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Sympathetic and renin-angiotensin systems contribute to increased blood pressure in sucrose-fed rats.
Am J Hypertens. 2007 Jun; 20(6):692-8.AJ

Abstract

BACKGROUND

This study evaluated the effect of chronic sucrose feeding on hemodynamic parameters and renal sympathetic nervous activity. In addition, angiotensin I, II, and 1-7 levels were determined in plasma, heart, kidney, and the epididymal adipose tissue.

METHODS

Male Wistar rats were treated for 30 days with 20% sucrose solution (n = 21) or tap water (n = 19) and food ad libitum. Blood pressure, cardiac output, and total peripheral resistance were recorded at the end of the 30-day treatment period. Sympathetic and angiotensinergic systems were evaluated by acute hexamethonium and captopril administration; plasma and tissue (heart, kidney, and epididymal adipose tissue) angiotensins were measured by high-performance liquid chromatography; and angiotensin-converting enzyme activity was determined by continuous fluorescent assay. Plasma renin activity and plasma levels of insulin and leptin were evaluated by radioimmunoassay.

RESULTS

Chronic sucrose feeding was associated with increased blood pressure (BP) (129 +/- 1 v 102 +/- 3 mm Hg) and circulating insulin (171%) and leptin (356%) levels when compared with the control group. The sucrose group also showed a 27% higher renal sympathetic nervous activity. The depressor response to hexamethonium was similar in both groups, whereas captopril caused a more pronounced decrease in BP in the sucrose group than in controls (-40 +/- 2 v -11 +/- 2 mm Hg), possibly reflecting the higher plasma renin activity and plasma content of angiotensin II and renal angiotensin II in sucrose rats.

CONCLUSIONS

These findings suggest a specific renal renin-angiotensin-sympathetic activation as a potential mechanism for the cardiovascular changes in response to chronic sucrose feeding.

Authors+Show Affiliations

Department of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17531930

Citation

Freitas, Raphael R de A., et al. "Sympathetic and Renin-angiotensin Systems Contribute to Increased Blood Pressure in Sucrose-fed Rats." American Journal of Hypertension, vol. 20, no. 6, 2007, pp. 692-8.
Freitas RR, Lopes KL, Carillo BA, et al. Sympathetic and renin-angiotensin systems contribute to increased blood pressure in sucrose-fed rats. Am J Hypertens. 2007;20(6):692-8.
Freitas, R. R., Lopes, K. L., Carillo, B. A., Bergamaschi, C. T., Carmona, A. K., Casarini, D. E., Furukawa, L., Heimann, J. C., Campos, R. R., & Dolnikoff, M. S. (2007). Sympathetic and renin-angiotensin systems contribute to increased blood pressure in sucrose-fed rats. American Journal of Hypertension, 20(6), 692-8.
Freitas RR, et al. Sympathetic and Renin-angiotensin Systems Contribute to Increased Blood Pressure in Sucrose-fed Rats. Am J Hypertens. 2007;20(6):692-8. PubMed PMID: 17531930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sympathetic and renin-angiotensin systems contribute to increased blood pressure in sucrose-fed rats. AU - Freitas,Raphael R de A, AU - Lopes,Karen L, AU - Carillo,Bruno A, AU - Bergamaschi,Cassia T, AU - Carmona,Adriana K, AU - Casarini,Dulce E, AU - Furukawa,Luzia, AU - Heimann,Joel C, AU - Campos,Ruy R, AU - Dolnikoff,Miriam S, PY - 2006/10/09/received PY - 2006/11/29/revised PY - 2007/01/16/accepted PY - 2007/5/29/pubmed PY - 2007/7/27/medline PY - 2007/5/29/entrez SP - 692 EP - 8 JF - American journal of hypertension JO - Am. J. Hypertens. VL - 20 IS - 6 N2 - BACKGROUND: This study evaluated the effect of chronic sucrose feeding on hemodynamic parameters and renal sympathetic nervous activity. In addition, angiotensin I, II, and 1-7 levels were determined in plasma, heart, kidney, and the epididymal adipose tissue. METHODS: Male Wistar rats were treated for 30 days with 20% sucrose solution (n = 21) or tap water (n = 19) and food ad libitum. Blood pressure, cardiac output, and total peripheral resistance were recorded at the end of the 30-day treatment period. Sympathetic and angiotensinergic systems were evaluated by acute hexamethonium and captopril administration; plasma and tissue (heart, kidney, and epididymal adipose tissue) angiotensins were measured by high-performance liquid chromatography; and angiotensin-converting enzyme activity was determined by continuous fluorescent assay. Plasma renin activity and plasma levels of insulin and leptin were evaluated by radioimmunoassay. RESULTS: Chronic sucrose feeding was associated with increased blood pressure (BP) (129 +/- 1 v 102 +/- 3 mm Hg) and circulating insulin (171%) and leptin (356%) levels when compared with the control group. The sucrose group also showed a 27% higher renal sympathetic nervous activity. The depressor response to hexamethonium was similar in both groups, whereas captopril caused a more pronounced decrease in BP in the sucrose group than in controls (-40 +/- 2 v -11 +/- 2 mm Hg), possibly reflecting the higher plasma renin activity and plasma content of angiotensin II and renal angiotensin II in sucrose rats. CONCLUSIONS: These findings suggest a specific renal renin-angiotensin-sympathetic activation as a potential mechanism for the cardiovascular changes in response to chronic sucrose feeding. SN - 0895-7061 UR - https://www.unboundmedicine.com/medline/citation/17531930/Sympathetic_and_renin_angiotensin_systems_contribute_to_increased_blood_pressure_in_sucrose_fed_rats_ L2 - https://academic.oup.com/ajh/article-lookup/doi/10.1016/j.amjhyper.2007.01.014 DB - PRIME DP - Unbound Medicine ER -