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Effect of fasting on young adults who have symptoms of hypoglycemia in the absence of frequent meals.
Eur J Clin Nutr 2008; 62(6):721-6EJ

Abstract

BACKGROUND AND OBJECTIVES

Among otherwise healthy adults, there is a subgroup of individuals who develop symptoms of hypoglycemia during episodes of food restriction. The aim of the present study was to investigate whether such individuals develop hypoglycemia or react abnormally in other metabolic aspects during a 24-hour fast.

SUBJECTS AND METHODS

Ninety medical students were asked if they wanted to participate. Sixteen were selected; none dropped out. A 24-hour fast was performed at a hospital ward. Blood samples and questionnaires were taken at eight specific times.

RESULT

During the fast, the sensitive group reported significantly higher scores on 'irritation' and 'shakiness'. However, no hypoglycemia occurred and the lowest detected blood glucose concentration was 3.7 mmol/l. There were no differences between the groups in plasma glucose, cortisol, growth hormone (GH), insulin, beta-hydroxybutyrate (beta-OH) and lactate levels. The blood pressures and heart rates were also similar.

CONCLUSIONS

Adults, despite subjective signs of hypoglycemia, can fast without any metabolic or endocrine derangement.

Authors+Show Affiliations

Department for Clinical Science, Intervention and Technology, Karolinska Institutet, Huddinge, Department of Pediatrics, Karolinska University Hospital, Stockholm, Sweden. jenny.alken@ki.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17522614

Citation

Alkén, J, et al. "Effect of Fasting On Young Adults Who Have Symptoms of Hypoglycemia in the Absence of Frequent Meals." European Journal of Clinical Nutrition, vol. 62, no. 6, 2008, pp. 721-6.
Alkén J, Petriczko E, Marcus C. Effect of fasting on young adults who have symptoms of hypoglycemia in the absence of frequent meals. Eur J Clin Nutr. 2008;62(6):721-6.
Alkén, J., Petriczko, E., & Marcus, C. (2008). Effect of fasting on young adults who have symptoms of hypoglycemia in the absence of frequent meals. European Journal of Clinical Nutrition, 62(6), pp. 721-6.
Alkén J, Petriczko E, Marcus C. Effect of Fasting On Young Adults Who Have Symptoms of Hypoglycemia in the Absence of Frequent Meals. Eur J Clin Nutr. 2008;62(6):721-6. PubMed PMID: 17522614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of fasting on young adults who have symptoms of hypoglycemia in the absence of frequent meals. AU - Alkén,J, AU - Petriczko,E, AU - Marcus,C, Y1 - 2007/05/16/ PY - 2007/5/25/pubmed PY - 2008/10/24/medline PY - 2007/5/25/entrez SP - 721 EP - 6 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 62 IS - 6 N2 - BACKGROUND AND OBJECTIVES: Among otherwise healthy adults, there is a subgroup of individuals who develop symptoms of hypoglycemia during episodes of food restriction. The aim of the present study was to investigate whether such individuals develop hypoglycemia or react abnormally in other metabolic aspects during a 24-hour fast. SUBJECTS AND METHODS: Ninety medical students were asked if they wanted to participate. Sixteen were selected; none dropped out. A 24-hour fast was performed at a hospital ward. Blood samples and questionnaires were taken at eight specific times. RESULT: During the fast, the sensitive group reported significantly higher scores on 'irritation' and 'shakiness'. However, no hypoglycemia occurred and the lowest detected blood glucose concentration was 3.7 mmol/l. There were no differences between the groups in plasma glucose, cortisol, growth hormone (GH), insulin, beta-hydroxybutyrate (beta-OH) and lactate levels. The blood pressures and heart rates were also similar. CONCLUSIONS: Adults, despite subjective signs of hypoglycemia, can fast without any metabolic or endocrine derangement. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17522614/Effect_of_fasting_on_young_adults_who_have_symptoms_of_hypoglycemia_in_the_absence_of_frequent_meals_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602785 DB - PRIME DP - Unbound Medicine ER -