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Predictive factors of meticillin resistance among patients with Staphylococcus aureus bloodstream infections at hospital admission.
J Hosp Infect 2007; 66(2):135-41JH

Abstract

Meticillin-resistant Staphylococcus aureus (MRSA) is prevalent throughout the healthcare system in Spain, particularly in long-term care facilities (LTCF) and the incidence of MRSA bloodstream infection (MRSA-BSI) at hospital admission is increasing. This study aimed to determine factors that predict meticillin resistance among patients who require hospitalization for S. aureus BSI. We performed a case-control study comparing patients with S. aureus at hospital admission from January 1991 to December 2003. Case patients with MRSA-BSI at hospital admission (N=50) were compared with control patients with meticillin-susceptible S. aureus bloodstream infection (MSSA-BSI) at hospital admission (N=98). The incidence of MRSA-BSI at hospital admission increased significantly from 0.08 cases/1000 hospital admissions in 1991 to 0.37 cases in 2003 (P<0.001). Univariate analysis comparing patients with MRSA- and MSSA-BSI found a significant association between meticillin resistance and age >60 years, female sex, prior MRSA isolation and healthcare-related BSI. No differences were found in underlying conditions such as diabetes, haemodialysis, immunosuppression, source of infection or mortality between the two groups. Multivariate analyses identified prior MRSA isolation [odds ratio (OR): 41; 95% confidence interval (CI): 4-350] and admission from long-term care facilities (OR: 37; 95% CI: 4.5-316) as independent risk factors for MRSA-BSI.

Authors+Show Affiliations

Infectious Diseases Service, Hospital Universitari de Bellvitge, Feixa Llarga s/n, L'Hospitalet de Llobregat, Barcelona 08907, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17513007

Citation

Manzur, A, et al. "Predictive Factors of Meticillin Resistance Among Patients With Staphylococcus Aureus Bloodstream Infections at Hospital Admission." The Journal of Hospital Infection, vol. 66, no. 2, 2007, pp. 135-41.
Manzur A, Vidal M, Pujol M, et al. Predictive factors of meticillin resistance among patients with Staphylococcus aureus bloodstream infections at hospital admission. J Hosp Infect. 2007;66(2):135-41.
Manzur, A., Vidal, M., Pujol, M., Cisnal, M., Hornero, A., Masuet, C., ... Ariza, J. (2007). Predictive factors of meticillin resistance among patients with Staphylococcus aureus bloodstream infections at hospital admission. The Journal of Hospital Infection, 66(2), pp. 135-41.
Manzur A, et al. Predictive Factors of Meticillin Resistance Among Patients With Staphylococcus Aureus Bloodstream Infections at Hospital Admission. J Hosp Infect. 2007;66(2):135-41. PubMed PMID: 17513007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictive factors of meticillin resistance among patients with Staphylococcus aureus bloodstream infections at hospital admission. AU - Manzur,A, AU - Vidal,M, AU - Pujol,M, AU - Cisnal,M, AU - Hornero,A, AU - Masuet,C, AU - Peña,C, AU - Gudiol,F, AU - Ariza,J, Y1 - 2007/05/21/ PY - 2006/08/14/received PY - 2007/03/20/accepted PY - 2007/5/22/pubmed PY - 2007/8/19/medline PY - 2007/5/22/entrez SP - 135 EP - 41 JF - The Journal of hospital infection JO - J. Hosp. Infect. VL - 66 IS - 2 N2 - Meticillin-resistant Staphylococcus aureus (MRSA) is prevalent throughout the healthcare system in Spain, particularly in long-term care facilities (LTCF) and the incidence of MRSA bloodstream infection (MRSA-BSI) at hospital admission is increasing. This study aimed to determine factors that predict meticillin resistance among patients who require hospitalization for S. aureus BSI. We performed a case-control study comparing patients with S. aureus at hospital admission from January 1991 to December 2003. Case patients with MRSA-BSI at hospital admission (N=50) were compared with control patients with meticillin-susceptible S. aureus bloodstream infection (MSSA-BSI) at hospital admission (N=98). The incidence of MRSA-BSI at hospital admission increased significantly from 0.08 cases/1000 hospital admissions in 1991 to 0.37 cases in 2003 (P<0.001). Univariate analysis comparing patients with MRSA- and MSSA-BSI found a significant association between meticillin resistance and age >60 years, female sex, prior MRSA isolation and healthcare-related BSI. No differences were found in underlying conditions such as diabetes, haemodialysis, immunosuppression, source of infection or mortality between the two groups. Multivariate analyses identified prior MRSA isolation [odds ratio (OR): 41; 95% confidence interval (CI): 4-350] and admission from long-term care facilities (OR: 37; 95% CI: 4.5-316) as independent risk factors for MRSA-BSI. SN - 0195-6701 UR - https://www.unboundmedicine.com/medline/citation/17513007/Predictive_factors_of_meticillin_resistance_among_patients_with_Staphylococcus_aureus_bloodstream_infections_at_hospital_admission_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0195-6701(07)00099-0 DB - PRIME DP - Unbound Medicine ER -