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Inhibitory effects of glycitein on hydrogen peroxide induced cell damage by scavenging reactive oxygen species and inhibiting c-Jun N-terminal kinase.
Free Radic Res. 2007 Jun; 41(6):720-9.FR

Abstract

The present study investigated the cytoprotective properties of glycitein, a metabolite formed by the transformation of glycitin by intestinal microflora, against oxidative stress. Glycitein was found to scavenge intracellular reactive oxygen species (ROS), and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and thereby preventing lipid peroxidation and DNA damage. Glycitein inhibited apoptosis of Chinese hamster lung fibroblast (V79-4) cells exposed to hydrogen peroxide (H(2)O(2)) via radical scavenging activity. Glycitein abrogated the activation of c-Jun N-terminal kinase (JNK) induced by H(2)O(2) treatment and inhibited DNA binding activity of activator protein-1 (AP-1), a downstream transcription factor of JNK. Taken together, these findings suggest that glycitein protected H(2)O(2) induced cell death in V79-4 cells by inhibiting ROS generation and JNK activation.

Authors+Show Affiliations

Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University, Jeju-si, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17516245

Citation

Kang, Kyoung Ah, et al. "Inhibitory Effects of Glycitein On Hydrogen Peroxide Induced Cell Damage By Scavenging Reactive Oxygen Species and Inhibiting c-Jun N-terminal Kinase." Free Radical Research, vol. 41, no. 6, 2007, pp. 720-9.
Kang KA, Zhang R, Piao MJ, et al. Inhibitory effects of glycitein on hydrogen peroxide induced cell damage by scavenging reactive oxygen species and inhibiting c-Jun N-terminal kinase. Free Radic Res. 2007;41(6):720-9.
Kang, K. A., Zhang, R., Piao, M. J., Lee, K. H., Kim, B. J., Kim, S. Y., Kim, H. S., Kim, D. H., You, H. J., & Hyun, J. W. (2007). Inhibitory effects of glycitein on hydrogen peroxide induced cell damage by scavenging reactive oxygen species and inhibiting c-Jun N-terminal kinase. Free Radical Research, 41(6), 720-9.
Kang KA, et al. Inhibitory Effects of Glycitein On Hydrogen Peroxide Induced Cell Damage By Scavenging Reactive Oxygen Species and Inhibiting c-Jun N-terminal Kinase. Free Radic Res. 2007;41(6):720-9. PubMed PMID: 17516245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effects of glycitein on hydrogen peroxide induced cell damage by scavenging reactive oxygen species and inhibiting c-Jun N-terminal kinase. AU - Kang,Kyoung Ah, AU - Zhang,Rui, AU - Piao,Mei Jing, AU - Lee,Kyoung Hwa, AU - Kim,Bum Joon, AU - Kim,So Young, AU - Kim,Hee Sun, AU - Kim,Dong Hyun, AU - You,Ho Jin, AU - Hyun,Jin Won, PY - 2007/5/23/pubmed PY - 2007/8/8/medline PY - 2007/5/23/entrez SP - 720 EP - 9 JF - Free radical research JO - Free Radic Res VL - 41 IS - 6 N2 - The present study investigated the cytoprotective properties of glycitein, a metabolite formed by the transformation of glycitin by intestinal microflora, against oxidative stress. Glycitein was found to scavenge intracellular reactive oxygen species (ROS), and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and thereby preventing lipid peroxidation and DNA damage. Glycitein inhibited apoptosis of Chinese hamster lung fibroblast (V79-4) cells exposed to hydrogen peroxide (H(2)O(2)) via radical scavenging activity. Glycitein abrogated the activation of c-Jun N-terminal kinase (JNK) induced by H(2)O(2) treatment and inhibited DNA binding activity of activator protein-1 (AP-1), a downstream transcription factor of JNK. Taken together, these findings suggest that glycitein protected H(2)O(2) induced cell death in V79-4 cells by inhibiting ROS generation and JNK activation. SN - 1071-5762 UR - https://www.unboundmedicine.com/medline/citation/17516245/Inhibitory_effects_of_glycitein_on_hydrogen_peroxide_induced_cell_damage_by_scavenging_reactive_oxygen_species_and_inhibiting_c_Jun_N_terminal_kinase_ L2 - https://www.tandfonline.com/doi/full/10.1080/10715760701241618 DB - PRIME DP - Unbound Medicine ER -