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Self-reported dietary supplement use is confirmed by biological markers in the Norwegian Mother and Child Cohort Study (MoBa).
Ann Nutr Metab 2007; 51(2):146-54AN

Abstract

BACKGROUND/AIMS

A food frequency questionnaire (FFQ) and a database for dietary supplements were developed for use in the Norwegian Mother and Child Cohort Study (MoBa). The aim of the present study was to investigate the relation between reported use and biomarkers in supplement and non-supplement users and to validate self-reported intake of dietary supplements in mid pregnancy.

METHOD

120 women were recruited from MoBa, and 119 subjects completed the MoBa FFQ and a 4-day weighed food diary. Information on supplement use was collected by both methods. Venous blood specimens and 24-hour urine samples were obtained for measurement of dietary biomarkers.

RESULTS

Biomarker concentration/excretion and intake differed significantly between supplement and non-supplement users for vitamin D, carotenoids, folate, the n-6/n-3 fatty acid ratio and iodine (p < 0.05 for all variables). Flavonoid excretion was higher in flavonoid-supplement users (p < 0.05). Significant correlations between total dietary intake (food and supplements) and biomarker concentration/excretion were found for vitamin D (r = 0.45, p < 0.001), folate (r = 0.26, p = 0.005), the n-6/n-3 fatty acid ratio (r = 0.36, p < 0.001) and iodine (r = 0.42, p < 0.001).

CONCLUSION

The biochemical indicators examined in this study confirmed differences in self-reported micronutrient intake between supplement and non-supplement users for vitamin D, beta-carotene, folate, n-3 fatty acids, flavonoids and iodine.

Authors+Show Affiliations

Division of Environmental Medicine, Department of Food Toxicology, Norwegian Institute of Public Health, Oslo, Norway. anne.lise.brantsaeter@fhi.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17536192

Citation

Brantsaeter, Anne Lise, et al. "Self-reported Dietary Supplement Use Is Confirmed By Biological Markers in the Norwegian Mother and Child Cohort Study (MoBa)." Annals of Nutrition & Metabolism, vol. 51, no. 2, 2007, pp. 146-54.
Brantsaeter AL, Haugen M, Hagve TA, et al. Self-reported dietary supplement use is confirmed by biological markers in the Norwegian Mother and Child Cohort Study (MoBa). Ann Nutr Metab. 2007;51(2):146-54.
Brantsaeter, A. L., Haugen, M., Hagve, T. A., Aksnes, L., Rasmussen, S. E., Julshamn, K., ... Meltzer, H. M. (2007). Self-reported dietary supplement use is confirmed by biological markers in the Norwegian Mother and Child Cohort Study (MoBa). Annals of Nutrition & Metabolism, 51(2), pp. 146-54.
Brantsaeter AL, et al. Self-reported Dietary Supplement Use Is Confirmed By Biological Markers in the Norwegian Mother and Child Cohort Study (MoBa). Ann Nutr Metab. 2007;51(2):146-54. PubMed PMID: 17536192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Self-reported dietary supplement use is confirmed by biological markers in the Norwegian Mother and Child Cohort Study (MoBa). AU - Brantsaeter,Anne Lise, AU - Haugen,Margaretha, AU - Hagve,Tor-Arne, AU - Aksnes,Lage, AU - Rasmussen,Salka E, AU - Julshamn,Kåre, AU - Alexander,Jan, AU - Meltzer,Helle Margrete, Y1 - 2007/05/29/ PY - 2006/12/18/received PY - 2007/02/16/accepted PY - 2007/5/31/pubmed PY - 2007/7/21/medline PY - 2007/5/31/entrez SP - 146 EP - 54 JF - Annals of nutrition & metabolism JO - Ann. Nutr. Metab. VL - 51 IS - 2 N2 - BACKGROUND/AIMS: A food frequency questionnaire (FFQ) and a database for dietary supplements were developed for use in the Norwegian Mother and Child Cohort Study (MoBa). The aim of the present study was to investigate the relation between reported use and biomarkers in supplement and non-supplement users and to validate self-reported intake of dietary supplements in mid pregnancy. METHOD: 120 women were recruited from MoBa, and 119 subjects completed the MoBa FFQ and a 4-day weighed food diary. Information on supplement use was collected by both methods. Venous blood specimens and 24-hour urine samples were obtained for measurement of dietary biomarkers. RESULTS: Biomarker concentration/excretion and intake differed significantly between supplement and non-supplement users for vitamin D, carotenoids, folate, the n-6/n-3 fatty acid ratio and iodine (p < 0.05 for all variables). Flavonoid excretion was higher in flavonoid-supplement users (p < 0.05). Significant correlations between total dietary intake (food and supplements) and biomarker concentration/excretion were found for vitamin D (r = 0.45, p < 0.001), folate (r = 0.26, p = 0.005), the n-6/n-3 fatty acid ratio (r = 0.36, p < 0.001) and iodine (r = 0.42, p < 0.001). CONCLUSION: The biochemical indicators examined in this study confirmed differences in self-reported micronutrient intake between supplement and non-supplement users for vitamin D, beta-carotene, folate, n-3 fatty acids, flavonoids and iodine. SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/17536192/Self_reported_dietary_supplement_use_is_confirmed_by_biological_markers_in_the_Norwegian_Mother_and_Child_Cohort_Study__MoBa__ L2 - https://www.karger.com?DOI=10.1159/000103275 DB - PRIME DP - Unbound Medicine ER -