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Prospective study of coffee consumption and risk of Parkinson's disease.
Eur J Clin Nutr. 2008 Jul; 62(7):908-15.EJ

Abstract

OBJECTIVE

To examine the prediction of coffee consumption on the incidence of Parkinson's disease.

SUBJECTS AND METHODS

The study population comprised 6710 men and women, aged 50-79 years and free from Parkinson's disease at the baseline. At baseline, enquiries were made about coffee consumption in a self-administered questionnaire as the average number of cups per day. During a 22-year follow-up, 101 incident cases of Parkinson's disease occurred. Parkinson's disease cases were identified through a nationwide registry of patients receiving medication reimbursement, which is based on certificates from neurologist.

RESULTS

After adjustments for age, sex, marital status, education, community density, alcohol consumption, leisure-time physical activity, smoking, body mass index, hypertension and serum cholesterol, the relative risk for subjects drinking 10 or more cups of coffee per day compared with non-drinkers was 0.26 (95% confidence interval 0.07-0.99, P-value for trend=0.18). The association was stronger among overweight persons and among persons with lower serum cholesterol level (P-value for interaction=0.04 and 0.03, respectively).

CONCLUSIONS

The results support the hypothesis that coffee consumption reduces the risk of Parkinson's disease, but protective effect of coffee may vary by exposure to other factors.

Authors+Show Affiliations

National Public Health Institute, Mannerheimintie 166, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17522612

Citation

Sääksjärvi, K, et al. "Prospective Study of Coffee Consumption and Risk of Parkinson's Disease." European Journal of Clinical Nutrition, vol. 62, no. 7, 2008, pp. 908-15.
Sääksjärvi K, Knekt P, Rissanen H, et al. Prospective study of coffee consumption and risk of Parkinson's disease. Eur J Clin Nutr. 2008;62(7):908-15.
Sääksjärvi, K., Knekt, P., Rissanen, H., Laaksonen, M. A., Reunanen, A., & Männistö, S. (2008). Prospective study of coffee consumption and risk of Parkinson's disease. European Journal of Clinical Nutrition, 62(7), 908-15.
Sääksjärvi K, et al. Prospective Study of Coffee Consumption and Risk of Parkinson's Disease. Eur J Clin Nutr. 2008;62(7):908-15. PubMed PMID: 17522612.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective study of coffee consumption and risk of Parkinson's disease. AU - Sääksjärvi,K, AU - Knekt,P, AU - Rissanen,H, AU - Laaksonen,M A, AU - Reunanen,A, AU - Männistö,S, Y1 - 2007/05/16/ PY - 2007/5/25/pubmed PY - 2008/12/17/medline PY - 2007/5/25/entrez SP - 908 EP - 15 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 62 IS - 7 N2 - OBJECTIVE: To examine the prediction of coffee consumption on the incidence of Parkinson's disease. SUBJECTS AND METHODS: The study population comprised 6710 men and women, aged 50-79 years and free from Parkinson's disease at the baseline. At baseline, enquiries were made about coffee consumption in a self-administered questionnaire as the average number of cups per day. During a 22-year follow-up, 101 incident cases of Parkinson's disease occurred. Parkinson's disease cases were identified through a nationwide registry of patients receiving medication reimbursement, which is based on certificates from neurologist. RESULTS: After adjustments for age, sex, marital status, education, community density, alcohol consumption, leisure-time physical activity, smoking, body mass index, hypertension and serum cholesterol, the relative risk for subjects drinking 10 or more cups of coffee per day compared with non-drinkers was 0.26 (95% confidence interval 0.07-0.99, P-value for trend=0.18). The association was stronger among overweight persons and among persons with lower serum cholesterol level (P-value for interaction=0.04 and 0.03, respectively). CONCLUSIONS: The results support the hypothesis that coffee consumption reduces the risk of Parkinson's disease, but protective effect of coffee may vary by exposure to other factors. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17522612/Prospective_study_of_coffee_consumption_and_risk_of_Parkinson's_disease_ L2 - https://doi.org/10.1038/sj.ejcn.1602788 DB - PRIME DP - Unbound Medicine ER -