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Bowel movement frequency in late-life and incidental Lewy bodies.
Mov Disord. 2007 Aug 15; 22(11):1581-6.MD

Abstract

It is not known if constipation is associated with the preclinical phase of Parkinson's disease (PD), often characterized by the presence of incidental Lewy bodies (ILB). Such an association could provide evidence that constipation is an early symptom of PD. The purpose of this report is to examine the association between late-life bowel movement frequency and ILB. Bowel movement frequency was assessed from 1991 to 1993 in 245 men aged 71 to 93 years in the Honolulu-Asia Aging Study who later received postmortem examinations. All were without clinical PD and dementia. Brains were examined for ILB in the substantia nigra and locus ceruleus. Among the decedents, 30 men had ILB (12.2%). After age-adjustment, the percent of brains with ILB declined with increasing bowel movement frequency (P=0.013). For men with <1, 1, and >1 bowel movement/day, corresponding percents were 24.1, 13.5, and 6.5%. Findings persisted after additional adjustment for time to death, mid-life pack-years of smoking and coffee intake, physical activity, and cognitive function. Infrequent bowel movements are associated with ILB. Findings provide evidence that constipation can predate the extrapyramidal signs of PD. Constipation could be one of the earliest markers of the beginning of PD processes.

Authors+Show Affiliations

Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908-0717, and Veterans Affairs Pacific Islands Health Care System, Honolulu, HI, USA. rda3e@virginia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17523195

Citation

Abbott, Robert D., et al. "Bowel Movement Frequency in Late-life and Incidental Lewy Bodies." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 22, no. 11, 2007, pp. 1581-6.
Abbott RD, Ross GW, Petrovitch H, et al. Bowel movement frequency in late-life and incidental Lewy bodies. Mov Disord. 2007;22(11):1581-6.
Abbott, R. D., Ross, G. W., Petrovitch, H., Tanner, C. M., Davis, D. G., Masaki, K. H., Launer, L. J., Curb, J. D., & White, L. R. (2007). Bowel movement frequency in late-life and incidental Lewy bodies. Movement Disorders : Official Journal of the Movement Disorder Society, 22(11), 1581-6.
Abbott RD, et al. Bowel Movement Frequency in Late-life and Incidental Lewy Bodies. Mov Disord. 2007 Aug 15;22(11):1581-6. PubMed PMID: 17523195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bowel movement frequency in late-life and incidental Lewy bodies. AU - Abbott,Robert D, AU - Ross,G Webster, AU - Petrovitch,Helen, AU - Tanner,Caroline M, AU - Davis,Daron G, AU - Masaki,Kamal H, AU - Launer,Lenore J, AU - Curb,J David, AU - White,Lon R, PY - 2007/5/25/pubmed PY - 2007/12/6/medline PY - 2007/5/25/entrez SP - 1581 EP - 6 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 22 IS - 11 N2 - It is not known if constipation is associated with the preclinical phase of Parkinson's disease (PD), often characterized by the presence of incidental Lewy bodies (ILB). Such an association could provide evidence that constipation is an early symptom of PD. The purpose of this report is to examine the association between late-life bowel movement frequency and ILB. Bowel movement frequency was assessed from 1991 to 1993 in 245 men aged 71 to 93 years in the Honolulu-Asia Aging Study who later received postmortem examinations. All were without clinical PD and dementia. Brains were examined for ILB in the substantia nigra and locus ceruleus. Among the decedents, 30 men had ILB (12.2%). After age-adjustment, the percent of brains with ILB declined with increasing bowel movement frequency (P=0.013). For men with <1, 1, and >1 bowel movement/day, corresponding percents were 24.1, 13.5, and 6.5%. Findings persisted after additional adjustment for time to death, mid-life pack-years of smoking and coffee intake, physical activity, and cognitive function. Infrequent bowel movements are associated with ILB. Findings provide evidence that constipation can predate the extrapyramidal signs of PD. Constipation could be one of the earliest markers of the beginning of PD processes. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/17523195/Bowel_movement_frequency_in_late_life_and_incidental_Lewy_bodies_ L2 - https://doi.org/10.1002/mds.21560 DB - PRIME DP - Unbound Medicine ER -