Tags

Type your tag names separated by a space and hit enter

Dose-response effects of different plant sterol sources in fat spreads on serum lipids and C-reactive protein and on the kinetic behavior of serum plant sterols.
Eur J Clin Nutr. 2008 Aug; 62(8):968-77.EJ

Abstract

OBJECTIVE

To test the dose-response effect on low-density lipoprotein cholesterol (LDL-c) of plant sterols (PS) from different sources in a low-fat spread.

METHODS

Dose responses of soybean oil (BO), tall oil (TO) and a mix of tall oil and rapeseed oil (TO/RP) as fatty acid esters were tested in a parallel design in free-living subjects recruited from the general community who had elevated cholesterol concentrations. Subjects received either control for 6 weeks or 1.6 g PS per day for 3 weeks, then 3.0 g/day for 3 weeks.

RESULTS

LDL-c was lowered significantly by consumption of 1.6 g/day of PS (-10.4%, range -7.3 to -11.4%). Increasing the dose to 3.0 g/day modestly reduced LDL-c concentrations further to -14.7%. TO, containing 78% sitosterol, produced an increase in serum sitosterol of 6.5 nmol/ml, while BO, containing only 27% campesterol, produced an increase in serum campesterol of 9.5 nmol/ml in 6 weeks. After PS withdrawal, serum sterols declined by 50% within 2 weeks.

CONCLUSION

Different PS sources were equally effective in lowering serum LDL-c concentrations. The decrease in absolute concentrations of LDL-c was dependent on the baseline concentrations.

Authors+Show Affiliations

CSIRO Human Nutrition, Adelaide, South Australia, Australia. peter.clifton@csiro.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17538539

Citation

Clifton, P M., et al. "Dose-response Effects of Different Plant Sterol Sources in Fat Spreads On Serum Lipids and C-reactive Protein and On the Kinetic Behavior of Serum Plant Sterols." European Journal of Clinical Nutrition, vol. 62, no. 8, 2008, pp. 968-77.
Clifton PM, Mano M, Duchateau GS, et al. Dose-response effects of different plant sterol sources in fat spreads on serum lipids and C-reactive protein and on the kinetic behavior of serum plant sterols. Eur J Clin Nutr. 2008;62(8):968-77.
Clifton, P. M., Mano, M., Duchateau, G. S., van der Knaap, H. C., & Trautwein, E. A. (2008). Dose-response effects of different plant sterol sources in fat spreads on serum lipids and C-reactive protein and on the kinetic behavior of serum plant sterols. European Journal of Clinical Nutrition, 62(8), 968-77.
Clifton PM, et al. Dose-response Effects of Different Plant Sterol Sources in Fat Spreads On Serum Lipids and C-reactive Protein and On the Kinetic Behavior of Serum Plant Sterols. Eur J Clin Nutr. 2008;62(8):968-77. PubMed PMID: 17538539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dose-response effects of different plant sterol sources in fat spreads on serum lipids and C-reactive protein and on the kinetic behavior of serum plant sterols. AU - Clifton,P M, AU - Mano,M, AU - Duchateau,G S M J E, AU - van der Knaap,H C M, AU - Trautwein,E A, Y1 - 2007/05/30/ PY - 2007/6/1/pubmed PY - 2009/1/1/medline PY - 2007/6/1/entrez SP - 968 EP - 77 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 62 IS - 8 N2 - OBJECTIVE: To test the dose-response effect on low-density lipoprotein cholesterol (LDL-c) of plant sterols (PS) from different sources in a low-fat spread. METHODS: Dose responses of soybean oil (BO), tall oil (TO) and a mix of tall oil and rapeseed oil (TO/RP) as fatty acid esters were tested in a parallel design in free-living subjects recruited from the general community who had elevated cholesterol concentrations. Subjects received either control for 6 weeks or 1.6 g PS per day for 3 weeks, then 3.0 g/day for 3 weeks. RESULTS: LDL-c was lowered significantly by consumption of 1.6 g/day of PS (-10.4%, range -7.3 to -11.4%). Increasing the dose to 3.0 g/day modestly reduced LDL-c concentrations further to -14.7%. TO, containing 78% sitosterol, produced an increase in serum sitosterol of 6.5 nmol/ml, while BO, containing only 27% campesterol, produced an increase in serum campesterol of 9.5 nmol/ml in 6 weeks. After PS withdrawal, serum sterols declined by 50% within 2 weeks. CONCLUSION: Different PS sources were equally effective in lowering serum LDL-c concentrations. The decrease in absolute concentrations of LDL-c was dependent on the baseline concentrations. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17538539/Dose_response_effects_of_different_plant_sterol_sources_in_fat_spreads_on_serum_lipids_and_C_reactive_protein_and_on_the_kinetic_behavior_of_serum_plant_sterols_ L2 - https://doi.org/10.1038/sj.ejcn.1602814 DB - PRIME DP - Unbound Medicine ER -