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Randomized double-blind trial of treatment of vitiligo: efficacy of psoralen-UV-A therapy vs Narrowband-UV-B therapy.
Arch Dermatol. 2007 May; 143(5):578-84.AD

Abstract

OBJECTIVE

To compare the efficacy of oral psoralen-UV-A (PUVA) with that of narrowband-UV-B (NB-UVB) phototherapy in patients with nonsegmental vitiligo.

DESIGN

Double-blind randomized study.

SETTING

Phototherapy unit in a university hospital.

PATIENTS

Fifty-six patients with nonsegmental vitiligo. Interventions Twice-weekly therapy with PUVA or NB-UVB.

MAIN OUTCOME MEASURES

The change in body surface area affected by vitiligo and the color match of repigmented skin compared with unaffected skin were assessed after 48 sessions of therapy, at the end of the therapy course, and 12 months after the end of therapy.

RESULTS

The results in the 25 patients each in the PUVA and NB-UVB groups who began therapy were analyzed. The median number of treatments was 47 in the PUVA-treated group and 97 in the NB-UVB-treated group (P = .03); we suspect this difference was because of the differences in efficacy and adverse effects between the 2 modalities, such that patients in the NB-UVB group wanted a longer course of treatment. At the end of therapy, 16 (64%) of 25 patients in the NB-UVB group showed greater than 50% improvement in body surface area affected compared with 9 (36%) of 25 patients in the PUVA group. The color match of the repigmented skin was excellent in all patients in the NB-UVB group but in only 11 (44%) of those in the PUVA group (P<.001). In patients who completed 48 sessions, the improvement in body surface area affected by vitiligo was greater with NB-UVB therapy than with PUVA therapy (P = .007). Twelve months after the cessation of therapy, the superiority of NB-UVB tended to be maintained.

CONCLUSION

In the treatment of nonsegmental vitiligo, NB-UVB therapy is superior to oral PUVA therapy.

Authors+Show Affiliations

Dip Der, FCD, Photobiology Unit, Second Floor, St John's Institute of Dermatology, Division of Genetics and Molecular Medicine, Guys, King's and St Thomas' School of Medicine, King's College, London SE1 7EH, England. yones5@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17519217

Citation

Yones, Sami Sasi, et al. "Randomized Double-blind Trial of Treatment of Vitiligo: Efficacy of psoralen-UV-A Therapy Vs Narrowband-UV-B Therapy." Archives of Dermatology, vol. 143, no. 5, 2007, pp. 578-84.
Yones SS, Palmer RA, Garibaldinos TM, et al. Randomized double-blind trial of treatment of vitiligo: efficacy of psoralen-UV-A therapy vs Narrowband-UV-B therapy. Arch Dermatol. 2007;143(5):578-84.
Yones, S. S., Palmer, R. A., Garibaldinos, T. M., & Hawk, J. L. (2007). Randomized double-blind trial of treatment of vitiligo: efficacy of psoralen-UV-A therapy vs Narrowband-UV-B therapy. Archives of Dermatology, 143(5), 578-84.
Yones SS, et al. Randomized Double-blind Trial of Treatment of Vitiligo: Efficacy of psoralen-UV-A Therapy Vs Narrowband-UV-B Therapy. Arch Dermatol. 2007;143(5):578-84. PubMed PMID: 17519217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomized double-blind trial of treatment of vitiligo: efficacy of psoralen-UV-A therapy vs Narrowband-UV-B therapy. AU - Yones,Sami Sasi, AU - Palmer,Roy A, AU - Garibaldinos,Trish M, AU - Hawk,John L M, PY - 2007/5/24/pubmed PY - 2007/7/31/medline PY - 2007/5/24/entrez SP - 578 EP - 84 JF - Archives of dermatology JO - Arch Dermatol VL - 143 IS - 5 N2 - OBJECTIVE: To compare the efficacy of oral psoralen-UV-A (PUVA) with that of narrowband-UV-B (NB-UVB) phototherapy in patients with nonsegmental vitiligo. DESIGN: Double-blind randomized study. SETTING: Phototherapy unit in a university hospital. PATIENTS: Fifty-six patients with nonsegmental vitiligo. Interventions Twice-weekly therapy with PUVA or NB-UVB. MAIN OUTCOME MEASURES: The change in body surface area affected by vitiligo and the color match of repigmented skin compared with unaffected skin were assessed after 48 sessions of therapy, at the end of the therapy course, and 12 months after the end of therapy. RESULTS: The results in the 25 patients each in the PUVA and NB-UVB groups who began therapy were analyzed. The median number of treatments was 47 in the PUVA-treated group and 97 in the NB-UVB-treated group (P = .03); we suspect this difference was because of the differences in efficacy and adverse effects between the 2 modalities, such that patients in the NB-UVB group wanted a longer course of treatment. At the end of therapy, 16 (64%) of 25 patients in the NB-UVB group showed greater than 50% improvement in body surface area affected compared with 9 (36%) of 25 patients in the PUVA group. The color match of the repigmented skin was excellent in all patients in the NB-UVB group but in only 11 (44%) of those in the PUVA group (P<.001). In patients who completed 48 sessions, the improvement in body surface area affected by vitiligo was greater with NB-UVB therapy than with PUVA therapy (P = .007). Twelve months after the cessation of therapy, the superiority of NB-UVB tended to be maintained. CONCLUSION: In the treatment of nonsegmental vitiligo, NB-UVB therapy is superior to oral PUVA therapy. SN - 0003-987X UR - https://www.unboundmedicine.com/medline/citation/17519217/Randomized_double_blind_trial_of_treatment_of_vitiligo:_efficacy_of_psoralen_UV_A_therapy_vs_Narrowband_UV_B_therapy_ DB - PRIME DP - Unbound Medicine ER -