Highly enantioselective organocatalytic direct aldol reaction in an aqueous medium.Org Lett. 2007 Jun 21; 9(13):2593-5.OL
Abstract
We have demonstrated that small organic molecules 1 and 2 catalyzed the direct aldol reaction of both acyclic and cyclic ketones with different aldehydes in an excess of water/brine. Excellent enantioselectivities up to >99% and diastereoselectivities up to 99% with very good yields were obtained by using much lower catalyst loadings (0.5 mol %).
Pub Type(s)
Journal Article
Language
eng
PubMed ID
17518481
Citation
Maya, Vishnu, et al. "Highly Enantioselective Organocatalytic Direct Aldol Reaction in an Aqueous Medium." Organic Letters, vol. 9, no. 13, 2007, pp. 2593-5.
Maya V, Raj M, Singh VK. Highly enantioselective organocatalytic direct aldol reaction in an aqueous medium. Org Lett. 2007;9(13):2593-5.
Maya, V., Raj, M., & Singh, V. K. (2007). Highly enantioselective organocatalytic direct aldol reaction in an aqueous medium. Organic Letters, 9(13), 2593-5.
Maya V, Raj M, Singh VK. Highly Enantioselective Organocatalytic Direct Aldol Reaction in an Aqueous Medium. Org Lett. 2007 Jun 21;9(13):2593-5. PubMed PMID: 17518481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Highly enantioselective organocatalytic direct aldol reaction in an aqueous medium.
AU - Maya,Vishnu,
AU - Raj,Monika,
AU - Singh,Vinod K,
Y1 - 2007/05/23/
PY - 2007/5/24/pubmed
PY - 2007/5/24/medline
PY - 2007/5/24/entrez
SP - 2593
EP - 5
JF - Organic letters
JO - Org Lett
VL - 9
IS - 13
N2 - We have demonstrated that small organic molecules 1 and 2 catalyzed the direct aldol reaction of both acyclic and cyclic ketones with different aldehydes in an excess of water/brine. Excellent enantioselectivities up to >99% and diastereoselectivities up to 99% with very good yields were obtained by using much lower catalyst loadings (0.5 mol %).
SN - 1523-7060
UR - https://www.unboundmedicine.com/medline/citation/17518481/Highly_enantioselective_organocatalytic_direct_aldol_reaction_in_an_aqueous_medium_
L2 - https://doi.org/10.1021/ol071013l
DB - PRIME
DP - Unbound Medicine
ER -
