Tags

Type your tag names separated by a space and hit enter

Effect of lycopene on nephrotoxicity induced by mercuric chloride in rats.
Basic Clin Pharmacol Toxicol. 2007 Jun; 100(6):398-402.BC

Abstract

Oxidative stress is an important molecular mechanism for kidney injury in mercury poisoning. We studied lycopene, a potent carotenoid found in tomatoes due to its large antioxidant properties, and also evaluated the ability of lycopene to prevent HgCl(2) nephrotoxicity. Rats were injected with HgCl(2) (0 or 5 mg/kg body weight, subcutaneously) 6 hr after lycopene administration (0, 10, 25 or 50 mg/kg by gavage) and were killed 12 hr after HgCl(2) exposure. HgCl(2)-induced inhibition of delta-aminolevulinate dehydratase activity (approximately 35%) and increase of lipid peroxidation in kidney (approximately 37%) were prevented by lycopene. However, lycopene did not prevent the increase of plasma creatinine levels (approximately 123%) and renal tubular necrosis induced by HgCl(2). Glutathione peroxidase and catalase activities were enhanced (approximately 71% and approximately 41%), while superoxide dismutase activity was depressed (approximately 44%) in HgCl(2)-treated rats when compared to control and these effects were prevented by lycopene. Our results indicate that although lycopene did not prevent HgCl(2)-induced renal failure, it could play a beneficial role against HgCl(2) toxicity by preventing lipid peroxidation and changes in the activity of delta-aminolevulinate dehydratase and antioxidant enzymes.

Authors+Show Affiliations

Post-graduate Program on Biochemical Toxicology, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17516994

Citation

Augusti, Paula R., et al. "Effect of Lycopene On Nephrotoxicity Induced By Mercuric Chloride in Rats." Basic & Clinical Pharmacology & Toxicology, vol. 100, no. 6, 2007, pp. 398-402.
Augusti PR, Conterato GM, Somacal S, et al. Effect of lycopene on nephrotoxicity induced by mercuric chloride in rats. Basic Clin Pharmacol Toxicol. 2007;100(6):398-402.
Augusti, P. R., Conterato, G. M., Somacal, S., Einsfeld, L., Ramos, A. T., Hosomi, F. Y., Graça, D. L., & Emanuelli, T. (2007). Effect of lycopene on nephrotoxicity induced by mercuric chloride in rats. Basic & Clinical Pharmacology & Toxicology, 100(6), 398-402.
Augusti PR, et al. Effect of Lycopene On Nephrotoxicity Induced By Mercuric Chloride in Rats. Basic Clin Pharmacol Toxicol. 2007;100(6):398-402. PubMed PMID: 17516994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of lycopene on nephrotoxicity induced by mercuric chloride in rats. AU - Augusti,Paula R, AU - Conterato,Greicy M M, AU - Somacal,Sabrina, AU - Einsfeld,Lídia, AU - Ramos,Adriano T, AU - Hosomi,Fernando Y M, AU - Graça,Dominguita L, AU - Emanuelli,Tatiana, PY - 2007/5/23/pubmed PY - 2007/9/8/medline PY - 2007/5/23/entrez SP - 398 EP - 402 JF - Basic & clinical pharmacology & toxicology JO - Basic Clin Pharmacol Toxicol VL - 100 IS - 6 N2 - Oxidative stress is an important molecular mechanism for kidney injury in mercury poisoning. We studied lycopene, a potent carotenoid found in tomatoes due to its large antioxidant properties, and also evaluated the ability of lycopene to prevent HgCl(2) nephrotoxicity. Rats were injected with HgCl(2) (0 or 5 mg/kg body weight, subcutaneously) 6 hr after lycopene administration (0, 10, 25 or 50 mg/kg by gavage) and were killed 12 hr after HgCl(2) exposure. HgCl(2)-induced inhibition of delta-aminolevulinate dehydratase activity (approximately 35%) and increase of lipid peroxidation in kidney (approximately 37%) were prevented by lycopene. However, lycopene did not prevent the increase of plasma creatinine levels (approximately 123%) and renal tubular necrosis induced by HgCl(2). Glutathione peroxidase and catalase activities were enhanced (approximately 71% and approximately 41%), while superoxide dismutase activity was depressed (approximately 44%) in HgCl(2)-treated rats when compared to control and these effects were prevented by lycopene. Our results indicate that although lycopene did not prevent HgCl(2)-induced renal failure, it could play a beneficial role against HgCl(2) toxicity by preventing lipid peroxidation and changes in the activity of delta-aminolevulinate dehydratase and antioxidant enzymes. SN - 1742-7835 UR - https://www.unboundmedicine.com/medline/citation/17516994/Effect_of_lycopene_on_nephrotoxicity_induced_by_mercuric_chloride_in_rats_ L2 - https://doi.org/10.1111/j.1742-7843.2007.00067.x DB - PRIME DP - Unbound Medicine ER -