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Effect of chromium supplementation on glucose metabolism and lipids: a systematic review of randomized controlled trials.
Diabetes Care 2007; 30(8):2154-63DC

Abstract

OBJECTIVE

A systematic review of the effect of chromium supplementation on glucose metabolism and lipid levels.

RESEARCH DESIGN AND METHODS

A literature search was conducted in MEDLINE and the Commonwealth Agricultural Bureau. Eligible studies were English language randomized controlled trials of chromium supplement intake > or = 3 weeks, with > or = 10 participants receiving chromium. All trials with glucose metabolism outcomes and trials of individuals with diabetes or glucose intolerance for lipid outcomes were included. Meta-analyses were performed as appropriate.

RESULTS

Forty-one studies met criteria, almost half of which were of poor quality. Among participants with type 2 diabetes, chromium supplementation improved glycosylated hemoglobin levels by -0.6% (95% CI -0.9 to -0.2) and fasting glucose by -1.0 mmol/l (-1.4 to -0.5) but not lipids. There was no benefit in individuals without diabetes. There were some indications of dose effect and differences among chromium formulations. Larger effects were more commonly observed in poor-quality studies. The evidence was limited by poor study quality, heterogeneity in methodology and results, and a lack of consensus on assessment of chromium status.

CONCLUSIONS

No significant effect of chromium on lipid or glucose metabolism was found in people without diabetes. Chromium supplementation significantly improved glycemia among patients with diabetes. However, future studies that address the limitations in the current evidence are needed before definitive claims can be made about the effect of chromium supplementation.

Authors+Show Affiliations

Institute for Clinical Research and Health Policy Studies, Tufts-New England Medical Center, 750 Washington St., NEMC #63, Boston, MA 02111, USA. ebalk@tufts-nemc.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Review
Systematic Review

Language

eng

PubMed ID

17519436

Citation

Balk, Ethan M., et al. "Effect of Chromium Supplementation On Glucose Metabolism and Lipids: a Systematic Review of Randomized Controlled Trials." Diabetes Care, vol. 30, no. 8, 2007, pp. 2154-63.
Balk EM, Tatsioni A, Lichtenstein AH, et al. Effect of chromium supplementation on glucose metabolism and lipids: a systematic review of randomized controlled trials. Diabetes Care. 2007;30(8):2154-63.
Balk, E. M., Tatsioni, A., Lichtenstein, A. H., Lau, J., & Pittas, A. G. (2007). Effect of chromium supplementation on glucose metabolism and lipids: a systematic review of randomized controlled trials. Diabetes Care, 30(8), pp. 2154-63.
Balk EM, et al. Effect of Chromium Supplementation On Glucose Metabolism and Lipids: a Systematic Review of Randomized Controlled Trials. Diabetes Care. 2007;30(8):2154-63. PubMed PMID: 17519436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of chromium supplementation on glucose metabolism and lipids: a systematic review of randomized controlled trials. AU - Balk,Ethan M, AU - Tatsioni,Athina, AU - Lichtenstein,Alice H, AU - Lau,Joseph, AU - Pittas,Anastassios G, Y1 - 2007/05/22/ PY - 2007/5/24/pubmed PY - 2007/10/5/medline PY - 2007/5/24/entrez SP - 2154 EP - 63 JF - Diabetes care JO - Diabetes Care VL - 30 IS - 8 N2 - OBJECTIVE: A systematic review of the effect of chromium supplementation on glucose metabolism and lipid levels. RESEARCH DESIGN AND METHODS: A literature search was conducted in MEDLINE and the Commonwealth Agricultural Bureau. Eligible studies were English language randomized controlled trials of chromium supplement intake > or = 3 weeks, with > or = 10 participants receiving chromium. All trials with glucose metabolism outcomes and trials of individuals with diabetes or glucose intolerance for lipid outcomes were included. Meta-analyses were performed as appropriate. RESULTS: Forty-one studies met criteria, almost half of which were of poor quality. Among participants with type 2 diabetes, chromium supplementation improved glycosylated hemoglobin levels by -0.6% (95% CI -0.9 to -0.2) and fasting glucose by -1.0 mmol/l (-1.4 to -0.5) but not lipids. There was no benefit in individuals without diabetes. There were some indications of dose effect and differences among chromium formulations. Larger effects were more commonly observed in poor-quality studies. The evidence was limited by poor study quality, heterogeneity in methodology and results, and a lack of consensus on assessment of chromium status. CONCLUSIONS: No significant effect of chromium on lipid or glucose metabolism was found in people without diabetes. Chromium supplementation significantly improved glycemia among patients with diabetes. However, future studies that address the limitations in the current evidence are needed before definitive claims can be made about the effect of chromium supplementation. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/17519436/Effect_of_chromium_supplementation_on_glucose_metabolism_and_lipids:_a_systematic_review_of_randomized_controlled_trials_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=17519436 DB - PRIME DP - Unbound Medicine ER -