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Intake of fruits and vegetables and polymorphisms in DNA repair genes in bladder cancer.
Mutagenesis 2007; 22(4):281-5M

Abstract

The objective is to investigate the relationships between fruit and vegetable intake, DNA repair gene polymorphisms and the risk of bladder cancer. We have analyzed a hospital-based case-control study of 266 individuals with incident, histologically confirmed bladder cancer diagnosed between 1994 and 2003. Controls (n = 193) were patients treated for benign diseases recruited daily in a random fashion from the same hospital as the cases. All cases and controls were interviewed face-to-face for major risk factors, along fruit and vegetable consumption. Odds ratios (ORs) for fruit and vegetable intake and DNA repair gene polymorphisms were adjusted for age and smoking status, using unconditional logistic regression. A statistically significant decreased risk was observed for fruit and vegetable intake above median (versus below the median) [unadjusted OR 0.61, confidence interval (CI) 95% 0.50-0.96 and OR 0.54, CI 95% 0.39-0.80, respectively]; the decreased risk persisted after adjustment for age and cigarette smoking (OR 0.73, CI 95% 0.49-1.01 and OR 0.86, CI 95% 0.56-1.08, respectively). The fruits and vegetables associated with decreased risks included leafy green vegetables, cruciferous vegetables, apples and citrus fruits. We did not find any interactions between DNA repair gene polymorphisms and fruit and vegetable intake. This study found a reduced risk associated with fruit and vegetable intake. No interaction was observed between fruit and vegetable consumption and DNA repair gene polymorphisms.

Authors+Show Affiliations

Unità di Epidemiologia dei Tumori, Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino and CPO-Piemonte, Torino, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17515441

Citation

Sacerdote, Carlotta, et al. "Intake of Fruits and Vegetables and Polymorphisms in DNA Repair Genes in Bladder Cancer." Mutagenesis, vol. 22, no. 4, 2007, pp. 281-5.
Sacerdote C, Matullo G, Polidoro S, et al. Intake of fruits and vegetables and polymorphisms in DNA repair genes in bladder cancer. Mutagenesis. 2007;22(4):281-5.
Sacerdote, C., Matullo, G., Polidoro, S., Gamberini, S., Piazza, A., Karagas, M. R., ... Guarrera, S. (2007). Intake of fruits and vegetables and polymorphisms in DNA repair genes in bladder cancer. Mutagenesis, 22(4), pp. 281-5.
Sacerdote C, et al. Intake of Fruits and Vegetables and Polymorphisms in DNA Repair Genes in Bladder Cancer. Mutagenesis. 2007;22(4):281-5. PubMed PMID: 17515441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of fruits and vegetables and polymorphisms in DNA repair genes in bladder cancer. AU - Sacerdote,Carlotta, AU - Matullo,Giuseppe, AU - Polidoro,Silvia, AU - Gamberini,Sara, AU - Piazza,Alberto, AU - Karagas,Margaret R, AU - Rolle,Luigi, AU - De Stefanis,Paolo, AU - Casetta,Giovanni, AU - Morabito,Francesco, AU - Vineis,Paolo, AU - Guarrera,Simonetta, Y1 - 2007/05/21/ PY - 2007/5/23/pubmed PY - 2007/9/18/medline PY - 2007/5/23/entrez SP - 281 EP - 5 JF - Mutagenesis JO - Mutagenesis VL - 22 IS - 4 N2 - The objective is to investigate the relationships between fruit and vegetable intake, DNA repair gene polymorphisms and the risk of bladder cancer. We have analyzed a hospital-based case-control study of 266 individuals with incident, histologically confirmed bladder cancer diagnosed between 1994 and 2003. Controls (n = 193) were patients treated for benign diseases recruited daily in a random fashion from the same hospital as the cases. All cases and controls were interviewed face-to-face for major risk factors, along fruit and vegetable consumption. Odds ratios (ORs) for fruit and vegetable intake and DNA repair gene polymorphisms were adjusted for age and smoking status, using unconditional logistic regression. A statistically significant decreased risk was observed for fruit and vegetable intake above median (versus below the median) [unadjusted OR 0.61, confidence interval (CI) 95% 0.50-0.96 and OR 0.54, CI 95% 0.39-0.80, respectively]; the decreased risk persisted after adjustment for age and cigarette smoking (OR 0.73, CI 95% 0.49-1.01 and OR 0.86, CI 95% 0.56-1.08, respectively). The fruits and vegetables associated with decreased risks included leafy green vegetables, cruciferous vegetables, apples and citrus fruits. We did not find any interactions between DNA repair gene polymorphisms and fruit and vegetable intake. This study found a reduced risk associated with fruit and vegetable intake. No interaction was observed between fruit and vegetable consumption and DNA repair gene polymorphisms. SN - 0267-8357 UR - https://www.unboundmedicine.com/medline/citation/17515441/Intake_of_fruits_and_vegetables_and_polymorphisms_in_DNA_repair_genes_in_bladder_cancer_ L2 - https://academic.oup.com/mutage/article-lookup/doi/10.1093/mutage/gem014 DB - PRIME DP - Unbound Medicine ER -