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Oxalate intake and the risk for nephrolithiasis.

Abstract

Most kidney stones consist of calcium oxalate, and higher urinary oxalate increases the risk for calcium oxalate nephrolithiasis. However, the relation between dietary oxalate and stone risk is unclear. This study prospectively examined the relation between oxalate intake and incident nephrolithiasis in the Health Professionals Follow-up Study (n = 45,985 men), the Nurses' Health Study I (n = 92,872 older women), and the Nurses' Health Study II (n = 101,824 younger women). Food frequency questionnaires were used to assess oxalate intake every 4 yr. Cox proportional hazards regression was used to adjust for age, body mass index, thiazide use, and dietary factors. A total of 4605 incident kidney stones were documented over a combined 44 yr of follow-up. Mean oxalate intakes were 214 mg/d in men, 185 mg/d in older women, and 183 mg/d in younger women and were similar in stone formers and non-stone formers. Spinach accounted for >40% of oxalate intake. For participants in the highest compared with lowest quintile of dietary oxalate, the relative risks for stones were 1.22 (95% confidence interval [CI] 1.03 to 1.45; P = 0.01 for trend) for men and 1.21 (95% CI 1.01 to 1.44; P = 0.05 for trend) for older women. Risk was higher in men with lower dietary calcium (P = 0.08 for interaction). The relative risks for participants who ate eight or more servings of spinach per month compared with fewer than 1 serving per month were 1.30 (95% CI 1.08 to 1.58) for men and 1.34 (95% CI 1.10 to 1.64) for older women. Oxalate intake and spinach were not associated with risk in younger women. These data do not implicate dietary oxalate as a major risk factor for nephrolithiasis.

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  • Authors+Show Affiliations

    ,

    Channing Laboratory, Third Floor, Brigham and Women's Hospital, Boston, MA 02115, USA. entaylor@partners.org

    Source

    MeSH

    Adult
    Aged
    Female
    Follow-Up Studies
    Humans
    Male
    Middle Aged
    Nephrolithiasis
    Oxalates
    Prospective Studies
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    17538185

    Citation

    Taylor, Eric N., and Gary C. Curhan. "Oxalate Intake and the Risk for Nephrolithiasis." Journal of the American Society of Nephrology : JASN, vol. 18, no. 7, 2007, pp. 2198-204.
    Taylor EN, Curhan GC. Oxalate intake and the risk for nephrolithiasis. J Am Soc Nephrol. 2007;18(7):2198-204.
    Taylor, E. N., & Curhan, G. C. (2007). Oxalate intake and the risk for nephrolithiasis. Journal of the American Society of Nephrology : JASN, 18(7), pp. 2198-204.
    Taylor EN, Curhan GC. Oxalate Intake and the Risk for Nephrolithiasis. J Am Soc Nephrol. 2007;18(7):2198-204. PubMed PMID: 17538185.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Oxalate intake and the risk for nephrolithiasis. AU - Taylor,Eric N, AU - Curhan,Gary C, Y1 - 2007/05/30/ PY - 2007/6/1/pubmed PY - 2007/10/31/medline PY - 2007/6/1/entrez SP - 2198 EP - 204 JF - Journal of the American Society of Nephrology : JASN JO - J. Am. Soc. Nephrol. VL - 18 IS - 7 N2 - Most kidney stones consist of calcium oxalate, and higher urinary oxalate increases the risk for calcium oxalate nephrolithiasis. However, the relation between dietary oxalate and stone risk is unclear. This study prospectively examined the relation between oxalate intake and incident nephrolithiasis in the Health Professionals Follow-up Study (n = 45,985 men), the Nurses' Health Study I (n = 92,872 older women), and the Nurses' Health Study II (n = 101,824 younger women). Food frequency questionnaires were used to assess oxalate intake every 4 yr. Cox proportional hazards regression was used to adjust for age, body mass index, thiazide use, and dietary factors. A total of 4605 incident kidney stones were documented over a combined 44 yr of follow-up. Mean oxalate intakes were 214 mg/d in men, 185 mg/d in older women, and 183 mg/d in younger women and were similar in stone formers and non-stone formers. Spinach accounted for >40% of oxalate intake. For participants in the highest compared with lowest quintile of dietary oxalate, the relative risks for stones were 1.22 (95% confidence interval [CI] 1.03 to 1.45; P = 0.01 for trend) for men and 1.21 (95% CI 1.01 to 1.44; P = 0.05 for trend) for older women. Risk was higher in men with lower dietary calcium (P = 0.08 for interaction). The relative risks for participants who ate eight or more servings of spinach per month compared with fewer than 1 serving per month were 1.30 (95% CI 1.08 to 1.58) for men and 1.34 (95% CI 1.10 to 1.64) for older women. Oxalate intake and spinach were not associated with risk in younger women. These data do not implicate dietary oxalate as a major risk factor for nephrolithiasis. SN - 1046-6673 UR - https://www.unboundmedicine.com/medline/citation/17538185/Oxalate_intake_and_the_risk_for_nephrolithiasis_ L2 - http://jasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=17538185 DB - PRIME DP - Unbound Medicine ER -