Texture anisotropy of the brain's white matter as revealed by anatomical MRI.IEEE Trans Med Imaging 2007; 26(5):678-85IT
The purpose of this work was to study specific texture properties of the brain's white matter (WM) based on conventional high-resolution T1-weighted magnetic resonance imaging (MRI) datasets. Quantitative parameters anisotropy and laminarity were derived from 3-D texture analysis. Differences in WM texture associated with gender were evaluated on an age-matched sample of 210 young healthy subjects (mean age 24.8, SD 3.97 years, 103 males and 107 females). Changes of WM texture with age were studied using 112 MRI-T1 datasets of healthy subjects aged 16 to 70 years (57 males and 55 females). Both texture measures indicated a "more regular" WM structure in females (p < 10(-6)). An age-related deterioration of WM structure manifests itself as a remarkable decline of both parameters (p < 10(-6)) that is more prominent in females (p < 10(-6)) than in males (p = 0.02). Texture analysis of anatomical MRI-T1 brain datasets provides quantitative information about macroscopic WM characteristics and helps discriminating between normal and pathological aging.