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The efficacy of micronutrient supplementation in reducing the prevalence of anaemia and deficiencies of zinc and iron among adolescents in Sri Lanka.
Eur J Clin Nutr. 2008 Jul; 62(7):856-65.EJ

Abstract

OBJECTIVE

To determine the effectiveness of combined iron and zinc over the iron or zinc-only supplementation in correcting deficiency and possible interactive effects in a group of adolescent school children.

SUBJECTS AND METHODS

Schoolchildren (n=821) of 12-16 years of age were randomized into four groups and supplemented with iron (50 mg/day), zinc (14 mg/day), iron+zinc or placebo capsules 5 days per week for 24 weeks. Anthropometry, and haemoglobin (Hb), serum zinc (SZn) and serum ferritin (SF) concentrations were determined before and after the intervention.

RESULTS

There were no significant effects between-groups in their weight, height and Hb concentrations with the intervention when compared with the placebo group. Iron-only and combination-supplemented groups had reached mean SF concentrations of 55.1 microg/l with no difference between them (P=0.99). The zinc-only group had a mean change of 4.3 micromol//l whereas the combine-supplemented group had a mean change of 4.0 micromol/l (P=0.82). The prevalence of anaemia was found to be 70.3% in the iron group at baseline; this was reduced to 14.5% after the supplementation. In the combine-supplemented group anaemia, prevalence was reduced from 64.8 to 19.3%.

CONCLUSIONS

Zinc alone or in combination with iron has not shown a significant improvement in growth in adolescence. Severe and moderate forms of anaemia were successfully treated in children who received iron supplementation. Initial high prevalence of low SZn and iron stores was significantly improved with micronutrient supplementation.

Authors+Show Affiliations

Nuclear Medicine Unit, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka. nmu_galle@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17522609

Citation

Hettiarachchi, M, et al. "The Efficacy of Micronutrient Supplementation in Reducing the Prevalence of Anaemia and Deficiencies of Zinc and Iron Among Adolescents in Sri Lanka." European Journal of Clinical Nutrition, vol. 62, no. 7, 2008, pp. 856-65.
Hettiarachchi M, Liyanage C, Wickremasinghe R, et al. The efficacy of micronutrient supplementation in reducing the prevalence of anaemia and deficiencies of zinc and iron among adolescents in Sri Lanka. Eur J Clin Nutr. 2008;62(7):856-65.
Hettiarachchi, M., Liyanage, C., Wickremasinghe, R., Hilmers, D. C., & Abrams, S. A. (2008). The efficacy of micronutrient supplementation in reducing the prevalence of anaemia and deficiencies of zinc and iron among adolescents in Sri Lanka. European Journal of Clinical Nutrition, 62(7), 856-65.
Hettiarachchi M, et al. The Efficacy of Micronutrient Supplementation in Reducing the Prevalence of Anaemia and Deficiencies of Zinc and Iron Among Adolescents in Sri Lanka. Eur J Clin Nutr. 2008;62(7):856-65. PubMed PMID: 17522609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The efficacy of micronutrient supplementation in reducing the prevalence of anaemia and deficiencies of zinc and iron among adolescents in Sri Lanka. AU - Hettiarachchi,M, AU - Liyanage,C, AU - Wickremasinghe,R, AU - Hilmers,D C, AU - Abrams,S A, Y1 - 2007/05/16/ PY - 2007/5/25/pubmed PY - 2008/12/17/medline PY - 2007/5/25/entrez SP - 856 EP - 65 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 62 IS - 7 N2 - OBJECTIVE: To determine the effectiveness of combined iron and zinc over the iron or zinc-only supplementation in correcting deficiency and possible interactive effects in a group of adolescent school children. SUBJECTS AND METHODS: Schoolchildren (n=821) of 12-16 years of age were randomized into four groups and supplemented with iron (50 mg/day), zinc (14 mg/day), iron+zinc or placebo capsules 5 days per week for 24 weeks. Anthropometry, and haemoglobin (Hb), serum zinc (SZn) and serum ferritin (SF) concentrations were determined before and after the intervention. RESULTS: There were no significant effects between-groups in their weight, height and Hb concentrations with the intervention when compared with the placebo group. Iron-only and combination-supplemented groups had reached mean SF concentrations of 55.1 microg/l with no difference between them (P=0.99). The zinc-only group had a mean change of 4.3 micromol//l whereas the combine-supplemented group had a mean change of 4.0 micromol/l (P=0.82). The prevalence of anaemia was found to be 70.3% in the iron group at baseline; this was reduced to 14.5% after the supplementation. In the combine-supplemented group anaemia, prevalence was reduced from 64.8 to 19.3%. CONCLUSIONS: Zinc alone or in combination with iron has not shown a significant improvement in growth in adolescence. Severe and moderate forms of anaemia were successfully treated in children who received iron supplementation. Initial high prevalence of low SZn and iron stores was significantly improved with micronutrient supplementation. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17522609/The_efficacy_of_micronutrient_supplementation_in_reducing_the_prevalence_of_anaemia_and_deficiencies_of_zinc_and_iron_among_adolescents_in_Sri_Lanka_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602791 DB - PRIME DP - Unbound Medicine ER -