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Prolonged supine hypertension due to midodrine use in an orthostatic hypotensive child.
Pediatr Cardiol. 2007 Jul-Aug; 28(4):309-10.PC

Abstract

Midodrine hydrochloride is a potent peripherally-acting alpha1 agonist that is well absorbed and rapidly metabolized to its active metabolite. It has been used for the treatment of refractory syncope but has the important side effect of supine hypertension. A 10-year-old boy with severe symptomatic orthostatic hypotension was treated with midodrine. After therapy, syncope attacks ceased but he suffered nighttime headaches, nausea, transient rash and itchy/prickly scalp. Midodrine was discontinued when supine hypertension was noticed. However, his supine hypertension continued until day 19 after discontinuation. This case shows that patients receiving midodrine should be observed for supine hypertension for a prolonged period.

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Authors+Show Affiliations

Olgar S
Department of Pediatric Cardiology, Istanbul University, Istanbul Faculty of Medicine, 34390, Capa, Istanbul, Turkey. erefolgar@yahoo.com
Omeroglu RE
No affiliation info available

MeSH

Adrenergic alpha-AgonistsChildHumansHypertensionHypotension, OrthostaticMaleMidodrineTime Factors

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

17530320

Citation

Olgar, S, and R E. Omeroglu. "Prolonged Supine Hypertension Due to Midodrine Use in an Orthostatic Hypotensive Child." Pediatric Cardiology, vol. 28, no. 4, 2007, pp. 309-10.
Olgar S, Omeroglu RE. Prolonged supine hypertension due to midodrine use in an orthostatic hypotensive child. Pediatr Cardiol. 2007;28(4):309-10.
Olgar, S., & Omeroglu, R. E. (2007). Prolonged supine hypertension due to midodrine use in an orthostatic hypotensive child. Pediatric Cardiology, 28(4), 309-10.
Olgar S, Omeroglu RE. Prolonged Supine Hypertension Due to Midodrine Use in an Orthostatic Hypotensive Child. Pediatr Cardiol. 2007 Jul-Aug;28(4):309-10. PubMed PMID: 17530320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prolonged supine hypertension due to midodrine use in an orthostatic hypotensive child. AU - Olgar,S, AU - Omeroglu,R E, Y1 - 2007/05/25/ PY - 2006/12/26/received PY - 2007/03/06/accepted PY - 2007/5/29/pubmed PY - 2007/10/10/medline PY - 2007/5/29/entrez SP - 309 EP - 10 JF - Pediatric cardiology JO - Pediatr Cardiol VL - 28 IS - 4 N2 - Midodrine hydrochloride is a potent peripherally-acting alpha1 agonist that is well absorbed and rapidly metabolized to its active metabolite. It has been used for the treatment of refractory syncope but has the important side effect of supine hypertension. A 10-year-old boy with severe symptomatic orthostatic hypotension was treated with midodrine. After therapy, syncope attacks ceased but he suffered nighttime headaches, nausea, transient rash and itchy/prickly scalp. Midodrine was discontinued when supine hypertension was noticed. However, his supine hypertension continued until day 19 after discontinuation. This case shows that patients receiving midodrine should be observed for supine hypertension for a prolonged period. SN - 0172-0643 UR - https://www.unboundmedicine.com/medline/citation/17530320/Prolonged_supine_hypertension_due_to_midodrine_use_in_an_orthostatic_hypotensive_child_ L2 - https://dx.doi.org/10.1007/s00246-006-0169-y DB - PRIME DP - Unbound Medicine ER -