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Decreased basal levels of glucagon-like peptide-1 after weight loss in obese subjects.
Ann Nutr Metab. 2007; 51(2):134-8.AN

Abstract

OBJECTIVE

Basal glucagon-like peptide-1 (GLP-1) concentrations seem to be attenuated in obese subjects, although statistical significance is unclear. Only a few studies have investigated the effect of weight reduction on GLP-1 concentrations and have found unclear results. The aim of the present study was to determine whether subjects who lose weight on a hypocaloric diet experience the same change in circulating GLP-1 levels as subjects who do not lose weight.

MATERIAL AND METHODS

A population of 99 obese nondiabetic outpatients was analyzed in a prospective way. Weight and blood pressure were determined. Basal glucose, C-reactive protein, insulin, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, and basal GLP-1 blood levels were measured before and after 3 months of hypocaloric diet. Bipolar impedance examination was performed in all patients to assess body composition. The lifestyle modification program consisted of a hypocaloric diet (1,520 kcal, 52% carbohydrates, 25% lipids and 23% proteins). The exercise program consisted of aerobic exercise for at least 3 times per week (60 min each).

RESULTS

Ninety-nine patients (20 male/79 female) gave informed consent and were enrolled in the study. Fourteen patients (2 male/12 female) did not lose weight (group I: weight increase of 2 +/- 1.1 kg, NS) and 75 patients (18 male/67 female) lost weight (group II, weight loss of 4 +/- 1.6 kg, p < 0.05). Weight, body mass index, fat mass, waist circumference, insulin, HOMA, LDL cholesterol, triglycerides and systolic blood pressure improved in group II, without significant statistical changes in group I. In group I, basal GLP-1 levels remained unchanged (7.4 +/- 3.1 vs. 7.15 +/- 3.6 ng/ml, NS). In group II, GLP-1 levels decreased significantly (8.4%, 6.88 +/- 2.5 vs. 6.3 +/- 2.4 ng/ml, p < 0.05). In the multivariate analysis with a dependent variable (levels of GLP-1 after hypocaloric diet adjusted by age and sex), only insulin levels remained as an independent predictor in the model (F = 5.9; p < 0.05), with an increase of 0.6 ng/ml (CI 95%: 0.1-1.1) in GLP-1 concentrations with each 1-mIU/ml increase of insulin.

CONCLUSION

Hypocaloric diet decreased GLP-1 levels in patients with weight loss with a significant improvement in anthropometric parameters and cardiovascular risk factors. Nevertheless, patients without weight loss after dietary treatment exhibited unchanged GLP-1 levels. Basal insulin correlates with basal GLP-1.

Authors+Show Affiliations

Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17536190

Citation

de Luis, D A., et al. "Decreased Basal Levels of Glucagon-like Peptide-1 After Weight Loss in Obese Subjects." Annals of Nutrition & Metabolism, vol. 51, no. 2, 2007, pp. 134-8.
de Luis DA, Gonzalez Sagrado M, Conde R, et al. Decreased basal levels of glucagon-like peptide-1 after weight loss in obese subjects. Ann Nutr Metab. 2007;51(2):134-8.
de Luis, D. A., Gonzalez Sagrado, M., Conde, R., Aller, R., & Izaola, O. (2007). Decreased basal levels of glucagon-like peptide-1 after weight loss in obese subjects. Annals of Nutrition & Metabolism, 51(2), 134-8.
de Luis DA, et al. Decreased Basal Levels of Glucagon-like Peptide-1 After Weight Loss in Obese Subjects. Ann Nutr Metab. 2007;51(2):134-8. PubMed PMID: 17536190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased basal levels of glucagon-like peptide-1 after weight loss in obese subjects. AU - de Luis,D A, AU - Gonzalez Sagrado,M, AU - Conde,R, AU - Aller,R, AU - Izaola,O, Y1 - 2007/05/29/ PY - 2006/04/24/received PY - 2006/12/27/accepted PY - 2007/5/31/pubmed PY - 2007/7/21/medline PY - 2007/5/31/entrez SP - 134 EP - 8 JF - Annals of nutrition & metabolism JO - Ann. Nutr. Metab. VL - 51 IS - 2 N2 - OBJECTIVE: Basal glucagon-like peptide-1 (GLP-1) concentrations seem to be attenuated in obese subjects, although statistical significance is unclear. Only a few studies have investigated the effect of weight reduction on GLP-1 concentrations and have found unclear results. The aim of the present study was to determine whether subjects who lose weight on a hypocaloric diet experience the same change in circulating GLP-1 levels as subjects who do not lose weight. MATERIAL AND METHODS: A population of 99 obese nondiabetic outpatients was analyzed in a prospective way. Weight and blood pressure were determined. Basal glucose, C-reactive protein, insulin, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, and basal GLP-1 blood levels were measured before and after 3 months of hypocaloric diet. Bipolar impedance examination was performed in all patients to assess body composition. The lifestyle modification program consisted of a hypocaloric diet (1,520 kcal, 52% carbohydrates, 25% lipids and 23% proteins). The exercise program consisted of aerobic exercise for at least 3 times per week (60 min each). RESULTS: Ninety-nine patients (20 male/79 female) gave informed consent and were enrolled in the study. Fourteen patients (2 male/12 female) did not lose weight (group I: weight increase of 2 +/- 1.1 kg, NS) and 75 patients (18 male/67 female) lost weight (group II, weight loss of 4 +/- 1.6 kg, p < 0.05). Weight, body mass index, fat mass, waist circumference, insulin, HOMA, LDL cholesterol, triglycerides and systolic blood pressure improved in group II, without significant statistical changes in group I. In group I, basal GLP-1 levels remained unchanged (7.4 +/- 3.1 vs. 7.15 +/- 3.6 ng/ml, NS). In group II, GLP-1 levels decreased significantly (8.4%, 6.88 +/- 2.5 vs. 6.3 +/- 2.4 ng/ml, p < 0.05). In the multivariate analysis with a dependent variable (levels of GLP-1 after hypocaloric diet adjusted by age and sex), only insulin levels remained as an independent predictor in the model (F = 5.9; p < 0.05), with an increase of 0.6 ng/ml (CI 95%: 0.1-1.1) in GLP-1 concentrations with each 1-mIU/ml increase of insulin. CONCLUSION: Hypocaloric diet decreased GLP-1 levels in patients with weight loss with a significant improvement in anthropometric parameters and cardiovascular risk factors. Nevertheless, patients without weight loss after dietary treatment exhibited unchanged GLP-1 levels. Basal insulin correlates with basal GLP-1. SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/17536190/Decreased_basal_levels_of_glucagon_like_peptide_1_after_weight_loss_in_obese_subjects_ L2 - https://www.karger.com?DOI=10.1159/000103273 DB - PRIME DP - Unbound Medicine ER -