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Alcohol consumption, mild cognitive impairment, and progression to dementia.
Neurology. 2007 May 22; 68(21):1790-9.Neur

Abstract

OBJECTIVE

To estimate the impact of alcohol consumption on the incidence of mild cognitive impairment and its progression to dementia.

METHODS

We evaluated the incidence of mild cognitive impairment in 1,445 non-cognitively impaired individuals and its progression to dementia in 121 patients with mild cognitive impairment, aged 65 to 84 years, participating in the Italian Longitudinal Study on Aging, with a 3.5-year follow-up. The level of alcohol consumption was ascertained in the year before the survey. Dementia and mild cognitive impairment were classified using current clinical criteria.

RESULTS

Patients with mild cognitive impairment who were moderate drinkers, i.e., those who consumed less than 1 drink/day (approximately 15 g of alcohol), had a lower rate of progression to dementia than abstainers (hazard ratio [HR] 0.15; 95% CI 0.03 to 0.78). Furthermore, moderate drinkers with mild cognitive impairment who consumed less than 1 drink/day of wine showed a significantly lower rate of progression to dementia than abstainers (HR 0.15; 95% CI 0.03 to 0.77). Finally, there was no significant association between higher levels of drinking (> or =1 drink/day) and rate of progression to dementia in patients with mild cognitive impairment vs abstainers. No significant associations were found between any levels of drinking and the incidence of mild cognitive impairment in non-cognitively impaired individuals vs abstainers.

CONCLUSIONS

In patients with mild cognitive impairment, up to 1 drink/day of alcohol or wine may decrease the rate of progression to dementia.

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Authors+Show Affiliations

Solfrizzi V
Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Bari, Italy. v.solfrizzi@geriatria.uniba.it
D'Introno A
No affiliation info available
Colacicco AM
No affiliation info available
Capurso C
No affiliation info available
Del Parigi A
No affiliation info available
Baldassarre G
No affiliation info available
Scapicchio P
No affiliation info available
Scafato E
No affiliation info available
Amodio M
No affiliation info available
Capurso A
No affiliation info available
Panza F
No affiliation info available
Italian Longitudinal Study on Aging Working Group
No affiliation info available

MeSH

Age FactorsAgedAged, 80 and overAgingAlcohol DrinkingCentral Nervous System DepressantsCognition DisordersCohort StudiesDementiaDisease ProgressionDose-Response Relationship, DrugDrug Administration ScheduleEthanolFemaleHumansItalyLongitudinal StudiesMaleNeuroprotective AgentsTimeWine

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17515541

Citation

Solfrizzi, V, et al. "Alcohol Consumption, Mild Cognitive Impairment, and Progression to Dementia." Neurology, vol. 68, no. 21, 2007, pp. 1790-9.
Solfrizzi V, D'Introno A, Colacicco AM, et al. Alcohol consumption, mild cognitive impairment, and progression to dementia. Neurology. 2007;68(21):1790-9.
Solfrizzi, V., D'Introno, A., Colacicco, A. M., Capurso, C., Del Parigi, A., Baldassarre, G., Scapicchio, P., Scafato, E., Amodio, M., Capurso, A., & Panza, F. (2007). Alcohol consumption, mild cognitive impairment, and progression to dementia. Neurology, 68(21), 1790-9.
Solfrizzi V, et al. Alcohol Consumption, Mild Cognitive Impairment, and Progression to Dementia. Neurology. 2007 May 22;68(21):1790-9. PubMed PMID: 17515541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption, mild cognitive impairment, and progression to dementia. AU - Solfrizzi,V, AU - D'Introno,A, AU - Colacicco,A M, AU - Capurso,C, AU - Del Parigi,A, AU - Baldassarre,G, AU - Scapicchio,P, AU - Scafato,E, AU - Amodio,M, AU - Capurso,A, AU - Panza,F, AU - ,, PY - 2007/5/23/pubmed PY - 2007/6/22/medline PY - 2007/5/23/entrez SP - 1790 EP - 9 JF - Neurology JO - Neurology VL - 68 IS - 21 N2 - OBJECTIVE: To estimate the impact of alcohol consumption on the incidence of mild cognitive impairment and its progression to dementia. METHODS: We evaluated the incidence of mild cognitive impairment in 1,445 non-cognitively impaired individuals and its progression to dementia in 121 patients with mild cognitive impairment, aged 65 to 84 years, participating in the Italian Longitudinal Study on Aging, with a 3.5-year follow-up. The level of alcohol consumption was ascertained in the year before the survey. Dementia and mild cognitive impairment were classified using current clinical criteria. RESULTS: Patients with mild cognitive impairment who were moderate drinkers, i.e., those who consumed less than 1 drink/day (approximately 15 g of alcohol), had a lower rate of progression to dementia than abstainers (hazard ratio [HR] 0.15; 95% CI 0.03 to 0.78). Furthermore, moderate drinkers with mild cognitive impairment who consumed less than 1 drink/day of wine showed a significantly lower rate of progression to dementia than abstainers (HR 0.15; 95% CI 0.03 to 0.77). Finally, there was no significant association between higher levels of drinking (> or =1 drink/day) and rate of progression to dementia in patients with mild cognitive impairment vs abstainers. No significant associations were found between any levels of drinking and the incidence of mild cognitive impairment in non-cognitively impaired individuals vs abstainers. CONCLUSIONS: In patients with mild cognitive impairment, up to 1 drink/day of alcohol or wine may decrease the rate of progression to dementia. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/17515541/Alcohol_consumption_mild_cognitive_impairment_and_progression_to_dementia_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=17515541 DB - PRIME DP - Unbound Medicine ER -