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Epidural ondansetron is more effective to prevent postoperative pruritus and nausea than intravenous ondansetron in elective cesarean delivery.
Acta Obstet Gynecol Scand. 2007; 86(6):683-7.AO

Abstract

BACKGROUND

Postoperative pruritus, nausea, and vomiting are common side effects of intrathecal or epidural opioids. Intravenous ondansetron has been used for postoperative emesis. However, there are no reports regarding epidural ondansetron. Two studies were conducted to evaluate the prophylactic effects of epidural ondansetron for opioid-induced pruritus, nausea, and vomiting.

METHODS

Neurotoxic signs were checked after epidural injection of ondansetron in rats. A clinical study was conducted to compare the prophylactic effects of epidural ondansetron with intravenous ondansetron for opioid-induced pruritus, nausea, and vomiting in cesarean delivery.

RESULTS

No neurotoxic evidence was found in rats. The incidence of pruritus and nausea was significantly lower in the epidural ondansetron group than in the intravenous ondansetron group at 24 and 48 h postoperatively.

CONCLUSIONS

Epidural ondansetron is more effective in preventing postoperative pruritus and nausea than intravenous ondansetron.

Authors+Show Affiliations

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17520399

Citation

Han, Dong Woo, et al. "Epidural Ondansetron Is More Effective to Prevent Postoperative Pruritus and Nausea Than Intravenous Ondansetron in Elective Cesarean Delivery." Acta Obstetricia Et Gynecologica Scandinavica, vol. 86, no. 6, 2007, pp. 683-7.
Han DW, Hong SW, Kwon JY, et al. Epidural ondansetron is more effective to prevent postoperative pruritus and nausea than intravenous ondansetron in elective cesarean delivery. Acta Obstet Gynecol Scand. 2007;86(6):683-7.
Han, D. W., Hong, S. W., Kwon, J. Y., Lee, J. W., & Kim, K. J. (2007). Epidural ondansetron is more effective to prevent postoperative pruritus and nausea than intravenous ondansetron in elective cesarean delivery. Acta Obstetricia Et Gynecologica Scandinavica, 86(6), 683-7.
Han DW, et al. Epidural Ondansetron Is More Effective to Prevent Postoperative Pruritus and Nausea Than Intravenous Ondansetron in Elective Cesarean Delivery. Acta Obstet Gynecol Scand. 2007;86(6):683-7. PubMed PMID: 17520399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidural ondansetron is more effective to prevent postoperative pruritus and nausea than intravenous ondansetron in elective cesarean delivery. AU - Han,Dong Woo, AU - Hong,Soon Won, AU - Kwon,Ja-Young, AU - Lee,Jae Woo, AU - Kim,Ki Jun, PY - 2007/5/24/pubmed PY - 2007/9/12/medline PY - 2007/5/24/entrez SP - 683 EP - 7 JF - Acta obstetricia et gynecologica Scandinavica JO - Acta Obstet Gynecol Scand VL - 86 IS - 6 N2 - BACKGROUND: Postoperative pruritus, nausea, and vomiting are common side effects of intrathecal or epidural opioids. Intravenous ondansetron has been used for postoperative emesis. However, there are no reports regarding epidural ondansetron. Two studies were conducted to evaluate the prophylactic effects of epidural ondansetron for opioid-induced pruritus, nausea, and vomiting. METHODS: Neurotoxic signs were checked after epidural injection of ondansetron in rats. A clinical study was conducted to compare the prophylactic effects of epidural ondansetron with intravenous ondansetron for opioid-induced pruritus, nausea, and vomiting in cesarean delivery. RESULTS: No neurotoxic evidence was found in rats. The incidence of pruritus and nausea was significantly lower in the epidural ondansetron group than in the intravenous ondansetron group at 24 and 48 h postoperatively. CONCLUSIONS: Epidural ondansetron is more effective in preventing postoperative pruritus and nausea than intravenous ondansetron. SN - 0001-6349 UR - https://www.unboundmedicine.com/medline/citation/17520399/Epidural_ondansetron_is_more_effective_to_prevent_postoperative_pruritus_and_nausea_than_intravenous_ondansetron_in_elective_cesarean_delivery_ L2 - https://doi.org/10.1080/00016340701302616 DB - PRIME DP - Unbound Medicine ER -