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Huge pseudocyst of the pancreas caused by poorly differentiated invasive ductal adenocarcinoma with osteoclast-like giant cells: report of a case.
Hepatogastroenterology. 2007 Mar; 54(74):599-601.H

Abstract

A 72-year-old man presented with several week's abdominal distension and jaundice. Under the tentative diagnosis of pancreatic pseudocyst of 22cm in diameter, a percutaneous drainage was performed. Despite the reduction of the pseudocyst, his serum total bilirubin level was increased. At this time, abdominal computed tomography scan showed a tumor at the uncinate process of the pancreas. After the biliary decompression, a total pancreatectomy with the resection of pseudocyst walls and splenectomy was performed. It was histologically proven to be poorly differentiated ductal adenocarcinoma in combination with osteoclast-like giant cells. The pseudocyst was considered to be due to the stenosis of the main pancreatic duct caused by carcinoma of the uncinate process. Five months later, he died of recurrent carcinomatous peritonitis. Osteoclast-like giant cell tumor is a very rare neoplasm, the origin and prognosis of which still remain obscure. However, it has to be considered in the differential diagnosis of cystic changes of the pancreas, especially of pseudocyst. Furthermore, detailed surveys are needed in cases of pseudocyst of the pancreas without chronic pancreatitis, in order to identify small carcinoma of the pancreas.

Authors+Show Affiliations

Department of Surgery, Rakuwakai-Otowa Hospital, Kyoto, Japan. rakuwadr001@rakuwadr.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

17523330

Citation

Yamaguchi, Tetsuya, et al. "Huge Pseudocyst of the Pancreas Caused By Poorly Differentiated Invasive Ductal Adenocarcinoma With Osteoclast-like Giant Cells: Report of a Case." Hepato-gastroenterology, vol. 54, no. 74, 2007, pp. 599-601.
Yamaguchi T, Takahashi H, Kagawa R, et al. Huge pseudocyst of the pancreas caused by poorly differentiated invasive ductal adenocarcinoma with osteoclast-like giant cells: report of a case. Hepatogastroenterology. 2007;54(74):599-601.
Yamaguchi, T., Takahashi, H., Kagawa, R., Takeda, R., Sakata, S., Yamamoto, M., & Nishizaki, D. (2007). Huge pseudocyst of the pancreas caused by poorly differentiated invasive ductal adenocarcinoma with osteoclast-like giant cells: report of a case. Hepato-gastroenterology, 54(74), 599-601.
Yamaguchi T, et al. Huge Pseudocyst of the Pancreas Caused By Poorly Differentiated Invasive Ductal Adenocarcinoma With Osteoclast-like Giant Cells: Report of a Case. Hepatogastroenterology. 2007;54(74):599-601. PubMed PMID: 17523330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Huge pseudocyst of the pancreas caused by poorly differentiated invasive ductal adenocarcinoma with osteoclast-like giant cells: report of a case. AU - Yamaguchi,Tetsuya, AU - Takahashi,Hiroshi, AU - Kagawa,Ryuzaburo, AU - Takeda,Ryoji, AU - Sakata,Shingo, AU - Yamamoto,Michihiro, AU - Nishizaki,Daisuke, PY - 2007/5/26/pubmed PY - 2007/8/2/medline PY - 2007/5/26/entrez SP - 599 EP - 601 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 54 IS - 74 N2 - A 72-year-old man presented with several week's abdominal distension and jaundice. Under the tentative diagnosis of pancreatic pseudocyst of 22cm in diameter, a percutaneous drainage was performed. Despite the reduction of the pseudocyst, his serum total bilirubin level was increased. At this time, abdominal computed tomography scan showed a tumor at the uncinate process of the pancreas. After the biliary decompression, a total pancreatectomy with the resection of pseudocyst walls and splenectomy was performed. It was histologically proven to be poorly differentiated ductal adenocarcinoma in combination with osteoclast-like giant cells. The pseudocyst was considered to be due to the stenosis of the main pancreatic duct caused by carcinoma of the uncinate process. Five months later, he died of recurrent carcinomatous peritonitis. Osteoclast-like giant cell tumor is a very rare neoplasm, the origin and prognosis of which still remain obscure. However, it has to be considered in the differential diagnosis of cystic changes of the pancreas, especially of pseudocyst. Furthermore, detailed surveys are needed in cases of pseudocyst of the pancreas without chronic pancreatitis, in order to identify small carcinoma of the pancreas. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/17523330/Huge_pseudocyst_of_the_pancreas_caused_by_poorly_differentiated_invasive_ductal_adenocarcinoma_with_osteoclast_like_giant_cells:_report_of_a_case_ L2 - https://medlineplus.gov/pancreaticcancer.html DB - PRIME DP - Unbound Medicine ER -