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Beneficial effect of succinic acid monoethyl ester on erythrocyte membrane bound enzymes and antioxidant status in streptozotocin-nicotinamide induced type 2 diabetes.
Chem Biol Interact. 2007 Aug 15; 169(1):15-24.CB

Abstract

Succinic acid monoethyl ester (EMS) was recently proposed as an insulinotropic agent for the treatment of non-insulin dependent diabetes mellitus. In the present study the effect of EMS and metformin on erythrocyte membrane bound enzymes and antioxidants activity in plasma and erythrocytes of streptozotocin-nicotinamide induced type 2 diabeteic model was investigated. Succinic acid monoethyl ester was administered intraperitonially for 30 days to control and diabetic rats. The effect of EMS on glucose, insulin, hemoglobin, glycosylated hemoglobin, TBARS, hydroperoxide, superoxide dismutase (SOD), catalase (CAT), glutathione peroxide (Gpx), glutathione-S-transferase (GST), vitamins C and E, reduced glutathione (GSH) and membrane bound enzymes were studied. The effect of EMS was compared with metformin, a reference drug. The levels of glucose, glycosylated hemoglobin, TBARS, hyderoperoxide, and vitamin E were increased significantly whereas the level of insulin and hemoglobin, as well as antioxidants (SOD, CAT, Gpx, GST, vitamin C and GSH) membrane bound total ATPase, Na(+)/K(+)-ATPase, Ca(2+)-ATPase and Mg(2+)-ATPase were decreased significantly in streptozotocin-nicotinamide diabetic rats. Administration of EMS to diabetic rats showed a decrease in the levels of glucose, glycosylated hemoglobin, lipid peroxidation markers and vitamin E. In addition the levels of insulin, hemoglobin, enzymic antioxidants, vitamin C, and GSH and the activities of membrane bound enzymes also were increased in EMS and metformin treated diabetic rats. The present study indicates that the EMS possesses a significant beneficial effect on erythrocyte membrane bound enzymes and antioxidants defense system in addition to its antidiabetic effect.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu 608002, India. paribalaji@gmail.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17537413

Citation

Pari, L, and R Saravanan. "Beneficial Effect of Succinic Acid Monoethyl Ester On Erythrocyte Membrane Bound Enzymes and Antioxidant Status in Streptozotocin-nicotinamide Induced Type 2 Diabetes." Chemico-biological Interactions, vol. 169, no. 1, 2007, pp. 15-24.
Pari L, Saravanan R. Beneficial effect of succinic acid monoethyl ester on erythrocyte membrane bound enzymes and antioxidant status in streptozotocin-nicotinamide induced type 2 diabetes. Chem Biol Interact. 2007;169(1):15-24.
Pari, L., & Saravanan, R. (2007). Beneficial effect of succinic acid monoethyl ester on erythrocyte membrane bound enzymes and antioxidant status in streptozotocin-nicotinamide induced type 2 diabetes. Chemico-biological Interactions, 169(1), 15-24.
Pari L, Saravanan R. Beneficial Effect of Succinic Acid Monoethyl Ester On Erythrocyte Membrane Bound Enzymes and Antioxidant Status in Streptozotocin-nicotinamide Induced Type 2 Diabetes. Chem Biol Interact. 2007 Aug 15;169(1):15-24. PubMed PMID: 17537413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beneficial effect of succinic acid monoethyl ester on erythrocyte membrane bound enzymes and antioxidant status in streptozotocin-nicotinamide induced type 2 diabetes. AU - Pari,L, AU - Saravanan,R, Y1 - 2007/05/04/ PY - 2007/02/13/received PY - 2007/04/19/revised PY - 2007/04/20/accepted PY - 2007/6/1/pubmed PY - 2007/9/15/medline PY - 2007/6/1/entrez SP - 15 EP - 24 JF - Chemico-biological interactions JO - Chem Biol Interact VL - 169 IS - 1 N2 - Succinic acid monoethyl ester (EMS) was recently proposed as an insulinotropic agent for the treatment of non-insulin dependent diabetes mellitus. In the present study the effect of EMS and metformin on erythrocyte membrane bound enzymes and antioxidants activity in plasma and erythrocytes of streptozotocin-nicotinamide induced type 2 diabeteic model was investigated. Succinic acid monoethyl ester was administered intraperitonially for 30 days to control and diabetic rats. The effect of EMS on glucose, insulin, hemoglobin, glycosylated hemoglobin, TBARS, hydroperoxide, superoxide dismutase (SOD), catalase (CAT), glutathione peroxide (Gpx), glutathione-S-transferase (GST), vitamins C and E, reduced glutathione (GSH) and membrane bound enzymes were studied. The effect of EMS was compared with metformin, a reference drug. The levels of glucose, glycosylated hemoglobin, TBARS, hyderoperoxide, and vitamin E were increased significantly whereas the level of insulin and hemoglobin, as well as antioxidants (SOD, CAT, Gpx, GST, vitamin C and GSH) membrane bound total ATPase, Na(+)/K(+)-ATPase, Ca(2+)-ATPase and Mg(2+)-ATPase were decreased significantly in streptozotocin-nicotinamide diabetic rats. Administration of EMS to diabetic rats showed a decrease in the levels of glucose, glycosylated hemoglobin, lipid peroxidation markers and vitamin E. In addition the levels of insulin, hemoglobin, enzymic antioxidants, vitamin C, and GSH and the activities of membrane bound enzymes also were increased in EMS and metformin treated diabetic rats. The present study indicates that the EMS possesses a significant beneficial effect on erythrocyte membrane bound enzymes and antioxidants defense system in addition to its antidiabetic effect. SN - 0009-2797 UR - https://www.unboundmedicine.com/medline/citation/17537413/Beneficial_effect_of_succinic_acid_monoethyl_ester_on_erythrocyte_membrane_bound_enzymes_and_antioxidant_status_in_streptozotocin_nicotinamide_induced_type_2_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-2797(07)00127-5 DB - PRIME DP - Unbound Medicine ER -