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Seroepidemiology of hepatitis E virus in patients with non-A, non-B, non-C hepatitis in Hungary.
J Med Virol. 2007 Jul; 79(7):927-30.JM

Abstract

Many cases of acute hepatitis remain undiagnosed and the hepatitis E virus (HEV) is emerging in industrialized countries. The aim of this study was to assess the role HEV as causative agent in acute non-A, non-B, and non-C hepatitis patients in Hungary. 10.5% of the 264 acute non-A, non-B, and non-C hepatitis patients tested had anti-HEV IgG and 1.9% had anti-HEV IgM as tested by ELISA. After confirmation by Western blot 6.1% of the acute non-A, non-B, and non-C hepatitis patients had anti-HEV IgG antibodies only and 1.1% of the patients had both IgG and IgM. All 19 patients that were positive for anti-HEV IgG and/or IgM tested negative for HEV RNA by PCR. Only a small proportion of the acute hepatitis cases in the southwest of Hungary are assumed to be attributed to HEV infection, however, hepatitis E should be considered along with hepatitis A, B, and C in the diagnosis of acute hepatitis.

Authors+Show Affiliations

Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17516521

Citation

Haagsman, Annika, et al. "Seroepidemiology of Hepatitis E Virus in Patients With non-A, non-B, non-C Hepatitis in Hungary." Journal of Medical Virology, vol. 79, no. 7, 2007, pp. 927-30.
Haagsman A, Reuter G, Duizer E, et al. Seroepidemiology of hepatitis E virus in patients with non-A, non-B, non-C hepatitis in Hungary. J Med Virol. 2007;79(7):927-30.
Haagsman, A., Reuter, G., Duizer, E., Nagy, G., Herremans, T., Koopmans, M., & Szücs, G. (2007). Seroepidemiology of hepatitis E virus in patients with non-A, non-B, non-C hepatitis in Hungary. Journal of Medical Virology, 79(7), 927-30.
Haagsman A, et al. Seroepidemiology of Hepatitis E Virus in Patients With non-A, non-B, non-C Hepatitis in Hungary. J Med Virol. 2007;79(7):927-30. PubMed PMID: 17516521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seroepidemiology of hepatitis E virus in patients with non-A, non-B, non-C hepatitis in Hungary. AU - Haagsman,Annika, AU - Reuter,Gábor, AU - Duizer,Erwin, AU - Nagy,Gyuláné, AU - Herremans,Tineke, AU - Koopmans,Marion, AU - Szücs,György, PY - 2007/5/23/pubmed PY - 2007/8/8/medline PY - 2007/5/23/entrez SP - 927 EP - 30 JF - Journal of medical virology JO - J Med Virol VL - 79 IS - 7 N2 - Many cases of acute hepatitis remain undiagnosed and the hepatitis E virus (HEV) is emerging in industrialized countries. The aim of this study was to assess the role HEV as causative agent in acute non-A, non-B, and non-C hepatitis patients in Hungary. 10.5% of the 264 acute non-A, non-B, and non-C hepatitis patients tested had anti-HEV IgG and 1.9% had anti-HEV IgM as tested by ELISA. After confirmation by Western blot 6.1% of the acute non-A, non-B, and non-C hepatitis patients had anti-HEV IgG antibodies only and 1.1% of the patients had both IgG and IgM. All 19 patients that were positive for anti-HEV IgG and/or IgM tested negative for HEV RNA by PCR. Only a small proportion of the acute hepatitis cases in the southwest of Hungary are assumed to be attributed to HEV infection, however, hepatitis E should be considered along with hepatitis A, B, and C in the diagnosis of acute hepatitis. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/17516521/Seroepidemiology_of_hepatitis_E_virus_in_patients_with_non_A_non_B_non_C_hepatitis_in_Hungary_ L2 - https://doi.org/10.1002/jmv.20869 DB - PRIME DP - Unbound Medicine ER -