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Coffee consumption and risk of incident gout in men: a prospective study.

Abstract

OBJECTIVE

Coffee is one of the most widely consumed beverages in the world and may affect the risk of gout via various mechanisms. We prospectively evaluated the relationship between coffee intake and the risk of incident gout in a large cohort of men.

METHODS

Over a 12-year period, we studied 45,869 men with no history of gout at baseline. Intake of coffee, decaffeinated coffee, tea, and total caffeine was assessed every 4 years through validated questionnaires. We used a supplementary questionnaire to ascertain whether participants met the American College of Rheumatology survey criteria for gout.

RESULTS

We documented 757 confirmed incident cases of gout. Increasing coffee intake was inversely associated with the risk of gout. The multivariate relative risks (RRs) for incident gout according to coffee consumption categories (0, <1, 1-3, 4-5, and > or = 6 cups per day) were 1.00, 0.97, 0.92, 0.60 (95% confidence interval [95% CI] 0.41-0.87), and 0.41 (95% CI 0.19-0.88), respectively (P for trend = 0.009). For decaffeinated coffee, the multivariate RRs according to consumption categories (0, <1, 1-3, and > or = 4 cups per day) were 1.00, 0.83, 0.67 (95% CI 0.54-0.82), and 0.73 (95% CI 0.46-1.17), respectively (P for trend = 0.002). Total caffeine from all sources and tea intake were not associated with the risk of gout.

CONCLUSION

These prospective data suggest that long-term coffee consumption is associated with a lower risk of incident gout.

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  • Authors+Show Affiliations

    ,

    Arthritis Research Centre of Canada, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada. hchoi@partners.org

    ,

    Source

    Arthritis and rheumatism 56:6 2007 Jun pg 2049-55

    MeSH

    Adult
    Aged
    Caffeine
    Coffee
    Cohort Studies
    Drinking Behavior
    Gout
    Health Surveys
    Humans
    Male
    Middle Aged
    Multivariate Analysis
    Prospective Studies
    Risk Factors
    Tea

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17530645

    Citation

    Choi, Hyon K., et al. "Coffee Consumption and Risk of Incident Gout in Men: a Prospective Study." Arthritis and Rheumatism, vol. 56, no. 6, 2007, pp. 2049-55.
    Choi HK, Willett W, Curhan G. Coffee consumption and risk of incident gout in men: a prospective study. Arthritis Rheum. 2007;56(6):2049-55.
    Choi, H. K., Willett, W., & Curhan, G. (2007). Coffee consumption and risk of incident gout in men: a prospective study. Arthritis and Rheumatism, 56(6), pp. 2049-55.
    Choi HK, Willett W, Curhan G. Coffee Consumption and Risk of Incident Gout in Men: a Prospective Study. Arthritis Rheum. 2007;56(6):2049-55. PubMed PMID: 17530645.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Coffee consumption and risk of incident gout in men: a prospective study. AU - Choi,Hyon K, AU - Willett,Walter, AU - Curhan,Gary, PY - 2007/5/29/pubmed PY - 2007/7/21/medline PY - 2007/5/29/entrez SP - 2049 EP - 55 JF - Arthritis and rheumatism JO - Arthritis Rheum. VL - 56 IS - 6 N2 - OBJECTIVE: Coffee is one of the most widely consumed beverages in the world and may affect the risk of gout via various mechanisms. We prospectively evaluated the relationship between coffee intake and the risk of incident gout in a large cohort of men. METHODS: Over a 12-year period, we studied 45,869 men with no history of gout at baseline. Intake of coffee, decaffeinated coffee, tea, and total caffeine was assessed every 4 years through validated questionnaires. We used a supplementary questionnaire to ascertain whether participants met the American College of Rheumatology survey criteria for gout. RESULTS: We documented 757 confirmed incident cases of gout. Increasing coffee intake was inversely associated with the risk of gout. The multivariate relative risks (RRs) for incident gout according to coffee consumption categories (0, <1, 1-3, 4-5, and > or = 6 cups per day) were 1.00, 0.97, 0.92, 0.60 (95% confidence interval [95% CI] 0.41-0.87), and 0.41 (95% CI 0.19-0.88), respectively (P for trend = 0.009). For decaffeinated coffee, the multivariate RRs according to consumption categories (0, <1, 1-3, and > or = 4 cups per day) were 1.00, 0.83, 0.67 (95% CI 0.54-0.82), and 0.73 (95% CI 0.46-1.17), respectively (P for trend = 0.002). Total caffeine from all sources and tea intake were not associated with the risk of gout. CONCLUSION: These prospective data suggest that long-term coffee consumption is associated with a lower risk of incident gout. SN - 0004-3591 UR - https://www.unboundmedicine.com/medline/citation/17530645/Coffee_consumption_and_risk_of_incident_gout_in_men:_a_prospective_study_ L2 - https://doi.org/10.1002/art.22712 DB - PRIME DP - Unbound Medicine ER -