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Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet.
Am J Physiol Renal Physiol. 2007 Aug; 293(2):F521-5.AJ

Abstract

We previously demonstrated that typical American net acid-producing diets predict a low-grade metabolic acidosis of severity proportional to the diet net acid load as indexed by the steady-state renal net acid excretion rate (NAE). We now investigate whether a sodium (Na) chloride (Cl) containing diet likewise associates with a low-grade metabolic acidosis of severity proportional to the sodium chloride content of the diet as indexed by the steady-state Na and Cl excretion rates. In the steady-state preintervention periods of our previously reported studies comprising 77 healthy subjects, we averaged in each subject three to six values of blood hydrogen ion concentration ([H]b), plasma bicarbonate concentration ([HCO(3)(-)]p), the partial pressure of carbon dioxide (Pco(2)), the urinary excretion rates of Na, Cl, NAE, and renal function as measured by creatinine clearance (CrCl), and performed multivariate analyses. Dietary Cl strongly correlated positively with dietary Na (P < 0.001) and was an independent negative predictor of [HCO(3)(-)]p after adjustment for diet net acid load, Pco(2) and CrCl, and positive and negative predictors, respectively, of [H]b and [HCO(3)(-)]p after adjustment for diet acid load and Pco(2). These data provide the first evidence that, in healthy humans, the diet loads of NaCl and net acid independently predict systemic acid-base status, with increasing degrees of low-grade hyperchloremic metabolic acidosis as the loads increase. Assuming a causal relationship, over their respective ranges of variation, NaCl has approximately 50-100% of the acidosis-producing effect of the diet net acid load.

Authors+Show Affiliations

Dept. of Medicine and General Clinical Research Center, University of California, San Francisco, CA 94143, USA. frassett@gcrc.ucsf.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17522265

Citation

Frassetto, Lynda A., et al. "Dietary Sodium Chloride Intake Independently Predicts the Degree of Hyperchloremic Metabolic Acidosis in Healthy Humans Consuming a Net Acid-producing Diet." American Journal of Physiology. Renal Physiology, vol. 293, no. 2, 2007, pp. F521-5.
Frassetto LA, Morris RC, Sebastian A. Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet. Am J Physiol Renal Physiol. 2007;293(2):F521-5.
Frassetto, L. A., Morris, R. C., & Sebastian, A. (2007). Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet. American Journal of Physiology. Renal Physiology, 293(2), F521-5.
Frassetto LA, Morris RC, Sebastian A. Dietary Sodium Chloride Intake Independently Predicts the Degree of Hyperchloremic Metabolic Acidosis in Healthy Humans Consuming a Net Acid-producing Diet. Am J Physiol Renal Physiol. 2007;293(2):F521-5. PubMed PMID: 17522265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet. AU - Frassetto,Lynda A, AU - Morris,R Curtis,Jr AU - Sebastian,Anthony, Y1 - 2007/05/23/ PY - 2007/5/25/pubmed PY - 2007/9/27/medline PY - 2007/5/25/entrez SP - F521 EP - 5 JF - American journal of physiology. Renal physiology JO - Am J Physiol Renal Physiol VL - 293 IS - 2 N2 - We previously demonstrated that typical American net acid-producing diets predict a low-grade metabolic acidosis of severity proportional to the diet net acid load as indexed by the steady-state renal net acid excretion rate (NAE). We now investigate whether a sodium (Na) chloride (Cl) containing diet likewise associates with a low-grade metabolic acidosis of severity proportional to the sodium chloride content of the diet as indexed by the steady-state Na and Cl excretion rates. In the steady-state preintervention periods of our previously reported studies comprising 77 healthy subjects, we averaged in each subject three to six values of blood hydrogen ion concentration ([H]b), plasma bicarbonate concentration ([HCO(3)(-)]p), the partial pressure of carbon dioxide (Pco(2)), the urinary excretion rates of Na, Cl, NAE, and renal function as measured by creatinine clearance (CrCl), and performed multivariate analyses. Dietary Cl strongly correlated positively with dietary Na (P < 0.001) and was an independent negative predictor of [HCO(3)(-)]p after adjustment for diet net acid load, Pco(2) and CrCl, and positive and negative predictors, respectively, of [H]b and [HCO(3)(-)]p after adjustment for diet acid load and Pco(2). These data provide the first evidence that, in healthy humans, the diet loads of NaCl and net acid independently predict systemic acid-base status, with increasing degrees of low-grade hyperchloremic metabolic acidosis as the loads increase. Assuming a causal relationship, over their respective ranges of variation, NaCl has approximately 50-100% of the acidosis-producing effect of the diet net acid load. SN - 1931-857X UR - https://www.unboundmedicine.com/medline/citation/17522265/Dietary_sodium_chloride_intake_independently_predicts_the_degree_of_hyperchloremic_metabolic_acidosis_in_healthy_humans_consuming_a_net_acid_producing_diet_ L2 - https://journals.physiology.org/doi/10.1152/ajprenal.00048.2007?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -