Abstract
Increasing evidence supports a role for oxidative damage in the pathogenesis of Alzheimer's disease (AD). Multiple studies show significantly increased levels of lipid peroxidation and protein, DNA, and RNA oxidation in vulnerable regions of the brain of patients with late-stage AD (LAD). More recent studies of patients with amnestic mild cognitive impairment (MCI), the earliest clinical manifestation of AD, show similar patterns of oxidative damage. These observations suggest that oxidative damage to critical biomolecules occurs early in the pathogenesis of AD and precedes pronounced neuropathologic alterations. Because oxidative damage begins early in the progress of the disease, it represents a potential therapeutic target for slowing the onset and progression of AD.
Pub Type(s)
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
TY - JOUR
T1 - Oxidative damage in mild cognitive impairment and early Alzheimer's disease.
AU - Lovell,Mark A,
AU - Markesbery,William R,
PY - 2007/5/19/pubmed
PY - 2008/2/15/medline
PY - 2007/5/19/entrez
SP - 3036
EP - 40
JF - Journal of neuroscience research
JO - J Neurosci Res
VL - 85
IS - 14
N2 - Increasing evidence supports a role for oxidative damage in the pathogenesis of Alzheimer's disease (AD). Multiple studies show significantly increased levels of lipid peroxidation and protein, DNA, and RNA oxidation in vulnerable regions of the brain of patients with late-stage AD (LAD). More recent studies of patients with amnestic mild cognitive impairment (MCI), the earliest clinical manifestation of AD, show similar patterns of oxidative damage. These observations suggest that oxidative damage to critical biomolecules occurs early in the pathogenesis of AD and precedes pronounced neuropathologic alterations. Because oxidative damage begins early in the progress of the disease, it represents a potential therapeutic target for slowing the onset and progression of AD.
SN - 0360-4012
UR - https://www.unboundmedicine.com/medline/citation/17510979/Oxidative_damage_in_mild_cognitive_impairment_and_early_Alzheimer's_disease_
L2 - https://doi.org/10.1002/jnr.21346
DB - PRIME
DP - Unbound Medicine
ER -