
Nelson, T. L., Bessesen, D. H., & Marshall, J. A. (2008). Relationship of abdominal obesity measured by DXA and waist circumference with insulin sensitivity in Hispanic and non-Hispanic white individuals: the San Luis Valley Diabetes Study. Diabetes/metabolism Research and Reviews, 24(1), 33-40.
Nelson TL, Bessesen DH, Marshall JA. Relationship of Abdominal Obesity Measured By DXA and Waist Circumference With Insulin Sensitivity in Hispanic and non-Hispanic White Individuals: the San Luis Valley Diabetes Study. Diabetes Metab Res Rev. 2008 Jan-Feb;24(1):33-40. PubMed PMID: 17510915.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of abdominal obesity measured by DXA and waist circumference with insulin sensitivity in Hispanic and non-Hispanic white individuals: the San Luis Valley Diabetes Study. AU - Nelson,Tracy L, AU - Bessesen,Daniel H, AU - Marshall,Julie A, PY - 2007/5/19/pubmed PY - 2008/3/28/medline PY - 2007/5/19/entrez SP - 33 EP - 40 JF - Diabetes/metabolism research and reviews JO - Diabetes Metab Res Rev VL - 24 IS - 1 N2 - BACKGROUND: To determine if dual-energy X-ray absorptiometry (DXA) measures of trunk fat, a user-defined abdominal region of interest (ROI) and waist circumference (WC) differ in their association with insulin sensitivity among Hispanics and non-Hispanic whites (NHW) or explain any ethnic differences in insulin sensitivity. METHODS: A cross-sectional study of data collected (1997-98) as part of the longitudinal San Luis Valley Diabetes Study was utilized. There were 664 non-diabetic participants including 349 women (220 NHW, 139 Hispanic) and 305 men (197 NHW, 108 Hispanic), average age 63 years. Measurements included body mass index, WC and DXA measures of total and abdominal fat. Fasting glucose and insulin were used to estimate insulin sensitivity using the QUICKI index. A 2-h oral glucose tolerance test was used to classify participants with normal glucose tolerance (NGT) or impaired glucose tolerance (IGT). RESULTS: Among women with NGT, Hispanics had lower insulin sensitivity, with DXA trunk fat explaining the most variance in QUICKI and 54% of the ethnic difference in QUICKI after adjusting for total body fat and lean mass. Among men with NGT, there were no differences between Hispanics and NHW in insulin sensitivity or any differences in the association of the abdominal fat measures with insulin sensitivity. Among men and women with IGT, the fat distribution variables explained little variance in QUICKI. CONCLUSIONS: DXA measures of trunk fat provide additional information over WC and the DXA abdominal ROI measure about ethnic differences in insulin sensitivity between older Hispanic and NHW women with NGT. SN - 1520-7552 UR - https://www.unboundmedicine.com/medline/citation/17510915/Relationship_of_abdominal_obesity_measured_by_DXA_and_waist_circumference_with_insulin_sensitivity_in_Hispanic_and_non_Hispanic_white_individuals:_the_San_Luis_Valley_Diabetes_Study_ L2 - https://doi.org/10.1002/dmrr.747 DB - PRIME DP - Unbound Medicine ER -