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Alopecia areata in a rhesus monkey (Macaca mulatta).
J Med Primatol. 2007 Jun; 36(3):124-30.JM

Abstract

BACKGROUND

A 14-year-old female rhesus monkey (Macaca mulatta) of Chinese origin has been suffering from alopecia universalis since childhood.

METHODS

Recently, the health status of the animal was recorded comprehensively by detailed clinical examination including hematology and serology supplemented by histological and immunohistochemical investigations of skin biopsies and molecular biological techniques to clarify the causes of the persistent hair loss.

RESULTS AND CONCLUSIONS

The hairless gene (hr) nonsense mutation was ruled out by polymerase chain reaction and by sequencing of the corresponding gene. Histological examinations revealed a prominent chronic lymphocytic perifolliculitis and folliculitis affecting anagen stage hair follicles as well as miniaturized hair follicles. Immunohistochemistry using the antibodies CD3, CD20 and CD4 confirmed the diagnosis of a T-cell-mediated autoimmune disease resembling alopecia areata universalis in humans.

Authors+Show Affiliations

Beardi B
Department of Infectious Pathology, German Primate Center (GPC), Göttingen, Germany. dr.baerbel.beardi@t-online.de
Wanert F
No affiliation info available
Zöller M
No affiliation info available
Freyschmidt-Paul P
No affiliation info available
Bodemer W
No affiliation info available
Kaup FJ
No affiliation info available

MeSH

Alopecia AreataAnimalsAntibodiesAntigens, CDAutoimmune DiseasesDNA PrimersFemaleHair FollicleMacaca mulattaMonkey DiseasesNailsPolymerase Chain ReactionSkinThyroid Hormones

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17517086

Citation

Beardi, B, et al. "Alopecia Areata in a Rhesus Monkey (Macaca Mulatta)." Journal of Medical Primatology, vol. 36, no. 3, 2007, pp. 124-30.
Beardi B, Wanert F, Zöller M, et al. Alopecia areata in a rhesus monkey (Macaca mulatta). J Med Primatol. 2007;36(3):124-30.
Beardi, B., Wanert, F., Zöller, M., Freyschmidt-Paul, P., Bodemer, W., & Kaup, F. J. (2007). Alopecia areata in a rhesus monkey (Macaca mulatta). Journal of Medical Primatology, 36(3), 124-30.
Beardi B, et al. Alopecia Areata in a Rhesus Monkey (Macaca Mulatta). J Med Primatol. 2007;36(3):124-30. PubMed PMID: 17517086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alopecia areata in a rhesus monkey (Macaca mulatta). AU - Beardi,B, AU - Wanert,F, AU - Zöller,M, AU - Freyschmidt-Paul,P, AU - Bodemer,W, AU - Kaup,F-J, PY - 2007/5/23/pubmed PY - 2007/9/7/medline PY - 2007/5/23/entrez SP - 124 EP - 30 JF - Journal of medical primatology JO - J Med Primatol VL - 36 IS - 3 N2 - BACKGROUND: A 14-year-old female rhesus monkey (Macaca mulatta) of Chinese origin has been suffering from alopecia universalis since childhood. METHODS: Recently, the health status of the animal was recorded comprehensively by detailed clinical examination including hematology and serology supplemented by histological and immunohistochemical investigations of skin biopsies and molecular biological techniques to clarify the causes of the persistent hair loss. RESULTS AND CONCLUSIONS: The hairless gene (hr) nonsense mutation was ruled out by polymerase chain reaction and by sequencing of the corresponding gene. Histological examinations revealed a prominent chronic lymphocytic perifolliculitis and folliculitis affecting anagen stage hair follicles as well as miniaturized hair follicles. Immunohistochemistry using the antibodies CD3, CD20 and CD4 confirmed the diagnosis of a T-cell-mediated autoimmune disease resembling alopecia areata universalis in humans. SN - 0047-2565 UR - https://www.unboundmedicine.com/medline/citation/17517086/Alopecia_areata_in_a_rhesus_monkey__Macaca_mulatta__ L2 - https://doi.org/10.1111/j.1600-0684.2007.00212.x DB - PRIME DP - Unbound Medicine ER -