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The bioavailability of raspberry anthocyanins and ellagitannins in rats.
Mol Nutr Food Res. 2007 Jun; 51(6):714-25.MN

Abstract

The fate of anthocyanins and ellagitannins in rats was monitored following ingestion of raspberry juice. After 1 h low nM concentrations of unmetabolised anthocyanins were present in plasma but these declined by 2 h and after 4 h they were no longer detectable. For the first 2 h there was an almost full recovery of anthocyanins as they passed from the stomach through the duodenum/jejunum and into the ileum. After 3 h less than 50% were recovered, and the levels declined rapidly thereafter. Excretion of raspberry anthocyanins in urine over a 24 h period was equivalent to 1.2% of the amount ingested. Trace quantities of anthocyanins were detected in the caecum, colon and faeces and they were absent in extracts of liver, kidneys and brain. Urine also contained a number of phenolic acids but most were present in quantities well in excess of the 918 nmol of anthocyanins present in the ingested juice. These findings indicate that raspberry anthocyanins per se are poorly absorbed, probably prior to reaching the ileum, and that substantial amounts pass from the small to the large intestine where they are degraded by colonic bacteria. Ellagitannins disappeared in the stomach without accumulation of ellagic acid.

Authors+Show Affiliations

Institute of Biomedical and Life Science, University of Glasgow, Glasgow, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17533654

Citation

Borges, Gina, et al. "The Bioavailability of Raspberry Anthocyanins and Ellagitannins in Rats." Molecular Nutrition & Food Research, vol. 51, no. 6, 2007, pp. 714-25.
Borges G, Roowi S, Rouanet JM, et al. The bioavailability of raspberry anthocyanins and ellagitannins in rats. Mol Nutr Food Res. 2007;51(6):714-25.
Borges, G., Roowi, S., Rouanet, J. M., Duthie, G. G., Lean, M. E., & Crozier, A. (2007). The bioavailability of raspberry anthocyanins and ellagitannins in rats. Molecular Nutrition & Food Research, 51(6), 714-25.
Borges G, et al. The Bioavailability of Raspberry Anthocyanins and Ellagitannins in Rats. Mol Nutr Food Res. 2007;51(6):714-25. PubMed PMID: 17533654.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The bioavailability of raspberry anthocyanins and ellagitannins in rats. AU - Borges,Gina, AU - Roowi,Suri, AU - Rouanet,Jean-Max, AU - Duthie,Garry G, AU - Lean,Michael E J, AU - Crozier,Alan, PY - 2007/5/30/pubmed PY - 2007/8/19/medline PY - 2007/5/30/entrez SP - 714 EP - 25 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 51 IS - 6 N2 - The fate of anthocyanins and ellagitannins in rats was monitored following ingestion of raspberry juice. After 1 h low nM concentrations of unmetabolised anthocyanins were present in plasma but these declined by 2 h and after 4 h they were no longer detectable. For the first 2 h there was an almost full recovery of anthocyanins as they passed from the stomach through the duodenum/jejunum and into the ileum. After 3 h less than 50% were recovered, and the levels declined rapidly thereafter. Excretion of raspberry anthocyanins in urine over a 24 h period was equivalent to 1.2% of the amount ingested. Trace quantities of anthocyanins were detected in the caecum, colon and faeces and they were absent in extracts of liver, kidneys and brain. Urine also contained a number of phenolic acids but most were present in quantities well in excess of the 918 nmol of anthocyanins present in the ingested juice. These findings indicate that raspberry anthocyanins per se are poorly absorbed, probably prior to reaching the ileum, and that substantial amounts pass from the small to the large intestine where they are degraded by colonic bacteria. Ellagitannins disappeared in the stomach without accumulation of ellagic acid. SN - 1613-4125 UR - https://www.unboundmedicine.com/medline/citation/17533654/The_bioavailability_of_raspberry_anthocyanins_and_ellagitannins_in_rats_ L2 - https://doi.org/10.1002/mnfr.200700024 DB - PRIME DP - Unbound Medicine ER -