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Do cardiovascular risk factors confer the same risk for cardiovascular outcomes in rheumatoid arthritis patients as in non-rheumatoid arthritis patients?
Ann Rheum Dis. 2008 Jan; 67(1):64-9.AR

Abstract

OBJECTIVE

To compare the frequency of traditional cardiovascular (CV) risk factors in rheumatoid arthritis (RA) compared to non-RA subjects, and examine their impact on the risk of developing selected CV events (myocardial infarction (MI), heart failure (HF) and CV death) in these two groups.

METHODS

We examined a population-based incidence cohort of subjects with RA (defined according to the 1987 American College of Rheumatology criteria), and an age- and sex-matched non-RA cohort. All subjects were followed longitudinally through their complete community medical records, until death, migration, or 1 January 2001. Clinical CV risk factors and outcomes were defined using validated criteria. The chi2 test was used to compare the frequency of each CV risk factor at baseline. Person-years methods were used to estimate the rate of occurrence of each CV risk factor during follow-up. Cox models were used to examine the influence of CV risk factors on the development of CV outcomes.

RESULTS

A total of 603 RA and 603 non-RA subjects (73% female; mean age 58 years) were followed for a mean of 15 and 17 years (total: 8842 and 10,101 person-years), respectively. At baseline, RA subjects were significantly more likely to be former or current smokers when compared to non-RA subjects (p<0.001). Male gender, smoking, and personal cardiac history had weaker associations with CV events among RA subjects, compared to non-RA subjects. There was no significant difference between RA and non-RA subjects in the risk imparted with respect to the other CV risk factors (ie, family cardiac history, hypertension, dyslipidaemia, body mass index, or diabetes mellitus).

CONCLUSION

While some traditional CV risk factors imparted similar risk among RA compared with non-RA subjects, others (ie, male gender, smoking and personal cardiac history) imparted significantly less risk for the development of CV disease. These differences in the overall impact of traditional CV risk factors suggest that strategies to prevent CV disease and mortality focused solely on controlling traditional CV risk factors may be relatively less beneficial in RA subjects than in the general population. Further research is needed to determine optimal approaches to reducing CV morbidity and mortality in persons with RA.

Authors+Show Affiliations

Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17517756

Citation

Gonzalez, A, et al. "Do Cardiovascular Risk Factors Confer the Same Risk for Cardiovascular Outcomes in Rheumatoid Arthritis Patients as in Non-rheumatoid Arthritis Patients?" Annals of the Rheumatic Diseases, vol. 67, no. 1, 2008, pp. 64-9.
Gonzalez A, Maradit Kremers H, Crowson CS, et al. Do cardiovascular risk factors confer the same risk for cardiovascular outcomes in rheumatoid arthritis patients as in non-rheumatoid arthritis patients? Ann Rheum Dis. 2008;67(1):64-9.
Gonzalez, A., Maradit Kremers, H., Crowson, C. S., Ballman, K. V., Roger, V. L., Jacobsen, S. J., O'Fallon, W. M., & Gabriel, S. E. (2008). Do cardiovascular risk factors confer the same risk for cardiovascular outcomes in rheumatoid arthritis patients as in non-rheumatoid arthritis patients? Annals of the Rheumatic Diseases, 67(1), 64-9.
Gonzalez A, et al. Do Cardiovascular Risk Factors Confer the Same Risk for Cardiovascular Outcomes in Rheumatoid Arthritis Patients as in Non-rheumatoid Arthritis Patients. Ann Rheum Dis. 2008;67(1):64-9. PubMed PMID: 17517756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Do cardiovascular risk factors confer the same risk for cardiovascular outcomes in rheumatoid arthritis patients as in non-rheumatoid arthritis patients? AU - Gonzalez,A, AU - Maradit Kremers,H, AU - Crowson,C S, AU - Ballman,K V, AU - Roger,V L, AU - Jacobsen,S J, AU - O'Fallon,W M, AU - Gabriel,S E, Y1 - 2007/05/21/ PY - 2007/5/23/pubmed PY - 2008/1/15/medline PY - 2007/5/23/entrez SP - 64 EP - 9 JF - Annals of the rheumatic diseases JO - Ann Rheum Dis VL - 67 IS - 1 N2 - OBJECTIVE: To compare the frequency of traditional cardiovascular (CV) risk factors in rheumatoid arthritis (RA) compared to non-RA subjects, and examine their impact on the risk of developing selected CV events (myocardial infarction (MI), heart failure (HF) and CV death) in these two groups. METHODS: We examined a population-based incidence cohort of subjects with RA (defined according to the 1987 American College of Rheumatology criteria), and an age- and sex-matched non-RA cohort. All subjects were followed longitudinally through their complete community medical records, until death, migration, or 1 January 2001. Clinical CV risk factors and outcomes were defined using validated criteria. The chi2 test was used to compare the frequency of each CV risk factor at baseline. Person-years methods were used to estimate the rate of occurrence of each CV risk factor during follow-up. Cox models were used to examine the influence of CV risk factors on the development of CV outcomes. RESULTS: A total of 603 RA and 603 non-RA subjects (73% female; mean age 58 years) were followed for a mean of 15 and 17 years (total: 8842 and 10,101 person-years), respectively. At baseline, RA subjects were significantly more likely to be former or current smokers when compared to non-RA subjects (p<0.001). Male gender, smoking, and personal cardiac history had weaker associations with CV events among RA subjects, compared to non-RA subjects. There was no significant difference between RA and non-RA subjects in the risk imparted with respect to the other CV risk factors (ie, family cardiac history, hypertension, dyslipidaemia, body mass index, or diabetes mellitus). CONCLUSION: While some traditional CV risk factors imparted similar risk among RA compared with non-RA subjects, others (ie, male gender, smoking and personal cardiac history) imparted significantly less risk for the development of CV disease. These differences in the overall impact of traditional CV risk factors suggest that strategies to prevent CV disease and mortality focused solely on controlling traditional CV risk factors may be relatively less beneficial in RA subjects than in the general population. Further research is needed to determine optimal approaches to reducing CV morbidity and mortality in persons with RA. SN - 1468-2060 UR - https://www.unboundmedicine.com/medline/citation/17517756/Do_cardiovascular_risk_factors_confer_the_same_risk_for_cardiovascular_outcomes_in_rheumatoid_arthritis_patients_as_in_non_rheumatoid_arthritis_patients L2 - https://ard.bmj.com/lookup/pmidlookup?view=long&amp;pmid=17517756 DB - PRIME DP - Unbound Medicine ER -