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Anatomic study for in vivo evaluation of a total artificial heart in calves.
ASAIO Trans. 1991 Jul-Sep; 37(3):M219-20.AT

Abstract

A poor fit will negate any physiologic evaluation of an implantable total artificial heart (TAH). Fifteen Holstein calves (weight, 65-111 kg) were used to measure intrathoracic dimensions for TAH design, to find correlations between intrathoracic and external parameters for preoperative animal selection, and to suggest minor modifications for fitting a TAH in calf chests. The following dimensions were found to be critical to avoid compromising venous return: 1) mitral annulus center (MVC)-sternum, 10.4 +/- 1.0 cm; 2) tricuspid annulus center (TVC)-sternum, 9.8 +/- 1.6 cm; 3) MVC-TVC, 5.5 +/- 0.4 cm; 4) MVC-diaphragm, 3.4 +/- 0.8 cm; 5) MVC-left chest wall, 4.5 +/- 0.9 cm; and 6) TVC-right chest wall, 4.5 +/- 1.0 cm. These dimensions had no statistically significant correlation with body weight, but three of them did with the following external parameters: 1) bronchial carina-sternum on chest radiograph, p less than 0.05; 2) dorsoventral dimension at xiphoid, p less than 0.05; and 3) circumference at the caudal end of the scapula, p less than 0.05. Based on these results, the port orientation of the left housing of this electrohydraulic TAH designed for humans was modified for in vivo evaluation in calves. No other pump features required change. These data should prove useful to others involved in TAH development.

Authors+Show Affiliations

Irié H
Department of Biomedical Engineering and Applied Therapeutics, Cleveland Clinic Foundation, Ohio 44195.
Harasaki H
No affiliation info available
Massiello A
No affiliation info available
Chen JF
No affiliation info available
Fukamachi K
No affiliation info available
Kiraly RJ
No affiliation info available
Golding LA
No affiliation info available

MeSH

AnimalsBiometryCattleHeart, ArtificialMaleModels, CardiovascularProsthesis Design

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1751118

Citation

Irié, H, et al. "Anatomic Study for in Vivo Evaluation of a Total Artificial Heart in Calves." ASAIO Transactions, vol. 37, no. 3, 1991, pp. M219-20.
Irié H, Harasaki H, Massiello A, et al. Anatomic study for in vivo evaluation of a total artificial heart in calves. ASAIO Trans. 1991;37(3):M219-20.
Irié, H., Harasaki, H., Massiello, A., Chen, J. F., Fukamachi, K., Kiraly, R. J., & Golding, L. A. (1991). Anatomic study for in vivo evaluation of a total artificial heart in calves. ASAIO Transactions, 37(3), M219-20.
Irié H, et al. Anatomic Study for in Vivo Evaluation of a Total Artificial Heart in Calves. ASAIO Trans. 1991 Jul-Sep;37(3):M219-20. PubMed PMID: 1751118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anatomic study for in vivo evaluation of a total artificial heart in calves. AU - Irié,H, AU - Harasaki,H, AU - Massiello,A, AU - Chen,J F, AU - Fukamachi,K, AU - Kiraly,R J, AU - Golding,L A, PY - 1991/7/1/pubmed PY - 1991/7/1/medline PY - 1991/7/1/entrez SP - M219 EP - 20 JF - ASAIO transactions JO - ASAIO Trans VL - 37 IS - 3 N2 - A poor fit will negate any physiologic evaluation of an implantable total artificial heart (TAH). Fifteen Holstein calves (weight, 65-111 kg) were used to measure intrathoracic dimensions for TAH design, to find correlations between intrathoracic and external parameters for preoperative animal selection, and to suggest minor modifications for fitting a TAH in calf chests. The following dimensions were found to be critical to avoid compromising venous return: 1) mitral annulus center (MVC)-sternum, 10.4 +/- 1.0 cm; 2) tricuspid annulus center (TVC)-sternum, 9.8 +/- 1.6 cm; 3) MVC-TVC, 5.5 +/- 0.4 cm; 4) MVC-diaphragm, 3.4 +/- 0.8 cm; 5) MVC-left chest wall, 4.5 +/- 0.9 cm; and 6) TVC-right chest wall, 4.5 +/- 1.0 cm. These dimensions had no statistically significant correlation with body weight, but three of them did with the following external parameters: 1) bronchial carina-sternum on chest radiograph, p less than 0.05; 2) dorsoventral dimension at xiphoid, p less than 0.05; and 3) circumference at the caudal end of the scapula, p less than 0.05. Based on these results, the port orientation of the left housing of this electrohydraulic TAH designed for humans was modified for in vivo evaluation in calves. No other pump features required change. These data should prove useful to others involved in TAH development. SN - 0889-7190 UR - https://www.unboundmedicine.com/medline/citation/1751118/Anatomic_study_for_in_vivo_evaluation_of_a_total_artificial_heart_in_calves_ DB - PRIME DP - Unbound Medicine ER -