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Non-hypertrophic familial neuropathy associated with intention tremor. A variety of Charcot-Marie-Tooth disease?
J Neurol Sci. 1976 Jan; 27(1):59-69.JN

Abstract

A family with an association of sensorimotor neuropathy and intention tremor is reported. Clinical examination of 3 affected family members showed in varying degrees areflexia, muscle wasting, impairment of deep sensation with an ataxic gait, pes cavus and disabling intention tremor. Motor nerve conduction velocities were moderately slowed. A superficial peroneal nerve biopsy showed axonal degeneration without segmental demyelination or onion bulb formation. Our observation seems to indicate an association of intention tremor with the non-hypertrophic variety of Charcot-Marie-Tooth disease. It can therefore be suggested that the two classical types of Charcot-Marie-Tooth syndrome possess variants which are associated with intention tremor. This association is well-known for the hypertrophic type; our report gives an example of the non-hypertrophic type.

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Publisher Full Text

Authors

Delwaide PJ
No affiliation info available
Schoenen J
No affiliation info available

MeSH

AdultAgedCharcot-Marie-Tooth DiseaseFemaleHumansMaleMiddle AgedMovementMusclesMuscular AtrophyNeural ConductionPeripheral Nervous System DiseasesPeroneal NerveTremor

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

175133

Citation

Delwaide, P J., and J Schoenen. "Non-hypertrophic Familial Neuropathy Associated With Intention Tremor. a Variety of Charcot-Marie-Tooth Disease?" Journal of the Neurological Sciences, vol. 27, no. 1, 1976, pp. 59-69.
Delwaide PJ, Schoenen J. Non-hypertrophic familial neuropathy associated with intention tremor. A variety of Charcot-Marie-Tooth disease? J Neurol Sci. 1976;27(1):59-69.
Delwaide, P. J., & Schoenen, J. (1976). Non-hypertrophic familial neuropathy associated with intention tremor. A variety of Charcot-Marie-Tooth disease? Journal of the Neurological Sciences, 27(1), 59-69.
Delwaide PJ, Schoenen J. Non-hypertrophic Familial Neuropathy Associated With Intention Tremor. a Variety of Charcot-Marie-Tooth Disease. J Neurol Sci. 1976;27(1):59-69. PubMed PMID: 175133.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-hypertrophic familial neuropathy associated with intention tremor. A variety of Charcot-Marie-Tooth disease? AU - Delwaide,P J, AU - Schoenen,J, PY - 1976/1/1/pubmed PY - 1976/1/1/medline PY - 1976/1/1/entrez SP - 59 EP - 69 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 27 IS - 1 N2 - A family with an association of sensorimotor neuropathy and intention tremor is reported. Clinical examination of 3 affected family members showed in varying degrees areflexia, muscle wasting, impairment of deep sensation with an ataxic gait, pes cavus and disabling intention tremor. Motor nerve conduction velocities were moderately slowed. A superficial peroneal nerve biopsy showed axonal degeneration without segmental demyelination or onion bulb formation. Our observation seems to indicate an association of intention tremor with the non-hypertrophic variety of Charcot-Marie-Tooth disease. It can therefore be suggested that the two classical types of Charcot-Marie-Tooth syndrome possess variants which are associated with intention tremor. This association is well-known for the hypertrophic type; our report gives an example of the non-hypertrophic type. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/175133/Non_hypertrophic_familial_neuropathy_associated_with_intention_tremor__A_variety_of_Charcot_Marie_Tooth_disease L2 - https://linkinghub.elsevier.com/retrieve/pii/0022-510X(76)90234-3 DB - PRIME DP - Unbound Medicine ER -