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Respiratory virus infection in infants and children.
Pediatr Dev Pathol. 2007 May-Jun; 10(3):172-80.PD

Abstract

The recent availability of diagnostic polymerase chain reaction-based assays for the detection of viral pathogens has allowed us to identify the infectious agents present in a large percentage of culture-negative specimens. The information gained by these studies has led to a reassessment of the prevalence of individual viruses in lower respiratory tract infections in both normal and immunocompromised children. Pathologic examination of less severe cases identified by more sensitive methodologies in immunocompetent children is now possible and has prompted the realization that many of the classic features of particular viral infections in the lung are in fact hallmarks of fulminant disease. In this article we review the body of literature discussing these anatomic findings, the approaches taken by those investigators, and the types of reagents that are commercially available.

Authors+Show Affiliations

Department of Pathology and Laboratory Medicine, Columbus Children's Hospital, Columbus, OH, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17535096

Citation

Hammond, Sue, et al. "Respiratory Virus Infection in Infants and Children." Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, vol. 10, no. 3, 2007, pp. 172-80.
Hammond S, Chenever E, Durbin JE. Respiratory virus infection in infants and children. Pediatr Dev Pathol. 2007;10(3):172-80.
Hammond, S., Chenever, E., & Durbin, J. E. (2007). Respiratory virus infection in infants and children. Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 10(3), 172-80.
Hammond S, Chenever E, Durbin JE. Respiratory Virus Infection in Infants and Children. Pediatr Dev Pathol. 2007 May-Jun;10(3):172-80. PubMed PMID: 17535096.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Respiratory virus infection in infants and children. AU - Hammond,Sue, AU - Chenever,Emily, AU - Durbin,Joan E, PY - 2007/03/29/received PY - 2007/04/03/accepted PY - 2007/5/31/pubmed PY - 2007/7/26/medline PY - 2007/5/31/entrez SP - 172 EP - 80 JF - Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society JO - Pediatr Dev Pathol VL - 10 IS - 3 N2 - The recent availability of diagnostic polymerase chain reaction-based assays for the detection of viral pathogens has allowed us to identify the infectious agents present in a large percentage of culture-negative specimens. The information gained by these studies has led to a reassessment of the prevalence of individual viruses in lower respiratory tract infections in both normal and immunocompromised children. Pathologic examination of less severe cases identified by more sensitive methodologies in immunocompetent children is now possible and has prompted the realization that many of the classic features of particular viral infections in the lung are in fact hallmarks of fulminant disease. In this article we review the body of literature discussing these anatomic findings, the approaches taken by those investigators, and the types of reagents that are commercially available. SN - 1093-5266 UR - https://www.unboundmedicine.com/medline/citation/17535096/Respiratory_virus_infection_in_infants_and_children_ DB - PRIME DP - Unbound Medicine ER -