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Motor effects of delta 9 THC in cerebellar Lurcher mutant mice.
Behav Brain Res 2007; 181(2):248-53BB

Abstract

The present study evaluated the effects of the principal active component of marijuana (delta 9 THC) on motor abilities and motor learning in mice with cerebellar dysfunction. For this purpose, spontaneous locomotor activity, equilibrium abilities, muscular tone, motor coordination and motor learning were investigated in Lurcher mutant and non-mutant B6/CBA mice 20 min after i.p. administration of 4 or 8 mg kg(-1) of delta 9 tetra hydro cannabinol (delta 9 THC). The performances were compared to those obtained by Lurcher and non-mutant mice injected with vehicle (Tween 80). The results showed that at the dose of 4 mg kg(-1) but not at the dose of 8 mg kg(-1), the cannabinoid (CB) substance reduced deficits in motor coordination, equilibrium and muscular tone and facilitated motor learning in Lurcher mice. On the other hand, only a muscular strength decrease was observed in control B6/CBA mice injected with the dose of 8 mg kg(-1) of delta 9 THC. These results suggested that cannabinoid derivative could represent a new field of investigation concerning the treatment of cerebellar ataxic syndrome in humans.

Authors+Show Affiliations

UPRES PSY.CO EA 1780, Laboratoire de Neurobiologie de l'Apprentissage, Université de Rouen, Faculté des Sciences, 76821 Mont Saint Aignan Cedex, France.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17531329

Citation

Lorivel, T, and P Hilber. "Motor Effects of Delta 9 THC in Cerebellar Lurcher Mutant Mice." Behavioural Brain Research, vol. 181, no. 2, 2007, pp. 248-53.
Lorivel T, Hilber P. Motor effects of delta 9 THC in cerebellar Lurcher mutant mice. Behav Brain Res. 2007;181(2):248-53.
Lorivel, T., & Hilber, P. (2007). Motor effects of delta 9 THC in cerebellar Lurcher mutant mice. Behavioural Brain Research, 181(2), pp. 248-53.
Lorivel T, Hilber P. Motor Effects of Delta 9 THC in Cerebellar Lurcher Mutant Mice. Behav Brain Res. 2007 Aug 6;181(2):248-53. PubMed PMID: 17531329.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Motor effects of delta 9 THC in cerebellar Lurcher mutant mice. AU - Lorivel,T, AU - Hilber,P, Y1 - 2007/04/24/ PY - 2007/01/09/received PY - 2007/04/13/revised PY - 2007/04/19/accepted PY - 2007/5/29/pubmed PY - 2007/8/19/medline PY - 2007/5/29/entrez SP - 248 EP - 53 JF - Behavioural brain research JO - Behav. Brain Res. VL - 181 IS - 2 N2 - The present study evaluated the effects of the principal active component of marijuana (delta 9 THC) on motor abilities and motor learning in mice with cerebellar dysfunction. For this purpose, spontaneous locomotor activity, equilibrium abilities, muscular tone, motor coordination and motor learning were investigated in Lurcher mutant and non-mutant B6/CBA mice 20 min after i.p. administration of 4 or 8 mg kg(-1) of delta 9 tetra hydro cannabinol (delta 9 THC). The performances were compared to those obtained by Lurcher and non-mutant mice injected with vehicle (Tween 80). The results showed that at the dose of 4 mg kg(-1) but not at the dose of 8 mg kg(-1), the cannabinoid (CB) substance reduced deficits in motor coordination, equilibrium and muscular tone and facilitated motor learning in Lurcher mice. On the other hand, only a muscular strength decrease was observed in control B6/CBA mice injected with the dose of 8 mg kg(-1) of delta 9 THC. These results suggested that cannabinoid derivative could represent a new field of investigation concerning the treatment of cerebellar ataxic syndrome in humans. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/17531329/abstract/Motor_effects_of_delta_9_THC_in_cerebellar_Lurcher_mutant_mice L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(07)00208-2 DB - PRIME DP - Unbound Medicine ER -