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Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study).
Am J Cardiol 2007; 99(11):1598-602AJ

Abstract

Inflammatory markers, particularly C-reactive protein (CRP), predict incident cardiovascular disease and are associated with the presence of subclinical atherosclerosis. The relations between multiple inflammatory markers and direct measures of atherosclerosis are less well established. Participants in the Offspring Cohort of the Framingham Heart Study (n = 2,885, 53% women, mean age 59 years) received routine assessments of common carotid artery intima-media thickness (CCA-IMT), internal carotid artery intima-media thickness (ICA-IMT), and the presence or absence of > or =25% carotid stenosis by ultrasonography. Circulating inflammatory markers assessed from an examination 4 years later included CRP, interleukin-6 (IL-6), intercellular adhesion molecule-1, monocyte chemoattractant protein-1, P-selectin, and CD40 ligand. Assessed as a group, inflammatory markers were significantly associated with ICA-IMT (p = 0.01), marginally with carotid stenosis (p = 0.08), but not with CCA-IMT. Individually, with an increase from the 25th to 75th percentile in IL-6, there were significant increases in ICA-IMT and carotid stenosis (for ICA-IMT, estimated fold increase 1.04, 95% confidence interval 1.03 to 1.06, p = 0.0004; for carotid stenosis, odds ratio 1.25, 95% confidence interval 1.06 to 1.47, p = 0.007) after adjustment for age, gender, and established risk factors for atherosclerosis. There was a similar significant multivariate-adjusted association of CRP with ICA-IMT but not with carotid stenosis. Smoking appeared to modify the associations of ICA-IMT with CRP (p = 0.009) and with IL-6 (p = 0.006); the association was more pronounced in current (vs former or never) smokers. In conclusion, there were modest associations of inflammatory markers, particularly IL-6, with carotid atherosclerosis. This association appears more pronounced in current smokers than in former smokers and nonsmokers.

Authors+Show Affiliations

National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17531588

Citation

Thakore, Avni H., et al. "Association of Multiple Inflammatory Markers With Carotid Intimal Medial Thickness and Stenosis (from the Framingham Heart Study)." The American Journal of Cardiology, vol. 99, no. 11, 2007, pp. 1598-602.
Thakore AH, Guo CY, Larson MG, et al. Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study). Am J Cardiol. 2007;99(11):1598-602.
Thakore, A. H., Guo, C. Y., Larson, M. G., Corey, D., Wang, T. J., Vasan, R. S., ... O'Donnell, C. J. (2007). Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study). The American Journal of Cardiology, 99(11), pp. 1598-602.
Thakore AH, et al. Association of Multiple Inflammatory Markers With Carotid Intimal Medial Thickness and Stenosis (from the Framingham Heart Study). Am J Cardiol. 2007 Jun 1;99(11):1598-602. PubMed PMID: 17531588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study). AU - Thakore,Avni H, AU - Guo,Chao-Yu, AU - Larson,Martin G, AU - Corey,Diane, AU - Wang,Thomas J, AU - Vasan,Ramachandran S, AU - D'Agostino,Ralph B,Sr AU - Lipinska,Izabella, AU - Keaney,John F,Jr AU - Benjamin,Emelia J, AU - O'Donnell,Christopher J, Y1 - 2007/04/18/ PY - 2006/09/13/received PY - 2007/01/10/revised PY - 2007/01/10/accepted PY - 2007/5/29/pubmed PY - 2007/8/3/medline PY - 2007/5/29/entrez SP - 1598 EP - 602 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 99 IS - 11 N2 - Inflammatory markers, particularly C-reactive protein (CRP), predict incident cardiovascular disease and are associated with the presence of subclinical atherosclerosis. The relations between multiple inflammatory markers and direct measures of atherosclerosis are less well established. Participants in the Offspring Cohort of the Framingham Heart Study (n = 2,885, 53% women, mean age 59 years) received routine assessments of common carotid artery intima-media thickness (CCA-IMT), internal carotid artery intima-media thickness (ICA-IMT), and the presence or absence of > or =25% carotid stenosis by ultrasonography. Circulating inflammatory markers assessed from an examination 4 years later included CRP, interleukin-6 (IL-6), intercellular adhesion molecule-1, monocyte chemoattractant protein-1, P-selectin, and CD40 ligand. Assessed as a group, inflammatory markers were significantly associated with ICA-IMT (p = 0.01), marginally with carotid stenosis (p = 0.08), but not with CCA-IMT. Individually, with an increase from the 25th to 75th percentile in IL-6, there were significant increases in ICA-IMT and carotid stenosis (for ICA-IMT, estimated fold increase 1.04, 95% confidence interval 1.03 to 1.06, p = 0.0004; for carotid stenosis, odds ratio 1.25, 95% confidence interval 1.06 to 1.47, p = 0.007) after adjustment for age, gender, and established risk factors for atherosclerosis. There was a similar significant multivariate-adjusted association of CRP with ICA-IMT but not with carotid stenosis. Smoking appeared to modify the associations of ICA-IMT with CRP (p = 0.009) and with IL-6 (p = 0.006); the association was more pronounced in current (vs former or never) smokers. In conclusion, there were modest associations of inflammatory markers, particularly IL-6, with carotid atherosclerosis. This association appears more pronounced in current smokers than in former smokers and nonsmokers. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/17531588/Association_of_multiple_inflammatory_markers_with_carotid_intimal_medial_thickness_and_stenosis__from_the_Framingham_Heart_Study__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(07)00429-8 DB - PRIME DP - Unbound Medicine ER -