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Use of combination vaccines is associated with improved coverage rates.
Pediatr Infect Dis J. 2007 Jun; 26(6):496-500.PI

Abstract

BACKGROUND

The number of shots represented by the routine childhood immunization schedule poses a logistical challenge for providers and a potential deterrent for parents. By reducing the number of injections, use of combination vaccines could lead to fewer deferred doses and improved coverage rates.

OBJECTIVE

To determine the effect of combination vaccines on coverage rates.

METHODS

This was a retrospective study of administrative claims data from the Georgia Department of Community Health Medicaid program conducted from January through September of 2003. Coverage rates were compared between children who received at least 1 dose of HepB/Hib (COMVAX) or DTaP/HepB/IPV (PEDIARIX) (the combination cohort) and children who received no doses of either combination (the reference cohort). Infants with fewer than 4 vaccination visits were excluded from the analysis. Multivariate logistic regression was performed on the whole study population to assess the effect of combination vaccines while controlling for potential confounders. Hepatitis B and pneumococcal conjugate vaccine coverage rates were not included as outcomes.

RESULTS

The study population consisted of 18,821 infants, 16,007 in the combination cohort and 2814 in the reference cohort. Unadjusted coverage rates for DTaP, IPV and the 4 DTaP:3 IPV:1 MMR, 4 DTaP: 3 IPV: 1 MMR: 3 Hib: 1 varicella, and 3 DTaP:3 IPV: 3 Hib series were higher in the combination cohort. Receipt of at least 1 dose of a combination vaccine was independently associated with increased coverage for each of these vaccines and vaccine series when controlling for gender, birth quarter, race, rural versus urban residence and historical provider immunization quality.

CONCLUSIONS

Use of combination vaccines in this Medicaid population was associated with improved coverage rates. Additional studies are warranted, including those examining private sector populations and outcomes such as timeliness and cost.

Authors+Show Affiliations

Division of Pediatric Infectious Diseases, University of Louisville School of Medicine, Louisville, KY 40202, USA. gsmars01@louisville.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17529866

Citation

Marshall, Gary S., et al. "Use of Combination Vaccines Is Associated With Improved Coverage Rates." The Pediatric Infectious Disease Journal, vol. 26, no. 6, 2007, pp. 496-500.
Marshall GS, Happe LE, Lunacsek OE, et al. Use of combination vaccines is associated with improved coverage rates. Pediatr Infect Dis J. 2007;26(6):496-500.
Marshall, G. S., Happe, L. E., Lunacsek, O. E., Szymanski, M. D., Woods, C. R., Zahn, M., & Russell, A. (2007). Use of combination vaccines is associated with improved coverage rates. The Pediatric Infectious Disease Journal, 26(6), 496-500.
Marshall GS, et al. Use of Combination Vaccines Is Associated With Improved Coverage Rates. Pediatr Infect Dis J. 2007;26(6):496-500. PubMed PMID: 17529866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of combination vaccines is associated with improved coverage rates. AU - Marshall,Gary S, AU - Happe,Laura E, AU - Lunacsek,Orsolya E, AU - Szymanski,Michael D, AU - Woods,Charles R, AU - Zahn,Matthew, AU - Russell,Argartha, PY - 2007/5/29/pubmed PY - 2007/7/27/medline PY - 2007/5/29/entrez SP - 496 EP - 500 JF - The Pediatric infectious disease journal JO - Pediatr Infect Dis J VL - 26 IS - 6 N2 - BACKGROUND: The number of shots represented by the routine childhood immunization schedule poses a logistical challenge for providers and a potential deterrent for parents. By reducing the number of injections, use of combination vaccines could lead to fewer deferred doses and improved coverage rates. OBJECTIVE: To determine the effect of combination vaccines on coverage rates. METHODS: This was a retrospective study of administrative claims data from the Georgia Department of Community Health Medicaid program conducted from January through September of 2003. Coverage rates were compared between children who received at least 1 dose of HepB/Hib (COMVAX) or DTaP/HepB/IPV (PEDIARIX) (the combination cohort) and children who received no doses of either combination (the reference cohort). Infants with fewer than 4 vaccination visits were excluded from the analysis. Multivariate logistic regression was performed on the whole study population to assess the effect of combination vaccines while controlling for potential confounders. Hepatitis B and pneumococcal conjugate vaccine coverage rates were not included as outcomes. RESULTS: The study population consisted of 18,821 infants, 16,007 in the combination cohort and 2814 in the reference cohort. Unadjusted coverage rates for DTaP, IPV and the 4 DTaP:3 IPV:1 MMR, 4 DTaP: 3 IPV: 1 MMR: 3 Hib: 1 varicella, and 3 DTaP:3 IPV: 3 Hib series were higher in the combination cohort. Receipt of at least 1 dose of a combination vaccine was independently associated with increased coverage for each of these vaccines and vaccine series when controlling for gender, birth quarter, race, rural versus urban residence and historical provider immunization quality. CONCLUSIONS: Use of combination vaccines in this Medicaid population was associated with improved coverage rates. Additional studies are warranted, including those examining private sector populations and outcomes such as timeliness and cost. SN - 0891-3668 UR - https://www.unboundmedicine.com/medline/citation/17529866/Use_of_combination_vaccines_is_associated_with_improved_coverage_rates_ L2 - https://doi.org/10.1097/INF.0b013e31805d7f17 DB - PRIME DP - Unbound Medicine ER -