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Seroepidemiology of hepatitis E virus in patients with non-A, non-B, non-C hepatitis in Hungary.
J Med Virol. 2007 Jul; 79(7):927-30.JM

Abstract

Many cases of acute hepatitis remain undiagnosed and the hepatitis E virus (HEV) is emerging in industrialized countries. The aim of this study was to assess the role HEV as causative agent in acute non-A, non-B, and non-C hepatitis patients in Hungary. 10.5% of the 264 acute non-A, non-B, and non-C hepatitis patients tested had anti-HEV IgG and 1.9% had anti-HEV IgM as tested by ELISA. After confirmation by Western blot 6.1% of the acute non-A, non-B, and non-C hepatitis patients had anti-HEV IgG antibodies only and 1.1% of the patients had both IgG and IgM. All 19 patients that were positive for anti-HEV IgG and/or IgM tested negative for HEV RNA by PCR. Only a small proportion of the acute hepatitis cases in the southwest of Hungary are assumed to be attributed to HEV infection, however, hepatitis E should be considered along with hepatitis A, B, and C in the diagnosis of acute hepatitis.

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Authors+Show Affiliations

Haagsman A
Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Reuter G
No affiliation info available
Duizer E
No affiliation info available
Nagy G
No affiliation info available
Herremans T
No affiliation info available
Koopmans M
No affiliation info available
Szücs G
No affiliation info available

MeSH

Acute DiseaseAdultAgedAged, 80 and overFemaleHepatitis AntibodiesHepatitis EHepatitis E virusHumansHungaryImmunoglobulin GImmunoglobulin MMaleMiddle AgedMolecular EpidemiologySeroepidemiologic Studies

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17516521

Citation

Haagsman, Annika, et al. "Seroepidemiology of Hepatitis E Virus in Patients With non-A, non-B, non-C Hepatitis in Hungary." Journal of Medical Virology, vol. 79, no. 7, 2007, pp. 927-30.
Haagsman A, Reuter G, Duizer E, et al. Seroepidemiology of hepatitis E virus in patients with non-A, non-B, non-C hepatitis in Hungary. J Med Virol. 2007;79(7):927-30.
Haagsman, A., Reuter, G., Duizer, E., Nagy, G., Herremans, T., Koopmans, M., & Szücs, G. (2007). Seroepidemiology of hepatitis E virus in patients with non-A, non-B, non-C hepatitis in Hungary. Journal of Medical Virology, 79(7), 927-30.
Haagsman A, et al. Seroepidemiology of Hepatitis E Virus in Patients With non-A, non-B, non-C Hepatitis in Hungary. J Med Virol. 2007;79(7):927-30. PubMed PMID: 17516521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seroepidemiology of hepatitis E virus in patients with non-A, non-B, non-C hepatitis in Hungary. AU - Haagsman,Annika, AU - Reuter,Gábor, AU - Duizer,Erwin, AU - Nagy,Gyuláné, AU - Herremans,Tineke, AU - Koopmans,Marion, AU - Szücs,György, PY - 2007/5/23/pubmed PY - 2007/8/8/medline PY - 2007/5/23/entrez SP - 927 EP - 30 JF - Journal of medical virology JO - J Med Virol VL - 79 IS - 7 N2 - Many cases of acute hepatitis remain undiagnosed and the hepatitis E virus (HEV) is emerging in industrialized countries. The aim of this study was to assess the role HEV as causative agent in acute non-A, non-B, and non-C hepatitis patients in Hungary. 10.5% of the 264 acute non-A, non-B, and non-C hepatitis patients tested had anti-HEV IgG and 1.9% had anti-HEV IgM as tested by ELISA. After confirmation by Western blot 6.1% of the acute non-A, non-B, and non-C hepatitis patients had anti-HEV IgG antibodies only and 1.1% of the patients had both IgG and IgM. All 19 patients that were positive for anti-HEV IgG and/or IgM tested negative for HEV RNA by PCR. Only a small proportion of the acute hepatitis cases in the southwest of Hungary are assumed to be attributed to HEV infection, however, hepatitis E should be considered along with hepatitis A, B, and C in the diagnosis of acute hepatitis. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/17516521/Seroepidemiology_of_hepatitis_E_virus_in_patients_with_non_A_non_B_non_C_hepatitis_in_Hungary_ L2 - https://doi.org/10.1002/jmv.20869 DB - PRIME DP - Unbound Medicine ER -