Tags

Type your tag names separated by a space and hit enter

Antimicrobial activity of seven hypericum entities from central Italy.
Planta Med. 2007 Jun; 73(6):564-6.PM

Abstract

Methanol-acetone extracts from aerial parts of seven entities of the genus Hypericum [H. perforatum L. subsp. perforatum, H. perforatum L. subsp. veronense (Schrank) Ces., H. montanum L., H. hyssopifolium Chaix, H. hirsutum L., H. hircinum L. subsp. majus (Aiton) N. Robson, H. tetrapterum Fr.] growing in the Appennino Umbro-Marchigiano (central Italy) were tested in vitro for their antimicrobial activity against two Gram-positive bacteria (Staphylococcus aureus and Enterococcus faecalis), two Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and the yeast Candida albicans, by the Kirby-Bauer agar diffusion method. The two H. perforatum subspecies were particularly active against Gram-positive and Gram-negative bacteria, supporting the use of these plants in the traditional medicine of central Italy to treat wounds, skin and infectious diseases. However significant values of inhibition were given also by H. hirsutum against S. aureus and P. aeruginosa, and by H. hyssopifolium, H. hircinum subsp. majus and H. tetrapterum against C. albicans. These results suggest that hypericin and hyperforin are the main components responsible for antimicrobial activity, but not the only ones, as other extracts, showing a low level of these compounds, possess evident activity. Isolation of pure compounds from the most active extracts is in progress.

Authors+Show Affiliations

University of Camerino, Faculty of Sciences and Technology, Department of Comparative Morphology and Biochemistry, Camerino, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17516331

Citation

Cecchini, Cinzia, et al. "Antimicrobial Activity of Seven Hypericum Entities From Central Italy." Planta Medica, vol. 73, no. 6, 2007, pp. 564-6.
Cecchini C, Cresci A, Coman MM, et al. Antimicrobial activity of seven hypericum entities from central Italy. Planta Med. 2007;73(6):564-6.
Cecchini, C., Cresci, A., Coman, M. M., Ricciutelli, M., Sagratini, G., Vittori, S., Lucarini, D., & Maggi, F. (2007). Antimicrobial activity of seven hypericum entities from central Italy. Planta Medica, 73(6), 564-6.
Cecchini C, et al. Antimicrobial Activity of Seven Hypericum Entities From Central Italy. Planta Med. 2007;73(6):564-6. PubMed PMID: 17516331.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial activity of seven hypericum entities from central Italy. AU - Cecchini,Cinzia, AU - Cresci,Alberto, AU - Coman,Maria Magdalena, AU - Ricciutelli,Massimo, AU - Sagratini,Gianni, AU - Vittori,Sauro, AU - Lucarini,Domenico, AU - Maggi,Filippo, Y1 - 2007/05/22/ PY - 2007/5/23/pubmed PY - 2007/8/8/medline PY - 2007/5/23/entrez SP - 564 EP - 6 JF - Planta medica JO - Planta Med VL - 73 IS - 6 N2 - Methanol-acetone extracts from aerial parts of seven entities of the genus Hypericum [H. perforatum L. subsp. perforatum, H. perforatum L. subsp. veronense (Schrank) Ces., H. montanum L., H. hyssopifolium Chaix, H. hirsutum L., H. hircinum L. subsp. majus (Aiton) N. Robson, H. tetrapterum Fr.] growing in the Appennino Umbro-Marchigiano (central Italy) were tested in vitro for their antimicrobial activity against two Gram-positive bacteria (Staphylococcus aureus and Enterococcus faecalis), two Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and the yeast Candida albicans, by the Kirby-Bauer agar diffusion method. The two H. perforatum subspecies were particularly active against Gram-positive and Gram-negative bacteria, supporting the use of these plants in the traditional medicine of central Italy to treat wounds, skin and infectious diseases. However significant values of inhibition were given also by H. hirsutum against S. aureus and P. aeruginosa, and by H. hyssopifolium, H. hircinum subsp. majus and H. tetrapterum against C. albicans. These results suggest that hypericin and hyperforin are the main components responsible for antimicrobial activity, but not the only ones, as other extracts, showing a low level of these compounds, possess evident activity. Isolation of pure compounds from the most active extracts is in progress. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/17516331/Antimicrobial_activity_of_seven_hypericum_entities_from_central_Italy_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-967198 DB - PRIME DP - Unbound Medicine ER -