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Oxidative damage in mild cognitive impairment and early Alzheimer's disease.
J Neurosci Res. 2007 Nov 01; 85(14):3036-40.JN

Abstract

Increasing evidence supports a role for oxidative damage in the pathogenesis of Alzheimer's disease (AD). Multiple studies show significantly increased levels of lipid peroxidation and protein, DNA, and RNA oxidation in vulnerable regions of the brain of patients with late-stage AD (LAD). More recent studies of patients with amnestic mild cognitive impairment (MCI), the earliest clinical manifestation of AD, show similar patterns of oxidative damage. These observations suggest that oxidative damage to critical biomolecules occurs early in the pathogenesis of AD and precedes pronounced neuropathologic alterations. Because oxidative damage begins early in the progress of the disease, it represents a potential therapeutic target for slowing the onset and progression of AD.

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Authors+Show Affiliations

Lovell MA
Department of Chemistry, University of Kentucky, Lexington, Kentucky, USA. malove2@uky.edu
Markesbery WR
No affiliation info available

MeSH

Alzheimer DiseaseAnimalsCognition DisordersHumansLipid PeroxidationOxidation-ReductionOxidative Stress

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17510979

Citation

Lovell, Mark A., and William R. Markesbery. "Oxidative Damage in Mild Cognitive Impairment and Early Alzheimer's Disease." Journal of Neuroscience Research, vol. 85, no. 14, 2007, pp. 3036-40.
Lovell MA, Markesbery WR. Oxidative damage in mild cognitive impairment and early Alzheimer's disease. J Neurosci Res. 2007;85(14):3036-40.
Lovell, M. A., & Markesbery, W. R. (2007). Oxidative damage in mild cognitive impairment and early Alzheimer's disease. Journal of Neuroscience Research, 85(14), 3036-40.
Lovell MA, Markesbery WR. Oxidative Damage in Mild Cognitive Impairment and Early Alzheimer's Disease. J Neurosci Res. 2007 Nov 1;85(14):3036-40. PubMed PMID: 17510979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative damage in mild cognitive impairment and early Alzheimer's disease. AU - Lovell,Mark A, AU - Markesbery,William R, PY - 2007/5/19/pubmed PY - 2008/2/15/medline PY - 2007/5/19/entrez SP - 3036 EP - 40 JF - Journal of neuroscience research JO - J Neurosci Res VL - 85 IS - 14 N2 - Increasing evidence supports a role for oxidative damage in the pathogenesis of Alzheimer's disease (AD). Multiple studies show significantly increased levels of lipid peroxidation and protein, DNA, and RNA oxidation in vulnerable regions of the brain of patients with late-stage AD (LAD). More recent studies of patients with amnestic mild cognitive impairment (MCI), the earliest clinical manifestation of AD, show similar patterns of oxidative damage. These observations suggest that oxidative damage to critical biomolecules occurs early in the pathogenesis of AD and precedes pronounced neuropathologic alterations. Because oxidative damage begins early in the progress of the disease, it represents a potential therapeutic target for slowing the onset and progression of AD. SN - 0360-4012 UR - https://www.unboundmedicine.com/medline/citation/17510979/Oxidative_damage_in_mild_cognitive_impairment_and_early_Alzheimer's_disease_ L2 - https://doi.org/10.1002/jnr.21346 DB - PRIME DP - Unbound Medicine ER -