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Effect of fasting on young adults who have symptoms of hypoglycemia in the absence of frequent meals.

Abstract

BACKGROUND AND OBJECTIVES

Among otherwise healthy adults, there is a subgroup of individuals who develop symptoms of hypoglycemia during episodes of food restriction. The aim of the present study was to investigate whether such individuals develop hypoglycemia or react abnormally in other metabolic aspects during a 24-hour fast.

SUBJECTS AND METHODS

Ninety medical students were asked if they wanted to participate. Sixteen were selected; none dropped out. A 24-hour fast was performed at a hospital ward. Blood samples and questionnaires were taken at eight specific times.

RESULT

During the fast, the sensitive group reported significantly higher scores on 'irritation' and 'shakiness'. However, no hypoglycemia occurred and the lowest detected blood glucose concentration was 3.7 mmol/l. There were no differences between the groups in plasma glucose, cortisol, growth hormone (GH), insulin, beta-hydroxybutyrate (beta-OH) and lactate levels. The blood pressures and heart rates were also similar.

CONCLUSIONS

Adults, despite subjective signs of hypoglycemia, can fast without any metabolic or endocrine derangement.

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    MeSH

    Adult
    Analysis of Variance
    Area Under Curve
    Blood Glucose
    Case-Control Studies
    Fasting
    Female
    Humans
    Hypoglycemia
    Insulin
    Male
    Time Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17522614

    Citation

    TY - JOUR T1 - Effect of fasting on young adults who have symptoms of hypoglycemia in the absence of frequent meals. AU - Alkén,J, AU - Petriczko,E, AU - Marcus,C, Y1 - 2007/05/16/ PY - 2007/5/16/aheadofprint PY - 2007/5/25/pubmed PY - 2008/10/24/medline PY - 2007/5/25/entrez SP - 721 EP - 6 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 62 IS - 6 N2 - BACKGROUND AND OBJECTIVES: Among otherwise healthy adults, there is a subgroup of individuals who develop symptoms of hypoglycemia during episodes of food restriction. The aim of the present study was to investigate whether such individuals develop hypoglycemia or react abnormally in other metabolic aspects during a 24-hour fast. SUBJECTS AND METHODS: Ninety medical students were asked if they wanted to participate. Sixteen were selected; none dropped out. A 24-hour fast was performed at a hospital ward. Blood samples and questionnaires were taken at eight specific times. RESULT: During the fast, the sensitive group reported significantly higher scores on 'irritation' and 'shakiness'. However, no hypoglycemia occurred and the lowest detected blood glucose concentration was 3.7 mmol/l. There were no differences between the groups in plasma glucose, cortisol, growth hormone (GH), insulin, beta-hydroxybutyrate (beta-OH) and lactate levels. The blood pressures and heart rates were also similar. CONCLUSIONS: Adults, despite subjective signs of hypoglycemia, can fast without any metabolic or endocrine derangement. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17522614/Effect_of_fasting_on_young_adults_who_have_symptoms_of_hypoglycemia_in_the_absence_of_frequent_meals_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602785 ER -