Tags

Type your tag names separated by a space and hit enter

Relationship of periodic leg movements and severity of restless legs syndrome: a study in unmedicated and medicated patients.
Clin Neurophysiol 2007; 118(7):1532-7CN

Abstract

OBJECTIVE

To evaluate the relationship of the severity of restless legs syndrome (RLS) as assessed by a subjective, patient-rated scale (International RLS Study Group Rating Scale, IRLS), and of periodic leg movements in sleep (PLMS) as an objective parameter, in two different patient populations.

METHODS

Data of 200 unmedicated patients with idiopathic RLS were evaluated. Group 1 (n=100) consisted of selected patients participating in the Pergolide European Australian RLS (PEARLS) study. Group 2 (n=100) represented an outpatient RLS population investigated in a Sleep Disorders Center. Additionally, Group 1 was also evaluated after a 6 week double-blind treatment period, where 47 patients received pergolide and 53 patients placebo.

RESULTS

In unmedicated patients, IRLS scores correlated with the PLMS-arousal index (r=0.22, p=0.033) but not with the PLMS index in Group 1 while no correlation was found in Group 2. The change of the IRLS score under treatment in Group 1 correlated significantly both with the change of the PLMS index (r=0.42, p<0.001) and the change of the PLMS-arousal index (r=0.38, p<0.001).

CONCLUSIONS

The IRLS adequately reflects treatment changes of PLMS indices. In unmedicated patients, the IRLS correlates with PLMS indices probably only in selected RLS populations with predefined PSG criteria and high PLM activity.

SIGNIFICANCE

The IRLS is an appropriate subjective rating scale for measuring treatment effects in RLS.

Authors+Show Affiliations

Department of Psychiatry and Psychotherapy, University Medical Center, Freiburg, Germany. magdolna_hornyak@psyallg.ukl.uni-freiburg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17531532

Citation

Hornyak, Magdolna, et al. "Relationship of Periodic Leg Movements and Severity of Restless Legs Syndrome: a Study in Unmedicated and Medicated Patients." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 118, no. 7, 2007, pp. 1532-7.
Hornyak M, Hundemer HP, Quail D, et al. Relationship of periodic leg movements and severity of restless legs syndrome: a study in unmedicated and medicated patients. Clin Neurophysiol. 2007;118(7):1532-7.
Hornyak, M., Hundemer, H. P., Quail, D., Riemann, D., Voderholzer, U., & Trenkwalder, C. (2007). Relationship of periodic leg movements and severity of restless legs syndrome: a study in unmedicated and medicated patients. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 118(7), pp. 1532-7.
Hornyak M, et al. Relationship of Periodic Leg Movements and Severity of Restless Legs Syndrome: a Study in Unmedicated and Medicated Patients. Clin Neurophysiol. 2007;118(7):1532-7. PubMed PMID: 17531532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of periodic leg movements and severity of restless legs syndrome: a study in unmedicated and medicated patients. AU - Hornyak,Magdolna, AU - Hundemer,Hans-Peter, AU - Quail,Deborah, AU - Riemann,Dieter, AU - Voderholzer,Ulrich, AU - Trenkwalder,Claudia, Y1 - 2007/05/24/ PY - 2006/11/21/received PY - 2007/03/22/revised PY - 2007/04/01/accepted PY - 2007/5/29/pubmed PY - 2007/7/26/medline PY - 2007/5/29/entrez SP - 1532 EP - 7 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 118 IS - 7 N2 - OBJECTIVE: To evaluate the relationship of the severity of restless legs syndrome (RLS) as assessed by a subjective, patient-rated scale (International RLS Study Group Rating Scale, IRLS), and of periodic leg movements in sleep (PLMS) as an objective parameter, in two different patient populations. METHODS: Data of 200 unmedicated patients with idiopathic RLS were evaluated. Group 1 (n=100) consisted of selected patients participating in the Pergolide European Australian RLS (PEARLS) study. Group 2 (n=100) represented an outpatient RLS population investigated in a Sleep Disorders Center. Additionally, Group 1 was also evaluated after a 6 week double-blind treatment period, where 47 patients received pergolide and 53 patients placebo. RESULTS: In unmedicated patients, IRLS scores correlated with the PLMS-arousal index (r=0.22, p=0.033) but not with the PLMS index in Group 1 while no correlation was found in Group 2. The change of the IRLS score under treatment in Group 1 correlated significantly both with the change of the PLMS index (r=0.42, p<0.001) and the change of the PLMS-arousal index (r=0.38, p<0.001). CONCLUSIONS: The IRLS adequately reflects treatment changes of PLMS indices. In unmedicated patients, the IRLS correlates with PLMS indices probably only in selected RLS populations with predefined PSG criteria and high PLM activity. SIGNIFICANCE: The IRLS is an appropriate subjective rating scale for measuring treatment effects in RLS. SN - 1388-2457 UR - https://www.unboundmedicine.com/medline/citation/17531532/Relationship_of_periodic_leg_movements_and_severity_of_restless_legs_syndrome:_a_study_in_unmedicated_and_medicated_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(07)00156-3 DB - PRIME DP - Unbound Medicine ER -