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Identification of differentially expressed proteins in striatum of maneb-and paraquat-induced Parkinson's disease phenotype in mouse.
Neurotoxicol Teratol. 2007 Sep-Oct; 29(5):578-85.NT

Abstract

Behavioral, phenotypic and biochemical changes induced by maneb+paraquat (MB+PQ) in experimental animals have shown their role in the etiologies of Parkinson's disease (PD); however, MB+PQ induced neuronal damage at genome and proteome level have not yet been clearly understood. The present study was undertaken to investigate the differential protein expression patterns in control and MB+PQ treated mouse striatum and to identify differentially expressed proteins. Animals were treated with and without MB+PQ, twice a week for three, six and nine weeks and proteome profiles of striatum were compared. Three differentially expressed proteins were identified as complexin-I, alpha-enolase and glia maturation factor-beta (GMF-beta) using 2D-PAGE and mass spectrometry. The differential expressions were also confirmed at transcription level by semi-quantitative RT-PCR. The results suggest the involvement of complexin-I, alpha-enolase and GMF-beta in MB+PQ induced PD phenotype in mouse.

Authors+Show Affiliations

Industrial Toxicology Research Centre (ITRC), Mahatma Gandhi Marg, Post Box-80, Lucknow-226 001, UP, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17532186

Citation

Patel, Suman, et al. "Identification of Differentially Expressed Proteins in Striatum of Maneb-and Paraquat-induced Parkinson's Disease Phenotype in Mouse." Neurotoxicology and Teratology, vol. 29, no. 5, 2007, pp. 578-85.
Patel S, Sinha A, Singh MP. Identification of differentially expressed proteins in striatum of maneb-and paraquat-induced Parkinson's disease phenotype in mouse. Neurotoxicol Teratol. 2007;29(5):578-85.
Patel, S., Sinha, A., & Singh, M. P. (2007). Identification of differentially expressed proteins in striatum of maneb-and paraquat-induced Parkinson's disease phenotype in mouse. Neurotoxicology and Teratology, 29(5), 578-85.
Patel S, Sinha A, Singh MP. Identification of Differentially Expressed Proteins in Striatum of Maneb-and Paraquat-induced Parkinson's Disease Phenotype in Mouse. Neurotoxicol Teratol. 2007 Sep-Oct;29(5):578-85. PubMed PMID: 17532186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of differentially expressed proteins in striatum of maneb-and paraquat-induced Parkinson's disease phenotype in mouse. AU - Patel,Suman, AU - Sinha,Ashima, AU - Singh,Mahendra Pratap, Y1 - 2007/04/27/ PY - 2007/01/22/received PY - 2007/04/11/revised PY - 2007/04/19/accepted PY - 2007/5/29/pubmed PY - 2008/1/3/medline PY - 2007/5/29/entrez SP - 578 EP - 85 JF - Neurotoxicology and teratology JO - Neurotoxicol Teratol VL - 29 IS - 5 N2 - Behavioral, phenotypic and biochemical changes induced by maneb+paraquat (MB+PQ) in experimental animals have shown their role in the etiologies of Parkinson's disease (PD); however, MB+PQ induced neuronal damage at genome and proteome level have not yet been clearly understood. The present study was undertaken to investigate the differential protein expression patterns in control and MB+PQ treated mouse striatum and to identify differentially expressed proteins. Animals were treated with and without MB+PQ, twice a week for three, six and nine weeks and proteome profiles of striatum were compared. Three differentially expressed proteins were identified as complexin-I, alpha-enolase and glia maturation factor-beta (GMF-beta) using 2D-PAGE and mass spectrometry. The differential expressions were also confirmed at transcription level by semi-quantitative RT-PCR. The results suggest the involvement of complexin-I, alpha-enolase and GMF-beta in MB+PQ induced PD phenotype in mouse. SN - 0892-0362 UR - https://www.unboundmedicine.com/medline/citation/17532186/Identification_of_differentially_expressed_proteins_in_striatum_of_maneb_and_paraquat_induced_Parkinson's_disease_phenotype_in_mouse_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0892-0362(07)00270-X DB - PRIME DP - Unbound Medicine ER -