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The effects of delta9-tetrahydrocannabinol and cannabidiol on the metabolism of gonadal steroids in the rat.
Drug Metab Dispos. 1977 May-Jun; 5(3):268-72.DM

Abstract

The effects of delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on hydroxylation of estradiol and testosterone in rat liver microsomes were investigated. Acute and chronic treatment of male and female rats with either cannabinoid, 2 or 10 mg/kg, significantly elevated steroid hydroxylase activity. Acute administration of THC or CBD, 10 mg/kg, evoked no detectable changes in cytochrome P-450 levels, but a significant decrease in those of cytochrome b5. Chronic administration of THC or CBD, 2 mg/kg, decreased levels of cytochrome P-450, whereas cytochrome b5 levels appeared normal. Acute doses of THC or CBD at 10 mg/kg significantly depressed testosterone formation in testis microsomes. Chronic THC, 2 mg/kg, but not CBD, evoked the most dramatic decrease in testicular enzyme activity.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17525

Citation

List, A, et al. "The Effects of Delta9-tetrahydrocannabinol and Cannabidiol On the Metabolism of Gonadal Steroids in the Rat." Drug Metabolism and Disposition: the Biological Fate of Chemicals, vol. 5, no. 3, 1977, pp. 268-72.
List A, Nazar B, Nyquist S, et al. The effects of delta9-tetrahydrocannabinol and cannabidiol on the metabolism of gonadal steroids in the rat. Drug Metab Dispos. 1977;5(3):268-72.
List, A., Nazar, B., Nyquist, S., & Harclerode, J. (1977). The effects of delta9-tetrahydrocannabinol and cannabidiol on the metabolism of gonadal steroids in the rat. Drug Metabolism and Disposition: the Biological Fate of Chemicals, 5(3), 268-72.
List A, et al. The Effects of Delta9-tetrahydrocannabinol and Cannabidiol On the Metabolism of Gonadal Steroids in the Rat. Drug Metab Dispos. 1977 May-Jun;5(3):268-72. PubMed PMID: 17525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of delta9-tetrahydrocannabinol and cannabidiol on the metabolism of gonadal steroids in the rat. AU - List,A, AU - Nazar,B, AU - Nyquist,S, AU - Harclerode,J, PY - 1977/5/1/pubmed PY - 1977/5/1/medline PY - 1977/5/1/entrez SP - 268 EP - 72 JF - Drug metabolism and disposition: the biological fate of chemicals JO - Drug Metab Dispos VL - 5 IS - 3 N2 - The effects of delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on hydroxylation of estradiol and testosterone in rat liver microsomes were investigated. Acute and chronic treatment of male and female rats with either cannabinoid, 2 or 10 mg/kg, significantly elevated steroid hydroxylase activity. Acute administration of THC or CBD, 10 mg/kg, evoked no detectable changes in cytochrome P-450 levels, but a significant decrease in those of cytochrome b5. Chronic administration of THC or CBD, 2 mg/kg, decreased levels of cytochrome P-450, whereas cytochrome b5 levels appeared normal. Acute doses of THC or CBD at 10 mg/kg significantly depressed testosterone formation in testis microsomes. Chronic THC, 2 mg/kg, but not CBD, evoked the most dramatic decrease in testicular enzyme activity. SN - 0090-9556 UR - https://www.unboundmedicine.com/medline/citation/17525/The_effects_of_delta9_tetrahydrocannabinol_and_cannabidiol_on_the_metabolism_of_gonadal_steroids_in_the_rat_ L2 - http://dmd.aspetjournals.org/cgi/pmidlookup?view=long&pmid=17525 DB - PRIME DP - Unbound Medicine ER -