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Prenatal evaluation of facial clefts by three-dimensional extended imaging.
Prenat Diagn. 2007 Aug; 27(8):722-9.PD

Abstract

OBJECTIVES

To determine the prenatal diagnostic accuracy of two-dimensional ultrasound (2DUS) alone versus 2DUS in conjunction with three-dimensional ultrasonography (3DUS) including orthogonal display (OGD) and three-dimensional extended Imaging for cleft lip and primary palate.

MATERIALS AND METHOD

Fetuses being suspected of having a facial cleft by previous ultrasound examination or family history were examined sequentially with 2DUS and then 3DUS.

RESULTS

Of a total of 30 infants, 22 had cleft lip and nine also had cleft palate at birth. The use of 2DUS with or without 3DUS correctly identified all cases of cleft lips prenatally. However, the use of 2DUS in conjunction with 3DUS correctly identified more cleft primary palate than 2DUS alone (88.9% vs 22.2%, P < 0.01). Cleft primary palate was well demonstrated in both the multi-slice view (MSV) and OGD modes. In one case, a cleft palate was shown in the MSV mode but not in the Oblique view (OBV) mode. All the unaffected fetuses were reported as no cleft palate with the use of MSV mode.

CONCLUSIONS

Combined approach of 2DUS and 3DUS with both OGD and MSV modes significantly improved the prenatal detection rate for a cleft palate compared with 2DUS alone (88.9% vs 22.2%) without decreasing the specificity.

Authors+Show Affiliations

Guangdong Women and Children Hospital, Ultrasound, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17533633

Citation

Wang, L M., et al. "Prenatal Evaluation of Facial Clefts By Three-dimensional Extended Imaging." Prenatal Diagnosis, vol. 27, no. 8, 2007, pp. 722-9.
Wang LM, Leung KY, Tang M. Prenatal evaluation of facial clefts by three-dimensional extended imaging. Prenat Diagn. 2007;27(8):722-9.
Wang, L. M., Leung, K. Y., & Tang, M. (2007). Prenatal evaluation of facial clefts by three-dimensional extended imaging. Prenatal Diagnosis, 27(8), 722-9.
Wang LM, Leung KY, Tang M. Prenatal Evaluation of Facial Clefts By Three-dimensional Extended Imaging. Prenat Diagn. 2007;27(8):722-9. PubMed PMID: 17533633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal evaluation of facial clefts by three-dimensional extended imaging. AU - Wang,L M, AU - Leung,K Y, AU - Tang,Mary, PY - 2007/5/30/pubmed PY - 2007/11/6/medline PY - 2007/5/30/entrez SP - 722 EP - 9 JF - Prenatal diagnosis JO - Prenat Diagn VL - 27 IS - 8 N2 - OBJECTIVES: To determine the prenatal diagnostic accuracy of two-dimensional ultrasound (2DUS) alone versus 2DUS in conjunction with three-dimensional ultrasonography (3DUS) including orthogonal display (OGD) and three-dimensional extended Imaging for cleft lip and primary palate. MATERIALS AND METHOD: Fetuses being suspected of having a facial cleft by previous ultrasound examination or family history were examined sequentially with 2DUS and then 3DUS. RESULTS: Of a total of 30 infants, 22 had cleft lip and nine also had cleft palate at birth. The use of 2DUS with or without 3DUS correctly identified all cases of cleft lips prenatally. However, the use of 2DUS in conjunction with 3DUS correctly identified more cleft primary palate than 2DUS alone (88.9% vs 22.2%, P < 0.01). Cleft primary palate was well demonstrated in both the multi-slice view (MSV) and OGD modes. In one case, a cleft palate was shown in the MSV mode but not in the Oblique view (OBV) mode. All the unaffected fetuses were reported as no cleft palate with the use of MSV mode. CONCLUSIONS: Combined approach of 2DUS and 3DUS with both OGD and MSV modes significantly improved the prenatal detection rate for a cleft palate compared with 2DUS alone (88.9% vs 22.2%) without decreasing the specificity. SN - 0197-3851 UR - https://www.unboundmedicine.com/medline/citation/17533633/Prenatal_evaluation_of_facial_clefts_by_three_dimensional_extended_imaging_ L2 - https://doi.org/10.1002/pd.1766 DB - PRIME DP - Unbound Medicine ER -