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Effects of lithium and valproate on serum and hippocampal neurotrophin-3 levels in an animal model of mania.
J Psychiatr Res 2008; 42(5):416-21JP

Abstract

It has been demonstrated that lithium (Li) and valproate (VPT), first line mood stabilizers, increase BDNF content in rat hippocampus and frontal cortex, which suggests that the regulation of neurotrophic factors might be associated with their pharmacological effects. In sight of the scarcity of studies with other neurotrophins, and the possible relevance of multiple neurotrophic signaling systems in bipolar disorder we investigated the effects of Li and VPT on NT-3 levels in rat serum and hippocampus, using an animal model of mania induced by amphetamine (AMPH). In the reversal model, adult male Wistar rats received AMPH or saline for 14 days, and between the 8th and 14th days, animals were treated with Li, VPT or saline. In the prevention model, rats were pretreated with Li, VPT or saline, and between the 8th and 14th days, the animals received AMPH or saline. Li increased serum and hippocampal NT-3 levels in all conditions, whereas VPT increased hippocampal NT-3 in the prevention model only. Li reversed AMPH changes in NT-3 in the reversal model, and VPT prevented AMPH changes in NT-3 in the prevention model. These results suggest that both Li and VPT modulate serum and central (hippocampal) NT-3 levels, and further support that the regulation of neurotrophic signaling systems may be related to the mechanisms of action of mood stabilizers.

Authors+Show Affiliations

Bipolar Disorders Program, Centro de Pesquisas, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos, 2350, 90035-003 Porto Alegre, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17512948

Citation

Walz, Julio C., et al. "Effects of Lithium and Valproate On Serum and Hippocampal Neurotrophin-3 Levels in an Animal Model of Mania." Journal of Psychiatric Research, vol. 42, no. 5, 2008, pp. 416-21.
Walz JC, Frey BN, Andreazza AC, et al. Effects of lithium and valproate on serum and hippocampal neurotrophin-3 levels in an animal model of mania. J Psychiatr Res. 2008;42(5):416-21.
Walz, J. C., Frey, B. N., Andreazza, A. C., Ceresér, K. M., Cacilhas, A. A., Valvassori, S. S., ... Kapczinski, F. (2008). Effects of lithium and valproate on serum and hippocampal neurotrophin-3 levels in an animal model of mania. Journal of Psychiatric Research, 42(5), pp. 416-21.
Walz JC, et al. Effects of Lithium and Valproate On Serum and Hippocampal Neurotrophin-3 Levels in an Animal Model of Mania. J Psychiatr Res. 2008;42(5):416-21. PubMed PMID: 17512948.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of lithium and valproate on serum and hippocampal neurotrophin-3 levels in an animal model of mania. AU - Walz,Julio C, AU - Frey,Benício N, AU - Andreazza,Ana C, AU - Ceresér,Keila M, AU - Cacilhas,Alice A, AU - Valvassori,Samira S, AU - Quevedo,João, AU - Kapczinski,Flávio, Y1 - 2007/05/21/ PY - 2006/12/17/received PY - 2007/03/08/revised PY - 2007/03/29/accepted PY - 2007/5/22/pubmed PY - 2008/6/12/medline PY - 2007/5/22/entrez SP - 416 EP - 21 JF - Journal of psychiatric research JO - J Psychiatr Res VL - 42 IS - 5 N2 - It has been demonstrated that lithium (Li) and valproate (VPT), first line mood stabilizers, increase BDNF content in rat hippocampus and frontal cortex, which suggests that the regulation of neurotrophic factors might be associated with their pharmacological effects. In sight of the scarcity of studies with other neurotrophins, and the possible relevance of multiple neurotrophic signaling systems in bipolar disorder we investigated the effects of Li and VPT on NT-3 levels in rat serum and hippocampus, using an animal model of mania induced by amphetamine (AMPH). In the reversal model, adult male Wistar rats received AMPH or saline for 14 days, and between the 8th and 14th days, animals were treated with Li, VPT or saline. In the prevention model, rats were pretreated with Li, VPT or saline, and between the 8th and 14th days, the animals received AMPH or saline. Li increased serum and hippocampal NT-3 levels in all conditions, whereas VPT increased hippocampal NT-3 in the prevention model only. Li reversed AMPH changes in NT-3 in the reversal model, and VPT prevented AMPH changes in NT-3 in the prevention model. These results suggest that both Li and VPT modulate serum and central (hippocampal) NT-3 levels, and further support that the regulation of neurotrophic signaling systems may be related to the mechanisms of action of mood stabilizers. SN - 0022-3956 UR - https://www.unboundmedicine.com/medline/citation/17512948/Effects_of_lithium_and_valproate_on_serum_and_hippocampal_neurotrophin_3_levels_in_an_animal_model_of_mania_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3956(07)00075-1 DB - PRIME DP - Unbound Medicine ER -