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Garlic oil ameliorates ferric nitrilotriacetate (Fe-NTA)-induced damage and tumor promotion: implications for cancer prevention.
Food Chem Toxicol. 2007 Sep; 45(9):1634-40.FC

Abstract

Intraperitoneal injection of ferric nitrilotriacetate (Fe-NTA) to rats and mice results in iron-induced free radical injury and cancer in kidneys. This study was designed to investigate the effects of garlic oil on Fe-NTA-induced damage and tumor promotion. Pretreatment of rats with garlic oil at a dose regimen of 50-100 mg/kg body weight for a week significantly and dose dependently protected against Fe-NTA induced damage as well as tumor promotion. Garlic oil afforded protection against hepatic lipid peroxidation, generation of hydrogen peroxide, preserved glutathione levels and activities of antioxidant enzymes. A protection against Fe-NTA induced hepatic tumor promotion was also apparent as inhibition in the modulation of hepatic tumor markers viz., ornithine decarboxylase activity and DNA synthesis. These results clearly demonstrate the role of oxidative stress and its relation to tumor promotion and suggest protective effects of garlic oil against Fe-NTA induced hepatic toxicity and it can serve as potent chemopreventive agent to suppress oxidant-induced tissue injury and carcinogenesis.

Authors+Show Affiliations

Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi-110062, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17512651

Citation

Agarwal, Mukesh Kumar, et al. "Garlic Oil Ameliorates Ferric Nitrilotriacetate (Fe-NTA)-induced Damage and Tumor Promotion: Implications for Cancer Prevention." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 45, no. 9, 2007, pp. 1634-40.
Agarwal MK, Iqbal M, Athar M. Garlic oil ameliorates ferric nitrilotriacetate (Fe-NTA)-induced damage and tumor promotion: implications for cancer prevention. Food Chem Toxicol. 2007;45(9):1634-40.
Agarwal, M. K., Iqbal, M., & Athar, M. (2007). Garlic oil ameliorates ferric nitrilotriacetate (Fe-NTA)-induced damage and tumor promotion: implications for cancer prevention. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 45(9), 1634-40.
Agarwal MK, Iqbal M, Athar M. Garlic Oil Ameliorates Ferric Nitrilotriacetate (Fe-NTA)-induced Damage and Tumor Promotion: Implications for Cancer Prevention. Food Chem Toxicol. 2007;45(9):1634-40. PubMed PMID: 17512651.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Garlic oil ameliorates ferric nitrilotriacetate (Fe-NTA)-induced damage and tumor promotion: implications for cancer prevention. AU - Agarwal,Mukesh Kumar, AU - Iqbal,Mohammad, AU - Athar,Mohammad, Y1 - 2007/02/28/ PY - 2006/04/02/received PY - 2007/01/09/revised PY - 2007/02/23/accepted PY - 2007/5/22/pubmed PY - 2007/10/4/medline PY - 2007/5/22/entrez SP - 1634 EP - 40 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 45 IS - 9 N2 - Intraperitoneal injection of ferric nitrilotriacetate (Fe-NTA) to rats and mice results in iron-induced free radical injury and cancer in kidneys. This study was designed to investigate the effects of garlic oil on Fe-NTA-induced damage and tumor promotion. Pretreatment of rats with garlic oil at a dose regimen of 50-100 mg/kg body weight for a week significantly and dose dependently protected against Fe-NTA induced damage as well as tumor promotion. Garlic oil afforded protection against hepatic lipid peroxidation, generation of hydrogen peroxide, preserved glutathione levels and activities of antioxidant enzymes. A protection against Fe-NTA induced hepatic tumor promotion was also apparent as inhibition in the modulation of hepatic tumor markers viz., ornithine decarboxylase activity and DNA synthesis. These results clearly demonstrate the role of oxidative stress and its relation to tumor promotion and suggest protective effects of garlic oil against Fe-NTA induced hepatic toxicity and it can serve as potent chemopreventive agent to suppress oxidant-induced tissue injury and carcinogenesis. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/17512651/Garlic_oil_ameliorates_ferric_nitrilotriacetate__Fe_NTA__induced_damage_and_tumor_promotion:_implications_for_cancer_prevention_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(07)00086-5 DB - PRIME DP - Unbound Medicine ER -