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Kinetics of aqueous flare, intraocular pressure and virus-DNA copies in a patient with cytomegalovirus iridocyclitis without retinitis.
Int Ophthalmol. 2007 Dec; 27(6):383-6.IO

Abstract

BACKGROUND

A case report of recurrent unilateral granulomatous iridocyclitis with ocular hypertension without retinitis caused by cytomegalovirus (CMV) in an immunocompetent patient.

METHODS

Aqueous humor was analysed by multiplex PCR to detect viral DNA, and real-time PCR was used to evaluate virus copies before and after anti-virus treatments. Inflammation of the anterior chamber was evaluated by a laser flare photometry.

RESULTS

Genomic DNA of CMV - but not of other herpes viruses - was detected in the aqueous humor. Quantitative real-time PCR revealed 2.3 x 10(5) copies/ml of CMV DNA from the specimen. Oral valganciclovir was added to the ongoing treatment, which consisted of topical corticosteroid, timolol and latanoprost as well as systemic acetazolamide, resulting in the reduction of aqueous flare correlated with the reduction of virus copies in aqueous humor.

CONCLUSIONS

In this case of CMV-related iridocyclitis in an immunocompetent patient, specific additional anti-viral therapy was effective in controlling inflammation of anterior chamber but, as is so often the case, it was unable to control intraocular pressure. We show that inflammatory activity correlated well with the number of virus copies in the aqueous humor.

Authors+Show Affiliations

Department of Ophthalmology & Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan. kouseidon2002@yahoo.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17522780

Citation

Kawaguchi, Tatsushi, et al. "Kinetics of Aqueous Flare, Intraocular Pressure and virus-DNA Copies in a Patient With Cytomegalovirus Iridocyclitis Without Retinitis." International Ophthalmology, vol. 27, no. 6, 2007, pp. 383-6.
Kawaguchi T, Sugita S, Shimizu N, et al. Kinetics of aqueous flare, intraocular pressure and virus-DNA copies in a patient with cytomegalovirus iridocyclitis without retinitis. Int Ophthalmol. 2007;27(6):383-6.
Kawaguchi, T., Sugita, S., Shimizu, N., & Mochizuki, M. (2007). Kinetics of aqueous flare, intraocular pressure and virus-DNA copies in a patient with cytomegalovirus iridocyclitis without retinitis. International Ophthalmology, 27(6), 383-6.
Kawaguchi T, et al. Kinetics of Aqueous Flare, Intraocular Pressure and virus-DNA Copies in a Patient With Cytomegalovirus Iridocyclitis Without Retinitis. Int Ophthalmol. 2007;27(6):383-6. PubMed PMID: 17522780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kinetics of aqueous flare, intraocular pressure and virus-DNA copies in a patient with cytomegalovirus iridocyclitis without retinitis. AU - Kawaguchi,Tatsushi, AU - Sugita,Sunao, AU - Shimizu,Norio, AU - Mochizuki,Manabu, Y1 - 2007/05/24/ PY - 2006/12/04/received PY - 2007/04/12/accepted PY - 2007/5/25/pubmed PY - 2008/1/16/medline PY - 2007/5/25/entrez SP - 383 EP - 6 JF - International ophthalmology JO - Int Ophthalmol VL - 27 IS - 6 N2 - BACKGROUND: A case report of recurrent unilateral granulomatous iridocyclitis with ocular hypertension without retinitis caused by cytomegalovirus (CMV) in an immunocompetent patient. METHODS: Aqueous humor was analysed by multiplex PCR to detect viral DNA, and real-time PCR was used to evaluate virus copies before and after anti-virus treatments. Inflammation of the anterior chamber was evaluated by a laser flare photometry. RESULTS: Genomic DNA of CMV - but not of other herpes viruses - was detected in the aqueous humor. Quantitative real-time PCR revealed 2.3 x 10(5) copies/ml of CMV DNA from the specimen. Oral valganciclovir was added to the ongoing treatment, which consisted of topical corticosteroid, timolol and latanoprost as well as systemic acetazolamide, resulting in the reduction of aqueous flare correlated with the reduction of virus copies in aqueous humor. CONCLUSIONS: In this case of CMV-related iridocyclitis in an immunocompetent patient, specific additional anti-viral therapy was effective in controlling inflammation of anterior chamber but, as is so often the case, it was unable to control intraocular pressure. We show that inflammatory activity correlated well with the number of virus copies in the aqueous humor. SN - 0165-5701 UR - https://www.unboundmedicine.com/medline/citation/17522780/Kinetics_of_aqueous_flare_intraocular_pressure_and_virus_DNA_copies_in_a_patient_with_cytomegalovirus_iridocyclitis_without_retinitis_ L2 - https://doi.org/10.1007/s10792-007-9090-5 DB - PRIME DP - Unbound Medicine ER -