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Oxidative damage in mild cognitive impairment and early Alzheimer's disease.
J Neurosci Res. 2007 Nov 01; 85(14):3036-40.JN

Abstract

Increasing evidence supports a role for oxidative damage in the pathogenesis of Alzheimer's disease (AD). Multiple studies show significantly increased levels of lipid peroxidation and protein, DNA, and RNA oxidation in vulnerable regions of the brain of patients with late-stage AD (LAD). More recent studies of patients with amnestic mild cognitive impairment (MCI), the earliest clinical manifestation of AD, show similar patterns of oxidative damage. These observations suggest that oxidative damage to critical biomolecules occurs early in the pathogenesis of AD and precedes pronounced neuropathologic alterations. Because oxidative damage begins early in the progress of the disease, it represents a potential therapeutic target for slowing the onset and progression of AD.

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    Authors+Show Affiliations

    Lovell MA
    Department of Chemistry, University of Kentucky, Lexington, Kentucky, USA. malove2@uky.edu
    Markesbery WR
    No affiliation info available

    MeSH

    Alzheimer DiseaseAnimalsCognition DisordersHumansLipid PeroxidationOxidation-ReductionOxidative Stress

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    17510979

    Citation

    Lovell, Mark A., and William R. Markesbery. "Oxidative Damage in Mild Cognitive Impairment and Early Alzheimer's Disease." Journal of Neuroscience Research, vol. 85, no. 14, 2007, pp. 3036-40.
    Lovell MA, Markesbery WR. Oxidative damage in mild cognitive impairment and early Alzheimer's disease. J Neurosci Res. 2007;85(14):3036-40.
    Lovell, M. A., & Markesbery, W. R. (2007). Oxidative damage in mild cognitive impairment and early Alzheimer's disease. Journal of Neuroscience Research, 85(14), 3036-40.
    Lovell MA, Markesbery WR. Oxidative Damage in Mild Cognitive Impairment and Early Alzheimer's Disease. J Neurosci Res. 2007 Nov 1;85(14):3036-40. PubMed PMID: 17510979.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Oxidative damage in mild cognitive impairment and early Alzheimer's disease. AU - Lovell,Mark A, AU - Markesbery,William R, PY - 2007/5/19/pubmed PY - 2008/2/15/medline PY - 2007/5/19/entrez SP - 3036 EP - 40 JF - Journal of neuroscience research JO - J. Neurosci. Res. VL - 85 IS - 14 N2 - Increasing evidence supports a role for oxidative damage in the pathogenesis of Alzheimer's disease (AD). Multiple studies show significantly increased levels of lipid peroxidation and protein, DNA, and RNA oxidation in vulnerable regions of the brain of patients with late-stage AD (LAD). More recent studies of patients with amnestic mild cognitive impairment (MCI), the earliest clinical manifestation of AD, show similar patterns of oxidative damage. These observations suggest that oxidative damage to critical biomolecules occurs early in the pathogenesis of AD and precedes pronounced neuropathologic alterations. Because oxidative damage begins early in the progress of the disease, it represents a potential therapeutic target for slowing the onset and progression of AD. SN - 0360-4012 UR - https://www.unboundmedicine.com/medline/citation/17510979/Oxidative_damage_in_mild_cognitive_impairment_and_early_Alzheimer's_disease_ L2 - https://doi.org/10.1002/jnr.21346 DB - PRIME DP - Unbound Medicine ER -