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Association of single nucleotide polymorphisms in endothelin family genes with the progression of atherosclerosis in patients with essential hypertension.
J Hum Hypertens. 2007 Nov; 21(11):883-92.JH

Abstract

Endothelin-1 (ET-1) is a potent vasoconstrictive peptide and its activity is mediated by the receptors ET type A (EDNRA) and ET type B (EDNRB). Although ET-1 is thought to play an important role in the development of atherosclerosis, it remains unclear whether polymorphisms of ET-1 family genes, including the ET-1 gene (EDN1), EDNRA, EDNRB and the genes for endothelin converting enzymes 1 and 2 (ECE1 and ECE2), are associated with the progression of atherosclerosis. We investigated the relationship between 11 single nucleotide polymorphisms (SNPs) of ET-1 family genes (including three in EDN1, one in EDNRA, two in EDNRB, four in ECE1 and one in ECE2) and atherosclerotic changes assessed using pulse wave velocity (PWV) and carotid ultrasonography in 630 patients with essential hypertension (EHT). In male subjects, we found significant differences in brachial-ankle PWV (baPWV) in additive and recessive models in EDNRB-rs5351 after Bonferroni correction. Also in male subjects, there were significant differences in mean intima-media thickness (IMT) in additive and recessive models in EDNRA-rs5333 after Bonferroni correction. We found no significant correlation between any SNPs in the ET family genes and baPWV, IMT and Plaque score (PS) in female subjects. Furthermore, after multiple logistic regression analysis, only EDNRB-rs5351 indicated as an independent risk of atherosclerosis in male hypertensive subjects. Of the endothelin-related genes, EDNRB-rs5351 was the most susceptible SNP associated with atherosclerosis in male hypertensives, and the genetic background may be involved in the progression of atherosclerosis in EHT patients.

Authors+Show Affiliations

Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17525706

Citation

Yasuda, H, et al. "Association of Single Nucleotide Polymorphisms in Endothelin Family Genes With the Progression of Atherosclerosis in Patients With Essential Hypertension." Journal of Human Hypertension, vol. 21, no. 11, 2007, pp. 883-92.
Yasuda H, Kamide K, Takiuchi S, et al. Association of single nucleotide polymorphisms in endothelin family genes with the progression of atherosclerosis in patients with essential hypertension. J Hum Hypertens. 2007;21(11):883-92.
Yasuda, H., Kamide, K., Takiuchi, S., Matayoshi, T., Hanada, H., Kada, A., Yang, J., Miwa, Y., Yoshii, M., Horio, T., Yoshihara, F., Nakamura, S., Nakahama, H., Tei, C., Miyata, T., & Kawano, Y. (2007). Association of single nucleotide polymorphisms in endothelin family genes with the progression of atherosclerosis in patients with essential hypertension. Journal of Human Hypertension, 21(11), 883-92.
Yasuda H, et al. Association of Single Nucleotide Polymorphisms in Endothelin Family Genes With the Progression of Atherosclerosis in Patients With Essential Hypertension. J Hum Hypertens. 2007;21(11):883-92. PubMed PMID: 17525706.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of single nucleotide polymorphisms in endothelin family genes with the progression of atherosclerosis in patients with essential hypertension. AU - Yasuda,H, AU - Kamide,K, AU - Takiuchi,S, AU - Matayoshi,T, AU - Hanada,H, AU - Kada,A, AU - Yang,J, AU - Miwa,Y, AU - Yoshii,M, AU - Horio,T, AU - Yoshihara,F, AU - Nakamura,S, AU - Nakahama,H, AU - Tei,C, AU - Miyata,T, AU - Kawano,Y, Y1 - 2007/05/24/ PY - 2007/5/26/pubmed PY - 2008/1/11/medline PY - 2007/5/26/entrez SP - 883 EP - 92 JF - Journal of human hypertension JO - J Hum Hypertens VL - 21 IS - 11 N2 - Endothelin-1 (ET-1) is a potent vasoconstrictive peptide and its activity is mediated by the receptors ET type A (EDNRA) and ET type B (EDNRB). Although ET-1 is thought to play an important role in the development of atherosclerosis, it remains unclear whether polymorphisms of ET-1 family genes, including the ET-1 gene (EDN1), EDNRA, EDNRB and the genes for endothelin converting enzymes 1 and 2 (ECE1 and ECE2), are associated with the progression of atherosclerosis. We investigated the relationship between 11 single nucleotide polymorphisms (SNPs) of ET-1 family genes (including three in EDN1, one in EDNRA, two in EDNRB, four in ECE1 and one in ECE2) and atherosclerotic changes assessed using pulse wave velocity (PWV) and carotid ultrasonography in 630 patients with essential hypertension (EHT). In male subjects, we found significant differences in brachial-ankle PWV (baPWV) in additive and recessive models in EDNRB-rs5351 after Bonferroni correction. Also in male subjects, there were significant differences in mean intima-media thickness (IMT) in additive and recessive models in EDNRA-rs5333 after Bonferroni correction. We found no significant correlation between any SNPs in the ET family genes and baPWV, IMT and Plaque score (PS) in female subjects. Furthermore, after multiple logistic regression analysis, only EDNRB-rs5351 indicated as an independent risk of atherosclerosis in male hypertensive subjects. Of the endothelin-related genes, EDNRB-rs5351 was the most susceptible SNP associated with atherosclerosis in male hypertensives, and the genetic background may be involved in the progression of atherosclerosis in EHT patients. SN - 0950-9240 UR - https://www.unboundmedicine.com/medline/citation/17525706/Association_of_single_nucleotide_polymorphisms_in_endothelin_family_genes_with_the_progression_of_atherosclerosis_in_patients_with_essential_hypertension_ L2 - https://doi.org/10.1038/sj.jhh.1002234 DB - PRIME DP - Unbound Medicine ER -