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[Endoscopic examination including magnifying endoscopy for diagnosis of GERD].
Nihon Rinsho. 2007 May; 65(5):865-71.NR

Abstract

Symptoms of heartburn and regurgitation are the most important for diagnosis of gastroesophageal reflux disease (GERD) in the clinical field. Endoscopic examination is also widely used modality for Los Angeles classification of GERD according to endoscopic severity of esophageal mucosal breaks. However, about half of GERD patients reveal no abnormality under conventional endoscopy. These endoscopic negative GERD is called as non-erosive reflux disease (NERD). There is the possibility to underestimate a minute mucosal change of GERD by conventional endoscopy that has the limitation of visual ability. Magnifying endoscopic examination is able to get clear visualization of intrapapillary capillary loops(IPCL), which are usually shown as dot-like structures in esophageal mucosa by a conventional endoscopy. The changing of IPCLs is associated with inflammation and neoplasia of esophagus. Minute change of IPCLs such as a dilation and elongation with regular intervals were reported to be suggestive of inflammatory change in esophagus. Magnifying endoscopic observation of IPCLs is useful for diagnosis of NERD which cannot be visualized by conventional endoscopy.

Authors+Show Affiliations

Division of Endoscopy, Hokkaido University Hospital.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

jpn

PubMed ID

17511225

Citation

Kato, Mototsugu, et al. "[Endoscopic Examination Including Magnifying Endoscopy for Diagnosis of GERD]." Nihon Rinsho. Japanese Journal of Clinical Medicine, vol. 65, no. 5, 2007, pp. 865-71.
Kato M, Ono S, Nakagawa M, et al. [Endoscopic examination including magnifying endoscopy for diagnosis of GERD]. Nippon Rinsho. 2007;65(5):865-71.
Kato, M., Ono, S., Nakagawa, M., Shimizu, Y., & Asaka, M. (2007). [Endoscopic examination including magnifying endoscopy for diagnosis of GERD]. Nihon Rinsho. Japanese Journal of Clinical Medicine, 65(5), 865-71.
Kato M, et al. [Endoscopic Examination Including Magnifying Endoscopy for Diagnosis of GERD]. Nippon Rinsho. 2007;65(5):865-71. PubMed PMID: 17511225.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Endoscopic examination including magnifying endoscopy for diagnosis of GERD]. AU - Kato,Mototsugu, AU - Ono,Shoko, AU - Nakagawa,Manabu, AU - Shimizu,Yuichi, AU - Asaka,Masahiro, PY - 2007/5/22/pubmed PY - 2007/7/20/medline PY - 2007/5/22/entrez SP - 865 EP - 71 JF - Nihon rinsho. Japanese journal of clinical medicine JO - Nippon Rinsho VL - 65 IS - 5 N2 - Symptoms of heartburn and regurgitation are the most important for diagnosis of gastroesophageal reflux disease (GERD) in the clinical field. Endoscopic examination is also widely used modality for Los Angeles classification of GERD according to endoscopic severity of esophageal mucosal breaks. However, about half of GERD patients reveal no abnormality under conventional endoscopy. These endoscopic negative GERD is called as non-erosive reflux disease (NERD). There is the possibility to underestimate a minute mucosal change of GERD by conventional endoscopy that has the limitation of visual ability. Magnifying endoscopic examination is able to get clear visualization of intrapapillary capillary loops(IPCL), which are usually shown as dot-like structures in esophageal mucosa by a conventional endoscopy. The changing of IPCLs is associated with inflammation and neoplasia of esophagus. Minute change of IPCLs such as a dilation and elongation with regular intervals were reported to be suggestive of inflammatory change in esophagus. Magnifying endoscopic observation of IPCLs is useful for diagnosis of NERD which cannot be visualized by conventional endoscopy. SN - 0047-1852 UR - https://www.unboundmedicine.com/medline/citation/17511225/[Endoscopic_examination_including_magnifying_endoscopy_for_diagnosis_of_GERD]_ L2 - https://medlineplus.gov/gerd.html DB - PRIME DP - Unbound Medicine ER -