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Social avoidance and long-term risk for cardiovascular disease death in healthy men: the Western Electric study.
Ann Epidemiol. 2007 Aug; 17(8):591-6.AE

Abstract

PURPOSE

Although personality traits may contribute to risk for cardiovascular disease (CVD), inconsistent findings have prompted efforts to refine their measurement to include only the hostile and aggressive components. Data are sparse on the "social avoidance" (SA) subscale that measures more indirectly negative traits such as shyness. Thus, we sought to examine the association between SA and CVD, coronary heart disease (CHD), and non-CVD death.

METHODS

A total of 2107 men (ages 40-55 years) free of baseline CVD were enrolled in 1957 in the Western Electric Study. SA was measured at study entry using the four-item subscale of the Cook-Medley hostility scale to divide the cohort into four groups according to the degree of social avoidance. CHD mortality, CVD mortality, and non-CVD mortality were determined by death certificate.

RESULTS

After 30 years of follow-up, SA was associated with CVD mortality for the highest vs. the lowest SA group in age-adjusted models (hazard ratio 1.39; 95% confidence interval [95% CI] 1.04-1.84) and after adjustment for traditional CVD risk factors (hazard ratio 1.49; 95% CI 1.12-2.00). After further adjustment for measures of hostility, the findings were similar. Findings for CHD mortality were similar. However, there was no significant association between SA and non-CVD mortality.

CONCLUSIONS

Social avoidance is associated with CVD mortality but not with non-CVD mortality in middle-aged men. These findings suggest the hypothesis that social avoidance might promote CVD through physiologic, non-behavioral mechanisms.

Authors+Show Affiliations

Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. j-berry4@northwestern.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

17531506

Citation

Berry, Jarett D., et al. "Social Avoidance and Long-term Risk for Cardiovascular Disease Death in Healthy Men: the Western Electric Study." Annals of Epidemiology, vol. 17, no. 8, 2007, pp. 591-6.
Berry JD, Lloyd-Jones DM, Garside DB, et al. Social avoidance and long-term risk for cardiovascular disease death in healthy men: the Western Electric study. Ann Epidemiol. 2007;17(8):591-6.
Berry, J. D., Lloyd-Jones, D. M., Garside, D. B., Wang, R., & Greenland, P. (2007). Social avoidance and long-term risk for cardiovascular disease death in healthy men: the Western Electric study. Annals of Epidemiology, 17(8), 591-6.
Berry JD, et al. Social Avoidance and Long-term Risk for Cardiovascular Disease Death in Healthy Men: the Western Electric Study. Ann Epidemiol. 2007;17(8):591-6. PubMed PMID: 17531506.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Social avoidance and long-term risk for cardiovascular disease death in healthy men: the Western Electric study. AU - Berry,Jarett D, AU - Lloyd-Jones,Donald M, AU - Garside,Daniel B, AU - Wang,Renwei, AU - Greenland,Philip, Y1 - 2007/05/25/ PY - 2006/10/17/received PY - 2007/02/15/revised PY - 2007/03/09/accepted PY - 2007/5/29/pubmed PY - 2007/11/7/medline PY - 2007/5/29/entrez SP - 591 EP - 6 JF - Annals of epidemiology JO - Ann Epidemiol VL - 17 IS - 8 N2 - PURPOSE: Although personality traits may contribute to risk for cardiovascular disease (CVD), inconsistent findings have prompted efforts to refine their measurement to include only the hostile and aggressive components. Data are sparse on the "social avoidance" (SA) subscale that measures more indirectly negative traits such as shyness. Thus, we sought to examine the association between SA and CVD, coronary heart disease (CHD), and non-CVD death. METHODS: A total of 2107 men (ages 40-55 years) free of baseline CVD were enrolled in 1957 in the Western Electric Study. SA was measured at study entry using the four-item subscale of the Cook-Medley hostility scale to divide the cohort into four groups according to the degree of social avoidance. CHD mortality, CVD mortality, and non-CVD mortality were determined by death certificate. RESULTS: After 30 years of follow-up, SA was associated with CVD mortality for the highest vs. the lowest SA group in age-adjusted models (hazard ratio 1.39; 95% confidence interval [95% CI] 1.04-1.84) and after adjustment for traditional CVD risk factors (hazard ratio 1.49; 95% CI 1.12-2.00). After further adjustment for measures of hostility, the findings were similar. Findings for CHD mortality were similar. However, there was no significant association between SA and non-CVD mortality. CONCLUSIONS: Social avoidance is associated with CVD mortality but not with non-CVD mortality in middle-aged men. These findings suggest the hypothesis that social avoidance might promote CVD through physiologic, non-behavioral mechanisms. SN - 1047-2797 UR - https://www.unboundmedicine.com/medline/citation/17531506/Social_avoidance_and_long_term_risk_for_cardiovascular_disease_death_in_healthy_men:_the_Western_Electric_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1047-2797(07)00144-5 DB - PRIME DP - Unbound Medicine ER -