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Times to pain relief and pain freedom with rizatriptan 10 mg and other oral triptans.
Int J Clin Pract. 2007 Jul; 61(7):1091-111.IJ

Abstract

BACKGROUND

In the clinical trial setting, oral rizatriptan 10 mg has greater efficacy than other oral triptans in freedom from migraine headache pain 2 h after dosing.

OBJECTIVE

The study objective is to compare the effectiveness of rizatriptan 10 mg and other oral triptans for acute migraine attack in a naturalistic setting.

METHODS

A total of 673 patients took rizatriptan 10 mg or their usual-care oral triptans for two migraine attacks in a sequential, cross-over manner and recorded outcomes using a diary and a stopwatch. Mean and median times to pain relief (PR) and pain freedom (PF) for rizatriptan and other oral triptans were compared. The effect of rizatriptan on times to PR and PF, adjusting for potential confounding factors (treatment sequence, treatment order and use of rescue medication), was computed via a Cox proportional hazard model.

RESULTS

Significantly, more patients taking rizatriptan achieved both PR and PF within 2 h after dosing than other oral triptans. Times to PR and PF were shorter with rizatriptan than with other oral triptans (median time to PR: 45 vs. 52 min, p < 0.0001; median time to PF: 100 vs. 124 min, p < 0.0001). The adjusted proportional hazard ratios (rizatriptan vs. other oral triptans) for times to PR and PF were 1.32 (95% CI: 1.22-1.44) and 1.27 (95% CI: 1.16-1.39) respectively.

CONCLUSION

The times to PR and PF in a 'naturalistic' setting were significantly shorter for patients treating a migraine attack with rizatriptan 10 mg than with other oral triptans.

Authors+Show Affiliations

Outcomes Research and Management, Merck & Co., Inc., West Point, PA 19486, USA. daisy_ng_mak@merck.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17537184

Citation

Ng-Mak, D S., et al. "Times to Pain Relief and Pain Freedom With Rizatriptan 10 Mg and Other Oral Triptans." International Journal of Clinical Practice, vol. 61, no. 7, 2007, pp. 1091-111.
Ng-Mak DS, Hu XH, Chen Y, et al. Times to pain relief and pain freedom with rizatriptan 10 mg and other oral triptans. Int J Clin Pract. 2007;61(7):1091-111.
Ng-Mak, D. S., Hu, X. H., Chen, Y., Ma, L., & Solomon, G. (2007). Times to pain relief and pain freedom with rizatriptan 10 mg and other oral triptans. International Journal of Clinical Practice, 61(7), 1091-111.
Ng-Mak DS, et al. Times to Pain Relief and Pain Freedom With Rizatriptan 10 Mg and Other Oral Triptans. Int J Clin Pract. 2007;61(7):1091-111. PubMed PMID: 17537184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Times to pain relief and pain freedom with rizatriptan 10 mg and other oral triptans. AU - Ng-Mak,D S, AU - Hu,X H, AU - Chen,Y, AU - Ma,L, AU - Solomon,G, Y1 - 2007/05/30/ PY - 2007/6/1/pubmed PY - 2007/12/19/medline PY - 2007/6/1/entrez SP - 1091 EP - 111 JF - International journal of clinical practice JO - Int J Clin Pract VL - 61 IS - 7 N2 - BACKGROUND: In the clinical trial setting, oral rizatriptan 10 mg has greater efficacy than other oral triptans in freedom from migraine headache pain 2 h after dosing. OBJECTIVE: The study objective is to compare the effectiveness of rizatriptan 10 mg and other oral triptans for acute migraine attack in a naturalistic setting. METHODS: A total of 673 patients took rizatriptan 10 mg or their usual-care oral triptans for two migraine attacks in a sequential, cross-over manner and recorded outcomes using a diary and a stopwatch. Mean and median times to pain relief (PR) and pain freedom (PF) for rizatriptan and other oral triptans were compared. The effect of rizatriptan on times to PR and PF, adjusting for potential confounding factors (treatment sequence, treatment order and use of rescue medication), was computed via a Cox proportional hazard model. RESULTS: Significantly, more patients taking rizatriptan achieved both PR and PF within 2 h after dosing than other oral triptans. Times to PR and PF were shorter with rizatriptan than with other oral triptans (median time to PR: 45 vs. 52 min, p < 0.0001; median time to PF: 100 vs. 124 min, p < 0.0001). The adjusted proportional hazard ratios (rizatriptan vs. other oral triptans) for times to PR and PF were 1.32 (95% CI: 1.22-1.44) and 1.27 (95% CI: 1.16-1.39) respectively. CONCLUSION: The times to PR and PF in a 'naturalistic' setting were significantly shorter for patients treating a migraine attack with rizatriptan 10 mg than with other oral triptans. SN - 1368-5031 UR - https://www.unboundmedicine.com/medline/citation/17537184/Times_to_pain_relief_and_pain_freedom_with_rizatriptan_10_mg_and_other_oral_triptans_ DB - PRIME DP - Unbound Medicine ER -